He aha ka pyrroloquinoline quinone (pqq)?

ʻO ka pyrroloquinoline quinone (PQQ) i ʻike ʻia ka methoxatin he ʻano mea e like me ka cofactor e like me ka nui o ka nui o nā mea kanu. Ua hele kūlohelohe ʻo PQQ ma nā umauma umauma o ka manu a me nā ʻamaka mammalian.

Eia naʻe, loaʻa wale i nā minuke minuke ma ka meaʻai i laila pqq paupū ʻōpala pono pono ka loaʻa ʻana o ka waiwai i loko o ke kino.

ʻO ka PQQ ma mua he mea i ʻike ʻia he coenzyme i nā bacteria i like ka like me ka B-Vitamin ma nā kānaka, a ke hana nei i ka hoʻolaha ʻana i ka ulu ʻana o kēia mau mea.

I nā kāne, e hana ia me ka mea ulu ole-vitamina e pili ana i nā pono olakino he nui.

Ka hana hana

Pyrroloquinoline quinone (pqq) hōʻike i nā pono olakino he nui ma o nā hana like ʻole e like me ke hoʻoponopono ʻana i nā ala ʻōkole, a hoʻoneʻe i nā radical free a me ka hana redox.

ʻO nā hana pqq o ka hana he:

• E pili ana i ke ʻano o ka hana o nā ʻano genes

Hiki i ka quinone Pyrroloquinoline ke pili i ka ala e haʻi ʻia ai nā ʻano ʻehā a me nā mea hou i komo i ka hana mitochondria. ʻO kāna hana antioxidant e ʻōlelo ʻia he 100 mau manawa ka nui o ka vitamin C.

Ua hōʻike ʻia ka hoʻohui hoʻohui PQQ e hoʻoulu ai i ka CREB a me PGC-1a hōʻailona ala i nā ala i pili i ka pili me ka mitochondria biogenesis.

E hana i kahi antioxidant

ʻO ka hana anti-oxidative ka pyrroloquinoline (pqq) ma muli o kona hiki ke hoʻohaʻahaʻa ʻia i ka PQQH2 ma o ka hopena me ka hoʻēmi ʻana i nā mea e like me ka cysteine, kaomi a i ʻole nitrotinamide adenine dinucleotide phosphate (NADPH).

• Ke hōʻike nei i nā enzyme

Hōʻalo ka pyrroloquinoline quinone i ka hoʻoneʻe thioredoxin hōʻano liʻiliʻi 1 (TrxR1), ma ka mea, e hoʻoneʻe i ka hana Nuclear factor erythroid 2-pili pili 2 (Nrf2) mau mea e hoʻolaha nei i ka hana antioxidant.

Ua ʻike ʻia nō hoʻi ka PQQ e pale i ka hoʻomohala ʻana o ka quinoproteins (e hōʻino ana i nā protein) e alakaʻi i ka maʻi o Parkinson.

ʻO nā pono nui (PQQ) nā pono quinone pyrroloquinoline

Nui nā pono o ka pyrroloquinoline quinone me nā:

i i. Hoʻopuka ka PQQ i ka hana mitochondrial

ʻO ka Mitochondria nā organelles e hana ana i ka ikehu i loko o nā mea i loko o ke ʻano me ka ATP ma o ka hanu o ka cellular. Hoʻomaopopo pinepine ʻia lākou i nā home no nā mea hoʻonaʻauao a i ʻole o nā ʻoihana waiwai.

ʻO ka hana ʻana o ka ikehu ke kī nui i kahi olakino olakino.

Ua pili nā Mitochondrial dysfunction i kekahi mau pilikia e like me ka hoʻonui ʻana i ka ulu, nāwaliwali o ka naʻau, nā pilikia neurodegenerative e like me ka maʻi cardiac, ke kaumaha a me ka maʻi diabetes i waena o nā kūlana olakino.

Hoʻonui ka pyrroloquinoline quinone i ka hana mitochondrial ma ka hoʻouluʻana i ka hana hou ʻana o nā cell mitochondria (mitochondrial biogenesis). Hoʻopuka ʻia kēia e ka hoʻowalewale o ke kumuhana CAMP responsive e kīloi ana i ka protein 1 (CREB) a me ka Peroxisome proliferator-activated receptor-gamma coactivator (PGC) -1alpha, nā ala e hoʻōki i ka biogenesis mitochondrial.

Hoʻonui ka pyrroloquinoline quinone i nā mea transkripment e hana ana e like me nā antiioxidants i loko o ka mitochondria no laila e pale iā mākou mai ke koʻikoʻi oxidative.

Hoʻopau hou ka Pqq i nā enzymes i ka mitochondria e hoʻonui i ka hana o ka ikehu.

I kahi hiʻohiʻona pālolo, hōʻike ʻia ka hewa o PQQ i ka meaʻai i hoʻohaumia ai ka hana mitochondrial.

pōmaikaʻi quinone pyrroloquinoline

ii. Hoʻonui i ke kuniu

ʻO ka maʻi maʻi maʻi ke kumu o nā pilikia maʻamau e like me ka maʻi puʻuwai a me ka maʻi diabetes. ʻO ka quinone Pyrroloquinoline aia nā waiwai antioxidant e kōkua ai e kāpae i nā hoʻopalewale i nā mea a laila e pale aku ai i ka maʻi a me ka hōʻino.

Hōʻike kekahi mau noiʻi i kēlā Hoʻohui ʻia PQQ hopena i nā hopena kupaianaha o nā mea hōʻailona like ʻole e like me ka nitric oxide i nā lā ʻekolu wale nō.

I loko o ka noiʻi ʻana i nā pōmole e loaʻa ana i ka lāʻau rheumatoid, ua hōʻike ʻia ka PQQ e hāʻawi i ka pale i ka hōʻemi ʻana i ka maʻi ma hope o nā lā 45 mau lā.

iii. Hoʻonui i ke olakino olakino a me ka hana

Loaʻa i ka pyrroloquinoline quinone ke ulu hou i ka lolo (neurogenesis) ma o ka hana nui o nā mea ulu ulu.

Ua hoʻohālikelike kekahi noiʻi e hoʻonui i ka pqq supplementing i ka ulu ʻana o ka ulu ʻana o ka pehu (NGF) a me nā selona neuron.

Ua pili pū ʻia ka pyrroloquinoline quinone me ka hoʻomanaʻo ʻana o ka hoʻomanaʻo a me ka aʻo ʻana ma muli o kona hiki ke hoʻoponopono hou i nā puna o ka lolo.

Ma kahi noiʻi e pili ana i ka 41 kanaka olakino akā ua ʻōpiopio, ua lawelawe ʻia ʻo PQQ ma 20 mg / lā no nā wiki he 12 e pale i ka hōʻemi o ka hana o ka lolo, ʻoi aku ka nānā ʻana a me ka hoʻomanaʻo ʻana.

Hiki ke kōkua ka Pyrroloquinoline quinone i ka pale ʻana i ka hōʻeha o ka lolo.

Ma ka makahiki 2012, kahi noiʻi o nā lālani i hāʻawi ʻia i ka pqq no 3 mau lā ma mua o ka hōʻeha ʻana o ka puʻuwai traumatic i ʻike ua hiki i ke kumumanaʻo ke pale aku i nā ʻopa olakino i kēia hōʻeha.

iv. Hoʻomaikaʻi ka PQQ i ka hiamoe

ʻO ka kōkua o Pyrroloquinoline quinone (PQQ) i ka hoʻonui ʻana i kāu ʻano hiamoe ma ka hoʻokaʻawale ʻana i ka manawa i hiamoe ai, e hoʻonui ana i ka lōʻihi o ka hiamoe a hoʻomaikaʻi i ka maikaʻi o ka hiamoe.

Hiki i ka Pyrroloquinoline quinone ke emi iki i ka nui o ke kao o ka stress (cortisol) i loko o nā kānaka a no laila hoʻomaikaʻi i kā lākou hiamoe.

I loko o kahi haʻawina o nā pākeke 17, PQQ i hāʻawi ʻia ma 20 mg / lā no 8 mau wiki i loaʻa i ka hoʻomaikaʻi ʻana i ka maikaʻi o ka hiamoe ma ke ʻano o ka hoʻonui ʻana o ka hiamoe a me ka haʻahaʻa hiamoe.

Hoʻomaikaʻi ka PQQ i ka hiamoe

v. Hoʻomaikaʻi i ke olakino naʻau

ʻO ka hiki i ka quinone pyrroloquinoline e kaohi i nā pae o ka cholesterol e hoʻoemi i ka hopena o ka maʻi o ka naʻau e like me ka hōʻeha.

Ma kahi noiʻi o ka 29 mau pākeke, hoʻohui i ka pqq i hōʻemi nui i nā pae kolamu LDL kino.

ʻO ka quinone Pyrroloquinoline hoʻi e hōʻemi i nā pae triglycerides e alakaʻi i ka hana mitochondrial i hoʻonui ʻia. I kahi noiʻi ʻana me nā kiʻī, ua ʻike ʻia ka ppq e hoʻohaʻahaʻa i ko lākou pae triglyceride.

Hiki i ke kōkua Pqq ke kōkua i ka pale a hōʻole ʻana i ka atherosclerosis (stroke). Ua hōʻike kekahi mau noiʻi e hiki i ka ppq ke hoʻohaʻahaʻa i ka protein C-reactive a me ka trimethylamine-N-oxide nā mea nui nui o nā maʻi.

vi. E hiki paha i kahi mea lōʻihi lōʻihi

ʻO ka quinone ʻo Pyrroloquinoline i manaʻo ʻia he mea e ole ai i-mea momona ulu a no laila hiki ke kōkua i ka hoʻopiʻi ʻana i kou ulu a me ka ulu ʻana.

Pyrroloquinoline quinone hana i ka hakakā ʻana i ka huhū, ke pale ʻana i ke ahulau oxidative a me ke kākoʻo ʻana i ka hana mitochondrial i mea i hōʻoia ai i kona hiki ke hoʻonui i ke ola o kekahi.

Ua hōʻike ʻia nō hoʻi ʻo PQQ i ka hana kino i nā ala ʻōpiopio e hoʻohuli ai i ka kahiko cellular old.

ʻO nā hopena synergetic i lawe ʻia mai kēia mau hana hana hiki i ka PQQ ke pale aku iā ʻoe mai ka pāloe cellular a hoʻonui pū i ka lōʻihi.

Ma kahi hiʻohiʻona holoholona, ​​loaʻa i ka hoʻohui pū me ka pqq e hoʻemi i ka pohihihi oxidative me ka hoʻonui ʻana i ka nui o ke ola o nā pōpoki.

vii. Ka palekana mai ke kaumaha oxidative

Hoʻopili ʻia ka PQQ i nā protein i kēia mea e pale i ka maʻi o nā maʻi. Hiki iā ia ke loaʻa i nā radical manuahi i ke kino.

I kahi noiʻi holoholona, ​​ua loaʻa ka pqq supplementation i pale ai i ka pili o ka mate selona pili.

ʻO kekahi noiʻi ʻē aʻe i hana ma ka vitro ua hōʻike ʻo PQQ pale i nā pona mitochondria i hoʻokaʻawale ʻia mai ka pōʻino ma hope o ke kaumaha o ka oxidative stress a hoʻopau i nā radica superoxide.

Ke aʻo hou ʻana me nā kiʻomana maʻi pakania o ka scorzzococin-induced (STZ), PQQ i hāʻawi ʻia ma ka 20 mg / kg kino momona no nā lā 15 i ʻike ʻia e hōʻemi i nā pae serum o ka glucose a me ka huahana o ka lipid peroxidation, a ua hāpai hou i nā hana a antioxidants ma ka lolo ʻoi i ka maʻi diabetes. . ^ E Ha yM.

Hoʻohana nā pyrroloquinoline quinone a loaʻa nā pono i nā pono:

Kāohi i ka momona

Hoʻomaikaʻi i ka ʻōnaehana pale

Hoʻomaikaʻi i ka hoʻoulu

Hoʻolako i ka hana kognitive a me ka hoʻomanaʻo

Kōkua i ka luhi kaua

I ke kūlana i kēia manawa, i ka lono ʻino no ka COVID 19 e hōʻea i kēlā me kēia manawa. Hiki ke hoʻohana ʻia ke kaua ʻo Pyrroloquinoline quinone coronavirus. Hoʻonui kēia hōʻoluʻolu hoihoi i kou pale kino a hāʻawi pū i ke kōkua hiamoe e hoʻomaha i kou kaumaha.

Hoʻohana ʻia ka pyrroloquinoline quinone

He aha nā hopena hopena o ka pyrroloquinoline quinone (pqq)?

Ke loaʻa nei ka PQQ mai nā kumu meaʻai e manaʻo ʻole ʻole nā ​​hopena ʻē ke ʻole he maʻi ʻona i kekahi meaʻai.

I nā haʻawina holoholona me nā kiʻī, ua pili ka maʻi haki me ka supplemental PQQ. I loko o hoʻokahi haʻawina e pili ana i nā kahe, ua hopu ʻia ʻo PQQ ma 11-12 mg / kg kino kino i hōʻike ʻia i ka ʻehaʻeha o nā keiki.

Ma loko o kekahi noiʻi o nā kahe, ʻike ʻia ʻo ka PQQ ma 20 mg / kg bodyweight e hoʻoulu ai i ka maʻi o ka māla a me ka hepatic i hoʻopaʻa ʻia.

Ua hōʻike pū ʻia nā mea make i ka lālima me nā kumu kiʻekiʻe o ka 500 mg.

I nā kāne, ʻaʻole i hōʻike ʻia nā hopena pale pyrroloquinoline quinone me nā dosis a hiki i 20 mg / lā.

Eia nō naʻe, i nā hanana e loaʻa ʻole, hiki i kekahi mau hopena pyrroloquinoline quinone hiki ke ulu mai ma muli o ka lawe nui ʻana. ʻO kēia mau hopena komo ka hopena o ka hōʻeha, ka luhi, ka hiamoe, ke hypersensitivity a me ka insomnia.

ʻO ka helu o ka PQQ

No ka mea, ʻaʻole i apono nui ʻia ka pyrroloquinoline quinone (pqq) e ka Federal Drug Administration no ka hoʻohana ʻana i nā lāʻau lapaʻau, ʻaʻohe ʻano pyrroloquinoline quinone dosage e kū nei, ʻoiai ua ʻike kekahi mau noiʻi ua waiwai nā pyrroloquinoline quinone mai 2 mg / lā. Eia nō naʻe, ʻo ka hapa nui o nā waihona PQQ ma loko o nā poho o 20 a 40 mg.

Pyrroloquinoline quinone dosis ʻano loli paha i ke kumu i manaʻo ʻia. Ke hōʻike nei kekahi mau haʻawina e pono ka nui o ka nui o 0.075 a 0.3 mg / kg i ka lā i ka hoʻomaikaʻi ʻana i ka hana mitochondria, aʻo ka mea kiʻekiʻe aʻe e pili ana i 20 mg i kēlā me kēia lā e pono ai ke hakakā me ka mumū.

I ka manawa e hui pū ai me COQ10, e ʻōlelo ʻia nā kekona o 20 mg PQQ a me 200 mg COQ10, ʻoiai ʻo kekahi mau noiʻi e hoʻohana ana i 20 mg o PQQ a me 300 mg COQ10 ʻaʻole i hōʻike i kahi hopena hoʻopiʻi.

ʻO ka mea noiʻi PQQ e lawe ʻia ma ke ʻano maʻamau a ʻoi aku hoʻi ma mua o ka pāʻina-ma kahi ʻōpū ʻole.

No laila ua ʻōlelo nui ʻia ʻoe e hoʻomaka mai nā haʻahaʻa haʻahaʻa a hoʻonui i ka mea pono.

A e ʻike pono i ka nui o nā haʻawina ʻaʻole makemake e lawe i kahi maʻa ma mua o 80 mg i kēlā me kēia lā.

He aha nā meaʻai e loaʻa ai nā quinone pyrroloquinoline (pqq)?

Loaʻa ka Pyrroloquinoline quinone (pqq) i ka nui o nā mea kanu mea kanu, ʻoiai hoʻi ma ka haʻahaʻa haʻahaʻa loa. Loaʻa i nā mea kanu nā PQQ pololei mai nā lepo a me nā lepo baki e like me ka methylotrophic, rhizobium, a me nā huakini acetobacter.

Pqq i loko o nā lau o ke kanaka e hele mai i kekahi ʻāpana mai ka meaʻai a ma kekahi ʻāpana mai ka hana neʻe ʻana o enteric bacteria.

ʻO ka pae o ka quinine pyrroloquinoline i loko o kēia mau wahi meaʻai e ʻano ākea ana mai ka 0.19 a 61ng / g. Eia naʻe, ʻoi aku ka nui o nā pqq i loko o nā meaʻai i lalo iho nei:

Nā meaʻai Pqq

ʻO nā kumuwaiwai ʻē aʻe o ka PQQ nā kolu broccoli, mustard, pānaʻo fava, huaʻa, huaʻala, berena, ka waiū a me ka waiū.

Ma muli o ka haʻahaʻa o ka pqq i ka nui o nā meaʻai, paʻakikī ke loaʻa i ka nui o ka lawa e hakakā i nā pono e pili ana i ka pqq ke ʻole mākou e lawe i kahi nui loa o kahi meaʻai. Pono kēia e kūʻai i ka mea hoʻohui pqq e hoʻohui i ka meaʻai maikaʻi.

PQQ a me COQ10

ʻO ka coenzyme Q10 (COQ10) i manaʻo pinepine ʻia e ka mitochondria enhancer e hana ana i loko o ke kino kanaka a i loko hoʻi o ka nui o nā meaʻai. Ua like ia me PQQ; Eia naʻe, hana ka pyrroloquinoline quinine a me CQ10 ma nā wahi ʻē loa a hoʻohana paha i nā hana ʻokoʻa no ka hoʻomaikaʻi ʻana i nā hana mitochondrial.

He cofactor koʻikoʻi ka Qenzyme Q10 e hana ana i loko o ka mitochondria a he kumu nui loa ia i ka ʻā ʻana o ka cellular a me ka hoʻohana ʻana i ka oxygen no ka hana ʻana i ka ikehu. ʻO PQQ ma ka ʻaoʻao ʻē aʻe e hoʻonui i ka nui o nā cell mitochondria a hoʻomaikaʻi hou i ka pono mitochondria.

Ke hui pū ʻia, ʻo ka pyrroloquinoline quinine a me CQ10, e hāʻawi i nā hopena synergetic i ka hoʻomaikaʻi ʻana i ka hana mitochondrial, pale iā mākou mai ka hoʻāhuā oxidative a me ka hoʻoponopono ʻana i nā ala kelepona hōʻailona.

E kūʻai i ka hoʻohui PQQ

Nui nā pōmaikaʻi kūpono ʻole o ka pqq supplement powder a pono ʻoe e noʻonoʻo e hoʻopau i kāu meaʻai me ia. Loaʻa ka pauku PQQ no ka kūʻai aku i ka pūnaewele. Eia nō naʻe, no nā hopena maikaʻi loa e makaʻala ʻē aku inā kūʻai ʻoe i ka hoʻohui pqq e hōʻoia ai i loaʻa iā ʻoe ka maikaʻi maikaʻi loa.

Inā noʻonoʻo ʻoe i ke kūʻai ʻana i ka pauka pqq bulk e loaʻa ai ia mai nā mea lawelawe hanohano.

E hoʻomaopopo '

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  2. Harris CB1, Chowanadisai W, Mishchuk DO, Satre MA, Slupsky CM, RBK RB. ^ E Ha yM. (2013). Nā hakanui pyrroloquinoline quinone (PQQ) e hoʻololi i nā hōʻailona o ka mumū a me ka metabolism pili i ka mitochondrial e pili ana i nā kumuhana kanaka. J Nutr Biochem.Kau; 24 (12): 2076-84. Doi: 10.1016 / j.jnutbio.2013.07.008.
  3. Kumazawa T., Sato K., Seno H., Ishii A., a me Suzuki O. (1995). Nā pae o nā quinone pyrroloquinoline i nā meaʻai like ʻole. J.307: 331–333.
  4. Nunome K., Miyazaki S., Nakano M., Iguchi-Ariga S., Ariga H. (2008). Pyrroloquinoline quinone pale i ka make neuronalative stress-hoʻoneʻe i ka make neuronal make ma o nā loli i ke kūlana oxidative o DJ-1. Kaukaola. Bull. 31: 1321–1326.
  5. Paul Hwang & Darryn S. Willoughby (2018). Nā ʻakano ʻokoʻa ma hope o Pyrroloquinoline Hoʻonui ʻia ma Quinone ma ka ʻiwi o ka ʻili o Mitochondrial Biogenesis: E hiki paha i nā huaʻōlelo Synergistic me nā hoʻomaʻamaʻa, nā nīpepa o ka American College of Nutrition, 37: 8, 738-748, DOI: 1080 / 07315724.2018.1461146.
  6. Hoʻoikaika T, Nā Storm D, a me Bauerly K, et al. (2006). Palapala piha: Pyrroloquinoline quinone e hoʻololi i ka nui mitochondrial a hana i loko o nā kiʻi. J Nutr. ^ E Ha yM. Feb; 136 (2): 390-6.
  7. Zhang L, Liu J, Cheng C, Yuan Y, Yu B, Shen A, Yan M. (2012). ʻO ka hopena neuroprotective o ka quinone pyrroloquinoline ma ka hōʻeha o ka lolo traumatic. J Neurotrauma. Mar 20; 29 (5): 851-64.

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