Video
hoakaka
| Product Name | ʻO ka Nicotinamide Mononucleotide (NMN) ka pauka |
| Inoa inoa | NAMN, β-NMN, β-Nicotinamide Mononucleotide a i ʻole Beta Nicotinamide Mononucleotide; NMN;
beta-NMN |
| Kōpana Drug | Pākuʻi Dietary |
| Kāleka CAS | 1094-61-7 |
| InChIKey | DAYLJWODMCOQEW-TURQNECASA-N |
| Kaulana Molecular | C11H15N2O8P |
| Kaumaha Molecular | 334.22 g / mole |
| Monoisotopic Mass | 334.056602 g / mole |
| Lae Melting | 166 ° C (dec.) |
| Kukui ʻʻī | N / A |
| ʻO ka Halifa-Ola | N / A |
| kala like 'ole | Keʻokeʻo i keʻokeʻo keʻokeʻo keʻokeʻo |
| Palekana | Hāʻawi ʻia ʻo Beta-NMN ma ke ʻano he crystalline paʻa. Mālama liʻiliʻi ʻo Beta-NMN i nā mea hoʻoheheʻe kūlohelohe e like me ka etanol, DMSO, a me ka dimethyl formamide. No nā hoʻokolohua olaola, hōʻike mākou i nā ʻōnaehana hoʻohehehehe wai ʻole o Beta-NMN e hoʻomākaukau ʻia e ka wehe pono ʻana i ka crystalline paʻa i nā pale wai. ʻO ka solubility o Beta-NMN ma PBS, pH 7.2, ma kahi o 10 mg / ml. ʻAʻole mākou e paipai i ka mālama ʻana i ka hopena wai a ʻoi aku no hoʻokahi lā. |
| Mahana mālama | ʻO ke keʻena temperatur;
E mālama ma -20 ° C a i 2 mau makahiki. |
| noi | Pākuʻi ʻai anti-kūnewa |
Mōʻaukala o NMN
ʻO Nicotinamide mononucleotide (haʻilula mole: C11H15N2O8P, helu CAS: 1094-61-7, a kapa ʻia ʻo NMN, beta-Nicotinamide mononucleotide a i ʻole β-NMN) kahi huaola B3 metabolite [1], i loaʻa maoli i loko o ke kino o ke kanaka, a me ka maʻamau. nā meaʻai e like me broccoli a me kāpī i nā liʻiliʻi liʻiliʻi [2].
Hoʻomaka ka NMN e loaʻa ka hoihoi ma ke ʻano he mea kōkua hānai kūpono i ka 2013, ma hope o kahi noiʻi holomua i alakaʻi ʻia e nā ʻepekema Harvard ma nāʻiole [3,4].
Ua hana mua ʻia ʻo NMN ma ke ʻano he mea kōkua no nā kānaka i ka makahiki 2015 [5], akā pipiʻi loa ia i ka hana ʻana, a hiki i ka hoʻomohala ʻia ʻana o nā hana e hoʻoliʻiliʻi i nā kumukūʻai hana a hoʻonui i ka maʻemaʻe ma 2018 [6], a ma ia manawa ua hoʻomākaukau ʻia nā hale hana no ka hana nui i hoʻomaka e hele mai ma ka pūnaewele.
He aha ka pauka NMN?
ʻO Nicotinamide mononucleotide (haʻilula mole: C11H15N2O8P, helu CAS: 1094-61-7, a kapa ʻia ʻo NMN, beta-Nicotinamide mononucleotide a i ʻole β-NMN) kahi huaola B3 metabolite [1], i loaʻa maoli i loko o ke kino o ke kanaka, a me ka maʻamau. nā meaʻai e like me broccoli a me kāpī i nā liʻiliʻi liʻiliʻi [2].
ʻO Nicotinamide Mononucleotide (NMN) kahi hui kūlohelohe i kū liʻiliʻi i loko o ke kino o ke kanaka a me kekahi mau meaʻai. He bioavailable waha ʻo NMN, a ke lawe waha ʻia hiki ke kākoʻo i nā pae NAD + ma loko o ka akepaʻa a me nā mākala puʻupuʻu.
Ua hōʻike ʻia kahi noiʻi hou e hiki i ka NMN ke kākoʻo i ke olakino cardiovascular, ka hana ʻana i ka ikehu, ke olakino noʻonoʻo, a me ke olakino retinal a iwi. ʻO kahi mea hoihoi loa i ka noiʻi NMN ka mea hiki ke hāpai i ka hoʻomaikaʻi ʻana o DNA a kākoʻo i ka hoʻoulu ʻana o nā genes SIRTUIN i manaʻo ʻia he mea nui i ka ʻelemakule olakino.
Pehea e holo ai?
ʻO NMN kahi mea mua i ka mole mika NAD; koi ke kino o ke kanaka iā NMN i mea e hana ai i kāna NAD + ponoʻī.
ʻO NAD + kahi ʻano oxidised o NAD (Nicotinamide adenine dinucleotide), kahi mole i ʻike ʻia i ka makahiki 1906, a loaʻa i nā hunaola ola āpau [7].
Hoʻohui me NAD + iho ʻaʻole ia he koho e hoʻonui ai i nā pae NAD +, no ka mea nui nui ia e hiki koke keʻaʻe i nā membrane pūnaewele e komo i nā hunaola, a no laila ʻaʻole hiki ke hoʻopili maikaʻi i ka metabolism [8].
Nā pōmaikaʻi NMN.
ʻO kahi ala e hiki ai iā mākou ke kākoʻo i nā pae olakino o NAD + ma ke kākoʻo ʻana i ko mākou kino me kāna mea i hele mua, nicotinamide mononucleotide (NMN).
Hōʻike ka noiʻi o kēia manawa i kēia loli ma waena o NR a me NMN e pono ai no ke komo ʻana i kekahi mau ʻano cell. Alakaʻi kēia i nā kānaka noiʻi e manaʻoʻiʻo i ka NMN, ʻo ka ʻoiaʻiʻo, ʻo ia kekahi o nā ala wikiwiki loa e hoʻoulu ai i ka hana NAD. Eia nō naʻe, ʻo Nicotinamide mononucleotide paukū e hōʻoia nei i ko lākou pono anti-kūnewa ponoʻī ma mua o nā hana o NAD wale nō.
Ma waho o ke ala metabolic NAD, hiki ke hoʻohui pololei ʻia ka pauka NMN i nā hunaola me ka hoʻohuli ʻole ʻia i ka NAD. Ua hiki i kēia hanana ke loaʻa i nā protein halihali hou i loaʻa e hoʻonui ana i ka helu ma hope o ka hāʻule ʻana o nā pae NAD. I kēia palapala, hāʻawi ʻo NMN i ka ikehu o ka pūnaewele a ʻae i kēlā me kēia waiwai anti-kūnewa i haʻi ʻia ma mua e hoʻolauna ʻia e nā hunaola me ka hiki ke ulu a ulu hou.
Koho i hoʻoponopono hou me ka pauka NMN me NAD e hāʻawi i kahi ala pololei loa i ka hoʻolaha ʻana i ka metabolism cell a no laila ʻoi aku ka wikiwiki o ka hana like. Eia kekahi, ua ʻike ʻia ka pauka Nicotinamide mononucleotide e hoʻomaikaʻi i ka hana a me ka hana ʻana o ka insulin, e loaʻa ana i nā pono metabolic hou aʻe a me ka hoʻomanawanui glucose. ʻO ka mea nui, hiki i nā mea hoʻohui NMN ke kōkua i ka hana e hoʻohaʻahaʻa i nā kūlana metabolic e like me ka maʻi diabetes, ka maʻi momona momona, a me ka momona. [11]
Nā Pōmaikaʻi kūpono ʻē aʻe o NMN
- Paipai i ke olakino Vascular a me ke kahe o ke koko. [11]
- Hoʻonui i ka hoʻomanawanui ʻana i ka mākala a me ka ikaika
- Pale aku i ka maʻi puʻuwai
- Nā hoʻohaʻahaʻa haʻahaʻa o ka momona. [10]
- Hoʻonui i ka mālama ʻana o ka hoʻoponopono ʻana iā DNA
- Hoʻonui i ka Hana Mitochondrial. [9]
Pehea e loaʻa ai ka NMN kūpaʻa, maʻemaʻe, palekana?
I mea e hoʻoholo ai pehea e hiki ai ke hoʻokō i kahi huahana paʻa, ʻoiaʻiʻo, maʻemaʻe a palekana, ua alakaʻi ʻia kahi moʻo o nā hoʻokolohua a me nā kānana. Hiki ke hāʻawi ʻia nā hōʻike COA, HPLC a me HNMR.
Hoʻomaikaʻi i ke kūpaʻa
Ma ke kālailai ʻana i ke ʻano mononucleotide Nicotinamide a me ka hoʻohana ʻana i ka hoʻoili hoʻoilina a me ka in-situ FTIR nānā hana, ua ʻike ʻia he hoʻokahi ka paʻakai o loko o NMN a ʻo ka isoelectric point o ka paʻakai o loko ka mea nui o ka NMN instability ʻO ka wai, ma ke ʻano he mole mole, e hoʻohuli i ka hoʻoili uila ma waena o NMN e hiki ke luku i ka iwi paʻakai o loko o NMN. Inā pēlā, e hōʻike ʻo NMN i kahi ʻano hoʻololi metastable e hoʻohaʻahaʻa maʻalahi, ʻo ia hoʻi ka wai i ka huahana a me nā mole wai manuahi i ka lewa e luku pololei i ka kiko isoelectric o ka paʻakai o loko a lawe i lalo i ka maʻemaʻe o NMN. He hopena nui kēia i ka noiʻi paʻa paʻa NMN, kahi e hoʻomaka ai e hoʻomaikaʻi.
I mea e hoʻomaikaʻi ai i ke kūpaʻa o ka pauma NMN i loko, ua hoʻomohala nā mea noiʻi i kahi pauka NMN hou me ka hoʻonohonoho pono a me ka microscopic.
ʻOi aku ka ikaika, ʻoi aku ka lōʻihi o ke ola
ʻOi aku ka pololei a paʻa hoʻi ʻo Phcoker NMN pauma, ka pale pono ʻana i ka pilina me ka wai manuahi i ka lewa, e hoʻonui nui nei i ka paʻa o NMN a hoʻonui i ka ola o ka huahana. Kūlike ʻole i ka puke NMN microscopic hoʻonohonoho, hōʻike ka hana kani kani o ka hanauna mua i ka nui o nā maʻi a me ka incompact, no laila e ʻike ʻia kēlā me kēia mole i ke ea a komo i ka wai hou.
ʻO ke kiʻekiʻena kiʻekiʻe, ʻoi aku ka paʻa o nā ana a me ka formulate maʻalahi.ʻO
ʻO ka pauma NMN me kahi hoʻonohonoho microscopic hoʻonohonoho pono a paʻa ʻia ka nui o ka nui a me ka wai, kahi e pale ai i nā hana kūpaʻa ʻole ma muli o ka hoʻoulu ʻana i ka lepo i ke kaʻina o ka hoʻomākaukau. He aha hou aʻe, e hoʻopili ia i nā huahana o nā capsule. I kēia manawa, ʻoiai he ʻoi aku ka maikaʻi o ka wai, hiki i kā mākou NMN pauka ke kōkua i ka hōʻemi ʻana i ka wā hana a me ke kumukūʻai hana i ka wā o ka hana.
Ua hoʻohiki kiʻekiʻe kiʻekiʻe a me ka maemae
Pono pono nā hōʻike ʻaoʻao hoʻokolohua ʻaoʻao e hōʻoia i ka ʻike a me ka maʻemaʻe o NNM. Pono e hala kēlā me kēia pūʻulu o nā mea maka pono i ka nānā pono ʻana a me nā hoʻokolohua ʻaoʻao ʻekolu. Hiki i nā hōʻike hōʻike HNMR a me HPLC ke hōʻoia hou i ka ʻoiaʻiʻo, ke kiʻekiʻe kiʻekiʻe a me ka maʻemaʻe o NMN.
ʻO Phcoker ka mea hana pauka Nicotinamide mononucleotide (NMN)
Me ka hale ponoʻī ponoʻī, hiki i kā mākou huahana NMN pauka i kēlā me kēia mahina ma kahi o 2 tone.
noi
Mea hoʻonani maka mea:
ʻO NMN kahi mea i loko o ke kino o nā hunaola, a ʻo NMN kahi mole monomona, ʻike maopopo ʻia ka hopena anti-ʻelemakule, no laila hiki ke hoʻohana ʻia i nā mea maka cosmetic.
Nā huahana mālama ola:
Hiki ke hoʻomākaukau ʻia ka pauka NMN e ka fermentation hū, synthesi kemika a i ʻole ka catalysis in vitro enzymatic.
Hoʻohana ākea NMN i ka ʻoihana olakino.
Reference:
[1] Nicotinamide mononucleotide. Mai Wikipedia, ka puke noiʻi kūʻikena manuahi.2019.
[2] Hoʻolālā Kūlohelohe o Nicotinamide Mononucleotide Mitigates Hoʻololi Kūlohelohe i Hoʻohui ʻia i nā Mice. Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Pūnaewele Metab. 2016 Dec 13.
[3] Ke hoʻohaʻahaʻa nei iā NAD + Hoʻokomo i kahi mokuʻāina Pseudohypoxic e hōʻoki ana i ka Nuclear-Mitochondrial Communication i ka wā o ka ʻelemakule. ʻO Gomes AP, Kumukūʻai NL, Ling AJ, Moslehi JJ, Montgomery MK, Rajman L, White JP, Teodoro JS, Wrann CD, Hubbard BP, Mercken EM, Palmeira CM, de Cabo R, Rolo AP, Turner N, Bell EL, Sinclair DA. Pūnaewele. 2013 Dec 19; 155 (7): 1624-38. hana: 10.1016 / j.cell.2013.11.037.
[4] He Mea Hou — a Huli Hou — Ke kumu o ka ʻelemakule. ʻO David Cameron. Ke Kula Lapaʻau ʻo Harvard, Nūhou & noiʻi, Kekemapa 19, 2013
[5] Mālama ʻia kahi ʻeke hoʻopaʻa paʻa ʻo NAD + i kaohi i nā pilina protein-protein i ka wā ʻelemakule. Li J, Bonkowski MS, Moniot S, Zhang D, Hubbard BP, Ling AJ, Rajman LA, Qin B, Lou Z, Gorbunova V, Aravind L, Steegborn C, Sinclair DA. ʻEpekema. 2017 Mar 24; 355 (6331): 1312-1317. hana: 10.1126 / ʻepekema.aad8242.
[6] Ka nui o ke kaʻina hana Chromatography no ka hoʻomaʻemaʻe ʻana iā Nicotinamide Mononucleotide (NMN) mai nā Bacterial Cells. ʻO George Cătălin Marinescu, Roua-Gabriela Popescu & Anca Dinischiotu. Hōʻike ʻepekema 8, ʻatikala helu: 4433 (2018).
[7] ʻO Nicotinamide adenine dinucleotide. Mai Wikipedia, ka puke noiʻi kūʻikena manuahi. 2019.
[8] Ka ʻike o ka mea lawe mitochondrial NAD + lawe ma Saccharomyces cerevisiae., Todisco S, Agrimi G, Castegna A, Palmieri F. J Biol Chem. 2006 Ian 20; 281 (3): 1524-31. Epub 2005 Nov 16.
[9] ʻO Katalin Sas, Elza Szabó, László Vécsei. ʻO Mitochondria, ʻo Stress Oxidative a me ka ʻōnaehana Kynurenine, me ka nānā ʻana i ka ʻelemakule a me ka neuroprotection. Molekule, 2018; DOI: 10.3390 / molekola23010191.
[10] ʻO Nicotinamide mononucleotide (NMN) hoʻonui i ka hopena o ka momona o nā mākua i nāʻiole: hoʻohālikelike me ka hoʻoikaika kino. ʻOdin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.
[11] Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon, Shin-ichiro Imai. ʻO Nicotinamide Mononucleotide, kahi Key NAD + Kuwaena, mālama i ka Pathophysiology o Diet- a me Age-Induced Diabetes i nāʻiole. Pūnaewele Metab, 2011; DOI: 10.1016 / j.cmet.2011.08.014.
[12] Nā hana hou anti-Aging: Nicotinamide Mononucleotide (NMN)
