ʻO ka pauma Cycloastragenol

April 17, 2020

ʻO Cycloastragenol kahi huaʻai hou a me ka wā kahiko i loko o ka mākeke.

ʻO ka wikiō Cycloastragenol (78574-94-4) wikiō

Cycloastragenol ka lehu Snāʻike

Product Name ʻO ka pauma Cycloastragenol
Hawaiian Name N / A
'O Synonyms astramembrangenin

cyclogalegigenin

GRN510

ʻO CAG

Kōpana Drug N / A
Kāleka CAS 78574-94-4
InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N
hakakino F'Oula C30H50O5
hakakino Wʻewalu 490.7 g / mole
Monoisotopic Mass 490.365825 g / mole
ʻO ka paila  N / A
Fkū hou Pʻo kaʻaila N / A
ʻO ka Halifa-Ola N / A
kala like 'ole keʻokeʻo e kaomi
Solakino  DMSO: 10 mg / mL, maopopo
Ska hoʻokele Tka mahana  2-8 ° C
Apaukū ʻO Cycloastragenol kahi mea hoʻoikaika i ka telomerase ikaika. Eia kekahi, pili pono i ka anti-kahiko i loko o ka lāʻau lapaʻau kuʻuna.

Overview

ʻO Cycloastragenol kahi huaʻai hou a me ka wā kahiko i loko o ka mākeke. Hoʻohana ʻia ia ma nā pukula skincare nani a me nā hoʻopihapiha. Ua kūʻai kūʻai ʻia ʻo Cycloastragenol i nā mea kanu meaʻai i loko o ʻAmelika i ka makahiki 2007 ma lalo o ka inoa ʻo TA-65, eia ke kumu ʻo TA 65 a ʻo TA65 paha ka inoa maʻamau loa no ka cycloastragenol.

He aha ka Cycloastragenol?

ʻO ka Cycloastragenol kahi molekula i loaʻa mai i ka mea lae a me nā mea ulu a Astragalus. Ua hoʻohana ʻia ka lāʻau laʻa ʻo Astragalus i ka lāʻau lapaʻau Kina no nā kenekulia. Ua ʻōlelo ka poʻe Kina hiki ʻo Astragalus i hoʻolōʻihi i ke ola a ua hoʻohana ʻia ia i ka mālama ʻana i ka palupalu, pālima, ke anu, ka maʻi o ka naʻau a me ka maʻi maʻi.

ʻO Cycloastragenol kekahi o nā mea hana ikaika ma Astragalus. He like me ka like me ka molekuei ʻo Astragaloside IV, akā he liʻiliʻi a ʻoi aku ka nui o ka bioavailable, e hoʻohaʻahaʻa i nā palapala haʻahaʻa. Hoʻohana ʻia ia ma ke ʻano he immunostimulant ma muli o kona hiki ke hoʻonui i ka proliferation T lymphocyte. Eia nō naʻe, ʻo ia nā mea hoʻonaninani kūlohelohe nui e hoʻonui ana i ka manaʻo ʻepekema kaiāulu.

Hoʻoulu ʻo Cycloastragenol i ka hana hou ʻana o ka hōʻino ʻana o DNA ma o ka hoʻoulu ʻana i telomerase, kahi enzyme nucleoprotein e catalyses synthesis a me ka ulu ʻana o telomeric DNA. Hana ʻia nā telomeres i nā filament lahilahi a loaʻa ma ke kihi o nā chromosome. Mālama i ko lākou kūpaʻa hiki i nā pūnaewele ke hōʻalo i ka senescence replicative a me ka hoʻonui palena ʻole ma ʻō aku o ka palena ʻo 'Hayflick'. Pōkole ʻo Telomeres me kēlā me kēia pōʻaiapili o ka mahele o ka pūnaewele, a i ʻole ke hoʻokau ʻia ʻana i ke koʻikoʻi oxidative A hiki i kēia manawa, he ʻano hiki ʻole ke pale ʻia i ka ʻelemakule.

Nā hana hana i nā hana Cycloastragenol

Ua hōʻike ʻia he nui o nā haʻawina e pili ana ka holomua o ka hoʻomake ʻana o nā telomeres i nā maʻi e pili ana i ka nui o nā makahiki (maʻi o ka naʻau, nā kuʻuna, a pēlā pū) Hoʻopili ʻia ʻo Telomeres me kēlā me kēia hualua o ka hoʻokaʻawale o ka cell, a i ʻole a i hoʻokau ʻia i ke kaumaha o oxidative. A hiki i kēia wā, ʻaʻole i hiki i kēia hana ke ʻano o ka ʻōpio.

ʻO Telomerase kahi kaila enanthoprotein e hoʻomōhala i ka synthesis a me ka ulu ʻana o ka telomeric DNA a hoʻoulu i ka hoʻoponopono o ka pōʻino DNA.

Hoʻololi ʻo Cycloastragenol i ka hoʻoulu ʻana i kēia enzyme, no laila e hōʻemi ana i ka pōkole o nā telomeres a hoʻonui pū i kā lākou helu. Ma kēia ala, hiki iā ia ke hoʻolōʻihi i ka telomeres a me kahi hopena, e hoʻolōʻihi i ka ola o ke kelepona.

Ma muli o kona kaupaona haʻahaʻa, hele koke ʻo Cycloastragenol ma ka paia o ka ʻōpū. Hiki i ka assimilation kūpono kūpono i ka hana kiʻekiʻe, ʻoiai ma ka liʻiliʻi haʻahaʻa. Hoʻopili ka hoʻohui ʻia i kēlā me kēia lā i kāna iho, a i ʻole me ka hoʻopili ʻana a i ʻole, astragaloside IV, e kōkua i ka hoʻopaʻa ʻana i ke kahiko a kūlohelohe i ka manaʻolana.

Cycloastragenol maika

ʻO Astragalus membranaceus kekahi o nā mea kanu waiwai nui loa i ka mōʻaukala lāʻau kuʻuna Kina e like me nā lāʻau kūlohelohe e mālama ai i ka luhi, nā maʻi, nā maʻi ʻeha, nā maʻi ʻākala, ka maʻi ahulau, ka maʻi ahupuaʻa, ka lōʻihi o ke ola a me ka Cycloastragenol kahi mole i lawe ʻia mai Astragalus membranaceus herbs. Eia nō naʻe, ʻo nā pōmaikaʻi nui o ka pauka cycloastragenol ka mea anti-ʻelemakule a me nā hopena kākoʻo immune.

Cycloastragenol a me ke kākoʻo palekana

Hiki ke hoʻohana ʻia ʻo Cycloastragenol e pale i ka ʻōnaehana pale, antibacterial, a me antiinflamalamalama, no ka pale ʻana i nā anuanu maʻamau a me nā maʻi o ka papa. Hoʻohana ʻia ia e like me ka mea e hoʻomaikaʻi kino ʻana ma muli o ka hiki ke hoʻoikaika i ka hoʻomaʻemaʻe ʻana o ka T lymphocyte. Eia naʻe, ʻoi aku ka mea o ke kaiāulu ʻepekema ʻoi loa ka makemake o kona kūʻelemakule maikaʻi loa. Paipai ʻo Cycloastragenol i ka DNA e hoʻoponopono i nā pōʻino ma o ka hoʻomaka ʻana me ka telomerase a e ʻae i ka protease nuklea i hoʻopaʻa aku i ka synthesis a me ka ulu ʻana o ka DNA telomere.

Cycloastragenol a me nā anti-kahiko

ʻO ka anti-kahiko ka maikaʻi loa o ka cycloastragenol. ʻAʻole ke kāpae ʻo Cycloastragenol i ka wā ʻōpiopio o ke kanaka, akā ua hoʻonui pū ʻia ka pale huelo, scavenging toxins, mālama i nā puʻukui cardiac, no ka mea nui loa i loaʻa mai ka astragaloside (Astragaloside Ⅳ) hydrolysis.

ʻO nā pono āpau Cycloastragenol

  1. ka pauʻu cycloastragenol ka hopena i ka hoʻomaha ʻana i nā luhi a me ka pale i ke kino mai nā ʻano kaumaha, e pili ana i ke ʻano kino, noʻonoʻo a noʻonoʻo;
  2. ʻO ka poliklo cycloastragenol aia nā antioxidants, ka mea e pale ai i nā pūleʻa i nā hōʻino i hoʻoiho ʻia e nā radical free;
  3. ka hopena o ka cycloastragenol pauku i ka hoʻohaʻahaʻa i ke koko, e hoʻomaʻemaʻe ana i ka maʻi diabetes a me ka pale i nā ate.

Cycloastragenol nā hopena ʻaoʻao poli

Aia i kēia manawa, ʻaʻohe hōʻike a loiloi paha i kahi hopena maikaʻi ʻole a i ʻole contraindication e lawe ana i ka cycloastragenol supplement.

Cycloastragenol supplementing dosage

Ua hoʻohālikelike hou ʻo Cycloastragenol hou a ʻaʻole ia he nui nā mea momona i kū i ka mākeke, ʻaʻohe ʻai manawa i loaʻa. Wahi a ko mākouʻike, e loli ana ka nui o nā hewa me nā kumu like ʻole, nā makahiki. ʻOi aku ka ʻoi o ka cycloastragenol ma mua o Astragaloside IV nona ke ʻano he dosis 50mg i kēlā me kēia lā. ʻOiai no ka cycloastragenol, ʻo ka pali mai 10mg i 50mg ua maikaʻi wale. Pono ka poʻe kahiko e lawe i kahi ʻoi aku o nā pākeke waena. Manaʻo kekahi e hoʻomaka me 5mg i kēlā me kēia lā, a laila hoʻohui malie. ʻOiai he mea kūlohelohe ka cycloastragenol, hiki i kahi manawa ke ʻike ai i nā hopena, e like me ʻeono mahina.

Cycloastragenol maluhia

Ua hōʻike ʻia ʻo Cycloastragenol e kekahi mau mea me he mea lā anti anti age. Hōʻike mua nā haʻawina mua i ka hoʻohiki ʻana, e hōʻike ana i ka hiki ke hoʻonui i ka lōʻihi telomere, eia naʻe i ka nele o ka noiʻi loiloi maikaʻi. Eia kekahi, aia kahi hopohopo e lawe iā Cycloastragenol e hoʻonui i ka hopena o kekahi mau maʻi. Eia nō naʻe, ʻaʻole i hoʻokō nā noiʻi noiʻi i kekahi pilikia o nā maʻi maʻi e pili ana me ka hoʻohana ʻana iā Cycloastragenol.

ʻO Cycloastragenol ke nānā aku me he mea hoʻohiki anti-ʻelemakule hui pū. ʻOiai ʻaʻole i hōʻoia ʻia e hoʻonui i ke ola akā ua hōʻike ʻia e hōʻemi i nā makahiki e pili ana i nā biomarkers. Hoʻohui ʻia ua hōʻike ʻia e hōʻemi i nā hōʻailona o ka ʻelemakule e like me nā laina maikaʻi a me nā wrinkle. Hiki iā ia ke hoʻemi i ka hopena o nā maʻi degenerative e like me Alzheimer, Parkinson's, retinopathies, a me cataract.

Cycloastragenol hoʻohana ka pauku a me ka noi

Hoʻohana ʻia ʻo Cycloastragenol no ka mālama ʻana, kaohi ʻana, ka pale ʻana, a me ka hoʻomaikaʻi ʻana o nā maʻi aʻe, nā kūlana a me nā ʻōuli.

  • li nui
  • Apoptosis
  • ʻO nā haunaele homeostasis
  • Hiki no ke hoʻohana ʻia ʻo Cycloastragenol no nā kumu i ʻike ʻole ʻia ma ʻaneʻi.

Ua hoʻohana ʻia ka paukū cycloastragenol pauka ma lalo nei o nā kahua:

  1. Hoʻohana ʻia ma ka mahinaʻai, ua hoʻohana maʻamau ʻia e like me ka hoʻohui i ka meaʻai;
  2. Hoʻohui i ke kahua huahana olakino, kōkua kēia huakaʻi i ke kino o ke kanaka;
  3. Hoʻohanaʻia ma ke kīleʻa lole, e like me ke ʻano o ka ʻala maka, hiki iā ia ke hoʻohui i kahi lole kūlohelohe.

Reference:

  • ʻO nā kūpuna anti-ʻelemakule o cycloastragenol i hana ʻia e biotransformation. ʻO C C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G.Nat Prod Res. 2019 Sep 9: 1-6. hana: 1080 / 14786419.2019.1662011.
  • Cycloastragenol: He moho puke pīhoihoi no nā maʻi i pili i nā makahiki. Yu Y et al. ʻO Exp Ther Med. (2018) Nā kūnewa kūnewa o ka cycloastragenol i hana ʻia e biotransformation. Chen C, Ni Y, Jiang B, Yan S, Xu B, Fan B, Huang H, Chen G. Nat Prod Res. 2019 Sep 9: 1-6. hana: 10.1080 / 14786419.2019.1662011
  • Hiki i ka Cycloastragenol ke hōʻole i ka hoʻokumu STAT3 hoʻokumu a hoʻolaha i ka apoptosis i hoʻokomo ʻia i paclitaxel i loko o nā hale maʻi maʻi ʻōpū kanaka. ʻO Hwang ST, Kim C, Lee JH, Chinnathambi A, Alharbi SA, Shair OHM, Sethi G, Ahn KS. 2019 Iune
  • ʻO Astragaloside VI a me cycloastragenol-6-O-beta-D-glucoside e hoʻolaha i ka hōʻeha hōʻeha i ka vitro a ma vivo.Lee SY et al. ʻO Phytomedicine. (2018)