Nicotinamide adenine dinucleotide (53-84-9) wikiō
ʻO Nicotinamide adenine dinucleotide (53-84-9) Snāʻike
| Product Name | Nicotinamide adenine dinucleotide (NAD +) |
| Hawaiian Name | Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride; |
| Kāleka CAS | 53-84-9 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| Ka Lā Molecular | C21H27N7O14P2 |
| Molecular Weight | 663.4 g / mole |
| Monoisotopic Mass | 663.109123 g / mole |
| Point Hoʻolālā | 160 ° C (320 ° F; 433 K) |
| kala like 'ole | Keʻokeʻo |
| Shoʻoweliweli temp | 2-8 ° C |
| Palekana | H2O: 50 mg / mL |
| noi | ʻOka meaʻai maikaʻi, ke olakino, pili hoʻohui |
He aha ʻO Nicotinamide adenine dinucleotide(NAD +)?
ʻO Nicotinamide adenine dinucleotide (NAD) he cofactor e kōkua ana i ka metabolism i loaʻa i loko o nā papa ola. Aia i loko oʻelua mau puka, oxidized (NAD +) a hōʻemi (NADH).
ʻO Coenzyme NAD +, ka mea i hoʻopihapiha ʻia o NAD, i loaʻa mua i ka 1906 e nā biochemists Pelekane Arthur Harden a me William John Young. Hoʻolāʻau ʻia ʻo NAD + e ʻelua ala kakano, kahi hiki ke hoʻopuka ʻia mai ke ala acid acid de de novo amino, a i ʻole ke hana ʻia e ka hana hou ʻana i nā mea i hana mua ʻia (e like me ka nicotinamide) hoʻi i ke ala hoʻopakele o NAD +. He mea nui ia e ka pyridine nucleotide a lawelawe pono i ka cofactor pono a me ka substrate no nā nui o ka nui o nā ʻōnaehana nui e pili ana i ka oxidative phosphorylation a me ka hana ATP, hoʻoponopono DNA, hoʻoponopono epigenetic o ka hōʻike ira, intracellular calcium hōʻailona a me ka hana Immunological.
ʻO NAD + ka molekone o ka molekohu electron nui i nā oxidation koiola. Loaʻa ia i nā electrons mai nā molekole ʻē aʻe a hoʻemi ʻia. Hoʻohana ʻia ka mea hoʻohālikelike o ka hydrase transferase a me kahi substrate e hoʻopau i ka polyADase NAD (+) a ʻano hana i kahi pālua reden come me ka hoʻēmi ʻia β-nicotinamide adenine dinucleotide (NADH). ʻO NAD (R) ka pūʻulu a me ka mea i hāʻawi ʻia i ka ADP-ribose i ka ADP-A. ʻO kahi mua hoʻi i mua o ka cyclic ADP-ribose (ADP-ribosyl cyclase).
Ma ke ʻano he oxidant i ka pūnao pūnaehana, hana pū kekahi ʻo NAD (R) i ka adenosine diphosphate (ADP) -ribose hoʻololi i nā hopena e pili ana i kahi polymerase diadenylate (ADP-ribose) a me kekahi mau ʻano hana ʻē aʻe. Hiki iā ia ke hāʻawi pale aku iā NAD e pale a hōʻemi paha i ka maʻi kō, ka maʻi ʻaʻai a me nā maʻi ʻē aʻe e pili ana i ka makahiki. Eia nō naʻe, hiki i nā mea hoʻouluulu NAD + ke hana synergistically me nā mea hoʻopihapiha e like me resveratrol e kōkua hou i ka mitochondria a hakakā i nā maʻi ʻelemakule.
ʻO Nicotinamide adenine dinucleotide(NAD +) pōmaikaʻi
Ma ke ʻano he oxidant maikaʻi, hōʻike ʻo Nicotinamide adenine dinucleotide i kekahi mau pono maikaʻi i nā hana kanaka.
♦ Optimize i kāu hana kelepona,
♦ Hoʻonui i kou ikehu kūlohelohe;
♦ Hoʻonui i ka hana o ka lolo, ka noʻonoʻo a me ka hoʻomanaʻo;
♦ Hoʻonui i kāu metabolism;
♦ Hoʻonui i ka hiamoe;
♦ Hoʻonui i ka hana sirtuin honua;
♦ Hoʻonui i ka pono antioxidant;
♦ Hoʻoemi i ka pehu;
♦ Hoʻonui i ke kaulike, ke ʻano, ka hihiʻo a me ka hoʻolohe ʻana;
ʻO Nicotinamide adenine dinucleotid kahi pahuhopu pololei hoʻi o ka lāʻau isoniazid, i hoʻohana ʻia i ka mālama ʻana i ka tuberculosis, kahi maʻi i hoʻokumu ʻia e Mycobacterium tuberculosis. I hoʻokahi hoʻokolohua, ua hāʻawi ʻia nā ʻiole i hāʻawi ʻia iā NAD no hoʻokahi pule i hoʻomaikaʻi i ke kamaʻilio nukle-mitochrondrial.
Eia kekahi, loaʻa iā Nikotinamide adenine dinucleotide (NAD +) ka pale a me ka mālama ʻana o ka poloka puʻuwai, sinus node function a me nā hoʻokani anti-wikiwiki hoʻokolohua, hiki i ka nicotinamide ke hoʻomaikaʻi maikaʻi i ka puʻuwai o ka puʻuwai a me ka atriove ntricular block i hoʻokumu ʻia e verapamil.
ʻO Nicotinamide adenine dinucleotide(NAD +) noi:
- Diagnostic reagents mau maka maka, hoʻāʻo ʻana ʻepekema noiʻi.
- ʻOka meaʻai maikaʻi, ke olakino, pili hoʻohui
- Hoʻoulu API
More ʻO Nicotinamide adenine dinucleotide(NAD +) noiʻi
ʻO nā enzyme e hana a hoʻohana i ka NAD + a me ka NADH he mea nui i nā lāʻau lapaʻau ʻelua a me ka noiʻi ʻana i nā mālama e hiki mai ana no ka maʻi. ʻAʻole hoʻohana ʻia ʻo coenzyme NAD + i kēia manawa ma ke ʻano he lapaʻau no nā maʻi āpau. Eia nō naʻe, ke aʻo ʻia nei no ka hoʻohana kūpono i ka hoʻōla o nā maʻi neurodegenerative e like me ka maʻi Alzheimer a me Parkarkinson.
Reference:
- Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism i ke olakino a me nā maʻi" (PDF). ʻO Biochem Trends. ʻO Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Archive from the original (PDF) on 4 July 2009. Ua kiʻi ʻia 23 December 2007.
- ʻO Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Ka ʻike o ka mitochondrial NAD + transporter ma Saccharomyces cerevisiae". J. Biol. Kemika 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
- Lin SJ, Guarente L (ʻApelila 2003). "Nicotinamide adenine dinucleotide, kahi metabolic regulator o ka palapala, ka lōʻihi a me ka maʻi". Pākuʻi Manaʻo Manaʻo. Pūnaewele Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
- Williamson DH, Lund P, Krebs HA (1967). "Ke kūlana redox o ka nikotinamide-adenine dinucleotide manuahi i ka cytoplasm a me ka mitochondria o ka ʻiole ʻiole". ʻO Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
- Foster JW, Moat AG (1 Malaki 1980). "Nicotinamide adenine dinucleotide biosynthesis a me pyridine nucleotide cycle metabolism i loko o nā ʻōnaehana microbial". ʻO Mikrobiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
- Palani Palani. ʻO ka inu ʻana i ka wai ʻona mau e hōʻeha ai i ke ake a me nā mea ʻē aʻe e ka hōʻemi ʻana i nā pae NAD⁺ e pono ai no ka hana deacetylase a sirtuin. Exp Mol Pathol. 2016 ʻApel; 100 (2): 303-6. hana: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Pepeluali 16. PMID: 26896648.
- Kane AE, Sinclair DA. ʻO Sirtuins a me NAD + i ka hoʻomohala a me ka mālamaʻana i nā maʻi o ka metabolic a me nā maʻi Cardiovascular. Kaʻi Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.
