Nicotinamide adenine dinucleotide (53-84-9)

March 15, 2020
SKU: 53-84-9
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ʻO Nicotinamide adenine dinucleotide (NAD) he cofactor e kōkua ana i ka metabolism i loaʻa i loko o nā papa ola. Aia i ʻelua mau ʻano ...….


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Nicotinamide adenine dinucleotide (53-84-9) wikiō

Nicotinamide adenine dinucleotide (53-84-9) Snāʻike

Product Name Nicotinamide adenine dinucleotide (NAD +)
Hawaiian Name Nadide; coenzyme I; beta-NAD; beta-NAD +; beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide; Enzopride;
Kāleka CAS 53-84-9
InChIKey BAWFJGJZGIEFAR-NNYOXOHSSA-N
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N
Ka Lā Molecular C21H27N7O14P2
Molecular Weight 663.4 g / mole
Monoisotopic Mass 663.109123 g / mole
Point Hoʻolālā 160 ° C (320 ° F; 433 K)
kala like 'ole Keʻokeʻo
Shoʻoweliweli temp 2-8 ° C
Palekana H2O: 50 mg / mL
noi ʻOka meaʻai maikaʻi, ke olakino, pili hoʻohui

He aha Nicotinamide adenine dinucleotide(NAD +)?

ʻO Nicotinamide adenine dinucleotide (NAD) he cofactor e kōkua ana i ka metabolism i loaʻa i loko o nā papa ola. Aia i loko oʻelua mau puka, oxidized (NAD +) a hōʻemi (NADH).

ʻO Coenzyme NAD +, ka mea i hoʻopihapiha ʻia o NAD, i loaʻa mua i ka 1906 e nā biochemists Pelekane Arthur Harden a me William John Young. Hoʻolāʻau ʻia ʻo NAD + e ʻelua ala kakano, kahi hiki ke hoʻopuka ʻia mai ke ala acid acid de de novo amino, a i ʻole ke hana ʻia e ka hana hou ʻana i nā mea i hana mua ʻia (e like me ka nicotinamide) hoʻi i ke ala hoʻopakele o NAD +. He mea nui ia e ka pyridine nucleotide a lawelawe pono i ka cofactor pono a me ka substrate no nā nui o ka nui o nā ʻōnaehana nui e pili ana i ka oxidative phosphorylation a me ka hana ATP, hoʻoponopono DNA, hoʻoponopono epigenetic o ka hōʻike ira, intracellular calcium hōʻailona a me ka hana Immunological.

ʻO NAD + ka molekone o ka molekohu electron nui i nā oxidation koiola. Loaʻa ia i nā electrons mai nā molekole ʻē aʻe a hoʻemi ʻia. Hoʻohana ʻia ka mea hoʻohālikelike o ka hydrase transferase a me kahi substrate e hoʻopau i ka polyADase NAD (+) a ʻano hana i kahi pālua reden come me ka hoʻēmi ʻia β-nicotinamide adenine dinucleotide (NADH). ʻO NAD (R) ka pūʻulu a me ka mea i hāʻawi ʻia i ka ADP-ribose i ka ADP-A. ʻO kahi mua hoʻi i mua o ka cyclic ADP-ribose (ADP-ribosyl cyclase).

E like me ka mea ʻaihue i loko o nā hana metabolism, ʻo NAD (R) hana pū kekahi i ka adenosine diphosphate (ADP) -hōkō i ka hoʻololi e pili ana i kahi polyenyase a diadenylate (ADP-ribose) a me kekahi mau kaʻina hana enzymatic. Hiki iā ia ke pale aku i ka NAD i pale a hōʻemi paha i ka maʻi maʻi, nā maʻi a me nā maʻi ʻē aʻe. Eia kekahi, hiki i ka mea hana ʻo NAD + ke hana me ka synergistically me nā mea hoʻohui e like me resveratrol e kōkua i ka hoʻoulu mitochondria a hakakā i nā maʻi ʻōpiopio.

Nicotinamide adenine dinucleotide(NAD +) pōmaikaʻi

Ma ke ʻano he oxidant maikaʻi, hōʻike ʻo Nicotinamide adenine dinucleotide i kekahi mau pono maikaʻi i nā hana kanaka.

♦ Hoʻonui i kāu hana cellular,

♦ E hoʻonui i kou ikehu maoli;

♦ E hoʻomaikaʻi i ka hana noʻonoʻo, nānā a me ka hoʻomanaʻo;

♦ Hoʻonui i kou kaohiʻana;

♦ E hoʻomaikaʻi i ka hiamoe;

♦ Hoʻoulu i ka hana sirtuin honua;

♦ E hoʻomaikaʻi i ka hoʻomaʻamaʻa antioxidant;

♦ E hōʻemi i ka mumū;

♦ Maikaʻi ka kaulike, ka naʻau, ka ʻike a me ka lohe;

ʻO Nicotinamide adenine dinucleotid kekahi i ka kuhikuhi pono i ka isoniazid lāʻau, ka mea i hoʻohana ʻia i ka mālama ʻana o thetuberculosis, kahi maʻi maʻi i ka maʻi Mycobacterium tuberkulosis. I ka hoʻokolohua hoʻokahi, ua hoʻomaikaʻi ʻia nā kiʻī i hāʻawi ʻia ʻo NAD no hoʻokahi pule.

Eia kekahi, loaʻa iā Nikotinamide adenine dinucleotide (NAD +) ka pale a me ka mālama ʻana o ka poloka puʻuwai, sinus node function a me nā hoʻokani anti-wikiwiki hoʻokolohua, hiki i ka nicotinamide ke hoʻomaikaʻi maikaʻi i ka puʻuwai o ka puʻuwai a me ka atriove ntricular block i hoʻokumu ʻia e verapamil.

Nicotinamide adenine dinucleotide(NAD +) noi:

  1. Diagnostic reagents mau maka maka, hoʻāʻo ʻana ʻepekema noiʻi.
  2. ʻOka meaʻai maikaʻi, ke olakino, pili hoʻohui
  3. Hoʻoulu API

More Nicotinamide adenine dinucleotide(NAD +) noiʻi

ʻO nā kumuhana e hana a hoʻohana iā NAD + a me NADH i mea nui ma ka lāʻau lapaʻau a me ka noiʻi ʻana i nā hana e hiki mai ana no ka maʻi. ʻAʻole i hoʻohana ʻia ka coenzyme NAD + i kēia manawa ma ke ʻano he lāʻau lapaʻau no kekahi maʻi. Eia nō naʻe, ke noiʻi ʻia nei no kona hiki ke hoʻohana i ka hopena o ka maʻi neurodegenerative e like meAlzheimer andParkinson maʻi.

Reference:

  • Belenky P, Bogan KL, Brenner C (2007). "NAD + metabolism i ke olakino a me nā maʻi" (PDF). Nā Kāleka Biochem. Sci. 32 (1): 12– doi: 10.1016 / j.tibs.2006.11.006. PMID 17161604. Loaʻa ʻia mai ka mua (PDF) ma ka 4 Iulai 2009. Ua loaʻa i ka 23 December 2007.
  • Todisco S, Agrimi G, Castegna A, Palmieri F (2006). "Ka ʻike o ka transitter mitochondrial NAD + ma Saccharomyces cerevisiae". J. Biol. ʻĀlelo. 281 (3): 1524– doi: 10.1074 / jbc.M510425200. PMID 16291748.
  • Lin SJ, Guarente L (ʻApelila 2003). "ʻO Nicotinamide adenine dinucleotide, kahi loea metabolic o ka transcription, lōʻihi lōʻihi a me nā maʻi". Curr. ʻOlama. Pūnaewele Biol. 15 (2): 241– doi: 10.1016 / S0955-0674 (03) 00006-1. PMID 12648681.
  • Williamson DH, Lund P, Krebs HA (1967). "ʻO ka mokuahi redox o ka nicotinamide-adenine dinucleotide ma ka cytoplasm a me ka mitochondria o nā pepelu moliki". ʻO Biochem. J. 103 (2): 514– doi: 10.1042 / bj1030514. PMC 1270436. PMID 4291787.
  • Foster JW, Moat AG (1 Malaki 1980). "Nicotinamide adenine dinucleotide biosynthesis a me ka pyridine nucleotide cycle metabolism i loko o nā ʻōnaehana microbial". Nā Microbiol. Rev. 44 (1): 83– PMC 373235. PMID 6997723.
  • Wīwī SW. Hoʻomaʻamaʻa ka ʻalohi maʻi i nā momona a me nā kino ʻē aʻe ma o ka hōʻemi ʻana i nā pae NAD⁺ e pono ai no ka hana deacetylase sirtuin. Exp Mol Kōpila. 2016 Apr; 100 (2): 303-6. doi: 10.1016 / j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
  • Kane AE, Sinclair DA. ʻO Sirtuins a me NAD + i ka hoʻomohala a me ka mālamaʻana i nā maʻi o ka metabolic a me nā maʻi Cardiovascular. Kaʻi Res. 2018 Sep 14; 123 (7): 868-885. doi: 10.1161 / CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.