ʻO ka māmā Lorcaserin HCL kalo (846589-98-8)

'Okakopa 30, 2018
SKU: 846589-98-8

ʻO ka Raw Lorcaserin hydrochloride paukū kahi agotonista serotonin 2C (5-HT2C) a hāʻawi ʻia i ka lāʻau i hoʻolaha ʻia….


Kūlana: I ka Production Production
Mokuna: 25kg / Drum
nona iho: 1380kg / ka mahina

ʻO ka paʻiʻo Lorkerin HCL (846589-98-8) wikiō

 

ʻO ka māmā Lorkaserin HCL pauka (846589-98-8) Hōʻike

Product Name ʻO Raw Lorcaserin ka lepo
Hawaiian Name ʻO ka Rack Lorcaserin HCL kalo, Lorcaserin
Brand Name KANAWAI
Kōpana Drug XINUM-HT5C mea hoʻonāuki loaʻa
Kāleka CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
hakakino F'Oula C11H15Cl2N
hakakino Wʻewalu 232.15
Monoisotopic Mass 231.058154899
Hoʻolaha Pʻo kaʻaila  ʻAʻoheʻikepili i loaʻa
Fkū hou Pʻo kaʻaila ʻAʻoheʻikepili i loaʻa
ʻO ka Halifa-Ola ʻO ka hapalua o ka lorcaserin he mau hola 11 ia. Hoʻopau loaʻia ka lepo i ka urine (92%) a me nā feces (2.2%)
kala like 'ole ʻO ka pauma
Palekana  Waiwai Kūmole: 0.0709 mg / mL
pūnaewele Tka mahana  -20 ° C.
Apaukū Nero o kaʻenehana receptor 2C (HT2C) no ka pohō kaumaha. Hoʻemiʻia ka meaʻai a hoʻolaha i ka noho'eneʻolu ma waena

 

ʻO Raw Lorcaserin Hcl kala (846589-98-8) Hōʻike

ʻO ka Raw Lorcaserin hydrochloride paukū kahi hydrochloride i loaʻa i ka hopena o ka paukū lorcaserin me kahi like o ka waikawa hydrochloric. Hoʻohana ʻia e like me kahi lāʻau anti-obesity. ʻO Lorcaserin hydrochloride kahi ageptist reseptor 5HT2c i hōʻike ʻia no ka hoʻohana ʻana i nā mākua me ka BMI ≥30, a i ʻole nā ​​mea me ka BMI ≥27 a ma kahi o hoʻokahi kūlana e pili ana i ke kaupaona e like me ka hypertension, ʻano diabetes 2 a i ʻole dislipidemia. hoʻoulu i ka manaʻo o ka māʻona, a manaʻo ʻia e pale i ka heleleʻi ʻana o ka maʻi valvular cardiac e pili ana me ka hoʻoulu ʻana o nā mea loaʻa he 5-HT2B, kahi o ka lolo i ʻike ʻia he kuleana nui i ka hoʻoponopono ʻana i ka pōloli a me ka ʻai. Ma ka hoʻoulu ʻana i kēia mau mea loaʻa, hiki i ka Lorcaserin hydrochloride pauka ke hoʻemi i ka ʻai ma ka hōʻemi ʻana i ka makemake a me ka hōʻona ʻana i kekahi kanaka ma hope o ka ʻai ʻana i ka meaʻai ma mua o ka maʻamau. ua ʻae ʻia e ka FDA i kēia lā i kahi hoʻoholo palena ʻāina ma hope o 2 mau makahiki o ka nānā ʻana.

Hoʻohālikelikeʻiaʻo Lorcaserin hydrochloride ka pauku i mea hoʻokūʻai i ka mea hoʻemiʻia kalolo a me ka hoʻonuiʻana i ka hoʻolālā kino no ka hoʻomaluʻana i ka hana kaumaha i nā mea maʻamau (BMI o 30 kg / m2 aʻoi aʻe) a me ka poʻe keu (BMI o 27 kg / m2 aʻoi aku paha) me ka liʻiliʻi o hoʻokahi kūlana pili pili i ke kaumaha.

Hoʻohanaʻiaʻo Lorcaserin hydrochloride me kaʻai a me ka hana e mālama ai i ka momona. I kekahi manawa hoʻohanaʻia e mālama i ka momona e pili ana i ka maʻi diabetes, ke kiʻekiʻe o ka cholesterol, aiʻole ke koko kiʻekiʻe.

ʻAʻole e hoʻokaeʻia ka maʻi olakinoʻo Lorcaserin hydrochloride (e like me ka maʻi o ka maʻi, ka maʻi hīkī, ke koko kiʻekiʻe). E mālama i kekahi mau lāʻau'ē aʻe a kāu kauka i kauoha ai e mālama i kēia mauʻano.

Lorcaserin Hcl pauki (846589-98-8) Mechanism of Action

ʻOiai keʻikeʻoleʻia ka mechanical like, ua manaʻoʻia ua hoʻokomoʻia ka hoʻouluʻana o nā nūhou 5-HT2C i nā neuxigenic pro-opiomelanocortin neurons i ka piko o ka hypothalamus. ʻO kēia ka hopena o ka hoʻemiʻiaʻana o kaʻai a me ka mālie ma o ka hoʻonāʻana i ka hoʻokuʻuʻana i ka hormone hoʻonani alpha-melanocortin, e hana nei ma nā mīkini melanocortin-4.

Hana ʻo Lorcaserin hydrochloride pauma e ka kaohi ʻana i ka makemake - kikoʻī ma ka hoʻoulu ʻana i nā mea loaʻa ka lolo no serotonin, kahi neurotransmitter e hoʻonāukiuki i nā manaʻo o ka māʻona a me ka ʻoluʻolu. Hoʻokomo ʻia ka ʻai o ka meaʻai e ke kikowaena satiety, aia i loko o ka nucleus ventromedial o hypothalamus a me kahi kikowaena pololi i loaʻa i ka hypothalamus pili. Hoʻopili nā ʻano komo like ʻole mai nā kikowaena kiʻekiʻe a me nā ʻōpū o ka gastrointestinal i ka nucleus arcuate, kahi ʻelua ʻano o nā neurons e kāohi ana i ka ʻai i loaʻa. ʻO ka mea mua, ʻo ka pūʻulu stimulateʻai e hana ana i nā protein e pili ana i ka agouti a me ka neuropeptide Y; a ʻo ka lua, ʻo ka pūʻulu mea hoʻokomo i ka meaʻai e loaʻa ana ka cocaine a me ka amphetamine regulated transcript (CART) a me nā neurons pro-opiomelanocortin (POMC). Loaʻa i ka POMC nā mea loaʻa he 5-HT 2C, a ke hoʻoulu ʻia e hoʻokuʻu i ka hormone alpha-melanocyte-stimulate (alfa-MSH). ʻO nā neurons inhibitory ʻelua a hoʻonāukiuki hou nā papahana paraventricular nucleus i ka hypothalamus. Aia i loko o ka Paraventricular nucleus nā melanocyte 4 mau mea loaʻa (MC4R) e kāohi ai i ka makemake i nā lāʻau lapaʻau lorcaserin hydrochloride paukū e hana ma ke ʻano he agonist 5-HT 2C i koho ʻia ma nā neurons POMC, a ʻo ia hoʻi ka mea e hoʻokuʻu ai i ka alfa MSH. Hana ʻo alfa MSH hou aʻe ma MC4R i nā paraventricular nucleus i ka hypothalamus, e alakaʻi ana i ka hōʻemi ʻana i ka makemake. I nā mahele supratherapeutic, hana pū kekahi ʻo lorcaserin hydrochlorider ma nā mea loaʻa ʻo 5-HT 2B a me 5-HT 2A.

maika o ka paʻiʻo Lorcaserin Hcl (846589-98-8)

  • ʻO ka momonaʻo Lorcaserin HCL he mea'āpana agonistʻo 5-HT2C i kohoʻia e emi ana kaʻaiʻana ma o ka pūnaewele POMC pūnaewele. ʻO ka loliʻo Lorcaserin HCL:
  • Hoʻopiliʻia ka'opiʻo Lorcaserin HCL me kaʻai a me ka hoʻomehana e mālama i ka momona.
  • Hoʻohanaʻiaʻo Copacaca HCL i kekahi manawa no ka mālamaʻana i ka momona e pili ana i ka maʻi diabetes, high cholesterol, aiʻole ke koko kiʻekiʻe.
  • ʻAʻole hiki i ka Lorcaserin HCL kahe e mālama i kekahi maʻi olakino (e like me ka maʻi o ka maʻi, ka maʻi hīkī, ke koko kiʻekiʻe).

Hōʻoiaʻia ka'ōlelo Malakenaʻo Hcl (846589-98-8) Hana

Hiki mai ka pauka Lorcaserin HCL i ka papa papa a lawe maʻamau ʻia he 1-2 mau manawa i ka lā, me ka ʻai ʻole. Pono e hoʻohana ʻia ʻo Lorcaserin me kahi papa calorie hoʻemi ʻia a me kahi hoʻolālā hoʻoikaika kino.

ʻO ka mahele lāʻau i koi ʻia o ka lorcaserin hcl pauka ka 10 mg i lawelawe ʻia e ka waha i ʻelua mau lā i ka lā. Lawe ʻia ʻo Lorcaserin me ka nānā ʻole i nā meaʻai. Pono e hoʻopau ʻia ʻo Lorcaserin hcl i nā mea maʻi i kūleʻa ʻole e loaʻa ma kahi o 5% ka pohō kaumaha ma o ka pule 12 no ka mea ʻaʻole paha e ʻike kēia mau maʻi i ka pohō kaumaha me ka hoʻomau ʻana i ka lāʻau.

Nā hopenaʻaoʻao o ka paʻiʻo Lorcaserin Hcl (846589-98-8)

Hoʻohana ʻia ʻo Lorcaserin Hcl pauma no ka mālama ʻana i ka mālama ʻana i nā kaumaha mau i nā mākua me ka papa kuhikuhi kino (BMI) o 30 a ʻoi aku paha (obese) ma ke ʻano he hoʻohui i ka ʻai hoʻoliʻiliʻi a me ka hoʻoikaika kino. Ua ʻae ʻia no ka hoʻohana ʻia e nā mākua me ka BMI o 27 a ʻoi paha (ʻoi o ke kaupaona) a i loaʻa i hoʻokahi o nā kūlana e pili ana i ke kaupaona e like me ke koko kiʻekiʻe (hypertension), a i ʻole ke kiʻekiʻe o ke kolesterol (dislipidemia). Eia nō naʻe, he hopena ʻē aʻe paha ia. E like me lalo:

 Tnā hopena hopena maʻamau:

  • ʻO Headache,
  • -Ka nui,
  • Ka hoʻouluʻana,
  • -Nausea,
  • ʻO ka waha,
  • -Kauwai, a
  • 'OHypoglycemia (ke koko blood nui).

 ʻO nā hopena'ē aʻe o nā hopena maʻamau a piliʻole i pili i ka lorcaserin, penei:

  • ʻO nā pilikia pilikia o ka hoʻopuka pale,
  • -Naʻoʻana i ka nānā a iʻole ka hoʻomanaʻo,
  • Nā pilikia pilikia,
  • -Ke hōʻeuʻeu aiʻole manaʻo no ke olaʻana,
  • -No nā'ōlelo hoʻokūkū,
  • -Ke hoʻokipa naʻauʻole,
  • -E hoʻokuʻu i nā helu pūnaewele koko, a
  • ʻO ka hoʻonuiʻana i ka hormone, prolactin.