ʻO ka māmā Lorcaserin HCL kalo (846589-98-8)

'Okakopa 30, 2018
SKU: 846589-98-8

ʻO Raw Lorcaserin ka lepo a me kaʻeleʻeleʻo 2C (5-HT2C) a me ka lawelaweʻana i nā lāʻau lapaʻau e hoʻolaha ....


Kūlana: I ka Production Production
Mokuna: 25kg / Drum
nona iho: 1380kg / ka mahina

ʻO ka paʻiʻo Lorkerin HCL (846589-98-8) wikiō

ʻO ka māmā Lorkaserin HCL pauka (846589-98-8) Hōʻike

Product Name ʻO Raw Lorcaserin ka lepo
Hawaiian Name ʻO ka Rack Lorcaserin HCL kalo, Lorcaserin
Brand Name KANAWAI
Kōpana Drug XINUM-HT5C mea hoʻonāuki loaʻa
Kāleka CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
hakakino F'Oula C11H15Cl2N
hakakino Wʻewalu 232.15
Monoisotopic Mass 231.058154899
Hoʻolaha Pʻo kaʻaila ʻAʻoheʻikepili i loaʻa
Fkū hou Pʻo kaʻaila ʻAʻoheʻikepili i loaʻa
ʻO ka Halifa-Ola ʻO ka hapalua o ka lorcaserin he mau hola 11 ia. Hoʻopau loaʻia ka lepo i ka urine (92%) a me nā feces (2.2%)
kala like 'ole ʻO ka pauma
Palekana Waiwai Kūmole: 0.0709 mg / mL
pūnaewele Tka mahana -20 ° C.
Apaukū Nero o kaʻenehana receptor 2C (HT2C) no ka pohō kaumaha. Hoʻemiʻia ka meaʻai a hoʻolaha i ka noho'eneʻolu ma waena

ʻO Raw Lorcaserin Hcl kala (846589-98-8) Hōʻike

ʻO kaʻikeʻo Lorkaserin ka waikahu wai ka wai e loaʻa i ka hopena o ka paukū me ka mea like me ka waika hydrochloric. Hoʻohanaʻiaʻo ia he lāʻau lapaʻau. Lorcaserin hydrochloride he agonist receptor 5HT2c i hōʻikeʻia no ka hoʻohanaʻana i nā mākua me ka BMI ≥30, a me nā mea me ka BMI ≥27 a me ka liʻiliʻi hoʻokahiʻano pilikino e like me ka hanu kiʻekiʻe, ka maʻi maʻamau o 2 a dyslipidemia paha. Hoʻokumu i ka leʻaleʻa, a manaʻoʻia e pale i ka pīpī o ka maʻi valvular naʻaupō e pili ana i ka hoʻouluʻana o nā mea hōʻailona 5-HT2B, kahi o ka lolo iʻikeʻia e pāʻani i kaʻai a me kaʻai. Ma ka hoʻonāʻana i kēia mau loea, hiki ke hoʻoemi i kaʻai ma muli o ka hoʻohaʻahaʻaʻana i kaʻai a me ka hoʻonaʻauaoʻana i ke kanaka ma hope o kaʻaiʻana i ka meaʻai ma mua o ka mea maʻamau. uaʻaeʻia i kēia lā e ka FDA ma kahi hoʻoholo koho i ka paukū 2 mau makahiki i kohoʻia.

Hoʻohālikelikeʻiaʻo Lorcaserin hydrochloride ka pauku i mea hoʻokūʻai i ka mea hoʻemiʻia kalolo a me ka hoʻonuiʻana i ka hoʻolālā kino no ka hoʻomaluʻana i ka hana kaumaha i nā mea maʻamau (BMI o 30 kg / m2 aʻoi aʻe) a me ka poʻe keu (BMI o 27 kg / m2 aʻoi aku paha) me ka liʻiliʻi o hoʻokahi kūlana pili pili i ke kaumaha.

Hoʻohanaʻiaʻo Lorcaserin hydrochloride me kaʻai a me ka hana e mālama ai i ka momona. I kekahi manawa hoʻohanaʻia e mālama i ka momona e pili ana i ka maʻi diabetes, ke kiʻekiʻe o ka cholesterol, aiʻole ke koko kiʻekiʻe.

ʻAʻole e hoʻokaeʻia ka maʻi olakinoʻo Lorcaserin hydrochloride (e like me ka maʻi o ka maʻi, ka maʻi hīkī, ke koko kiʻekiʻe). E mālama i kekahi mau lāʻau'ē aʻe a kāu kauka i kauoha ai e mālama i kēia mauʻano.

Lorcaserin Hcl pauki (846589-98-8) Mechanism of Action

ʻOiai keʻikeʻoleʻia ka mechanical like, ua manaʻoʻia ua hoʻokomoʻia ka hoʻouluʻana o nā nūhou 5-HT2C i nā neuxigenic pro-opiomelanocortin neurons i ka piko o ka hypothalamus. ʻO kēia ka hopena o ka hoʻemiʻiaʻana o kaʻai a me ka mālie ma o ka hoʻonāʻana i ka hoʻokuʻuʻana i ka hormone hoʻonani alpha-melanocortin, e hana nei ma nā mīkini melanocortin-4.

Lorcaserin hydrochloride lepo e hana ana ma o ka hoʻonāʻana i ka manaʻo - ma ka hoʻonāʻana i nā nānā i ka lolo no ka serotonin, kahi neurotransmitter e hoʻopiʻi ai i ka hauʻoli a me kaʻoluʻolu. ʻO ka mālamaʻana i kaʻai e hoʻomaluʻia e kahi kikowaena kikowaena, kahi i loko o ka pūnana ventromedial o hypothalamus a me ka haleʻai make ma ka piko hypothalamus. Ke kuhi nei nāʻano kikowaena mai nā kikowaena kiʻekiʻe a me nā puke āpau e pili ana i ka piko nucleus, kahi e noho aiʻeluaʻano neurons e mālama ana i kaʻai. ʻO ka mea mua, nā pūʻulu hoʻoulu o ka meaʻai e hana ana i ka protein a me ke neuropeptide Y. aʻo ka lua, heʻaha hoʻopunipuniʻai i loko o ka cocaine a me ka amphetamine (transca) (CART) a me pro-opiomelanocortin (POMC) neurons. POMC loaʻa nā hōʻailonaʻo 5-HT 2C, i ka wā e hoʻopiliʻia ai ka hormone alpha-melanocyte-stimulating (alfa-MSH) .Paʻani āpau a me nā mea hoʻonāuki e hoʻolālā hou i nā nucleus āpau i ka hypothalamus. ʻO ka pūnaewele hōʻokoʻa he mau mīkini helu 4 melanocyte (MC4R) ka mea e hoʻoneʻe ai i ka makemake i nā kohu lāʻau lorcaserin hydrochloride paukū e hana ana i ka neerons 5-HT 2C maʻamau i nā neurons POMC, aʻo ia ke kumu no ka hoʻokuʻuʻana o alfa MSH. ʻO nā hana'ē aʻe a MSH e hana nei ma MC4R i loko o ka nucleus paraventularular i ka hypothalamus, e alakaʻi ana i ka emiʻana o ka makemake. Ma nā hana supratherapeutic, lorcaserin hydrochlorider ke hana pū nei hoʻi ma nā mea loaʻaʻo 5-HT 2B a me nā mea loaʻaʻo 5-HT 2A.

maika o ka paʻiʻo Lorcaserin Hcl (846589-98-8)

  • ʻO ka momonaʻo Lorcaserin HCL he mea'āpana agonistʻo 5-HT2C i kohoʻia e emi ana kaʻaiʻana ma o ka pūnaewele POMC pūnaewele. ʻO ka loliʻo Lorcaserin HCL:
  • Hoʻopiliʻia ka'opiʻo Lorcaserin HCL me kaʻai a me ka hoʻomehana e mālama i ka momona.
  • Hoʻohanaʻiaʻo Copacaca HCL i kekahi manawa no ka mālamaʻana i ka momona e pili ana i ka maʻi diabetes, high cholesterol, aiʻole ke koko kiʻekiʻe.
  • ʻAʻole hiki i ka Lorcaserin HCL kahe e mālama i kekahi maʻi olakino (e like me ka maʻi o ka maʻi, ka maʻi hīkī, ke koko kiʻekiʻe).

Hōʻoiaʻia ka'ōlelo Malakenaʻo Hcl (846589-98-8) Hana

Hiki i ka'enela Conecaca HCL i ka papa palapala a laweʻiaʻo ia i nā manawa maʻamauʻo 1-2 manawa i ka lā, me kaʻaiʻole. Pono e hoʻohanaʻiaʻo Lorcaserin me kahiʻai ho'ēmi i hoʻemiʻia a me ka papa hana.

ʻO ka lālā i manaʻoʻia o ka lorcaserin hcl ka paukū 10 mg e mālamaʻia e ka waha iʻelua manawa o ka lā. E mālamaʻiaʻo Lorcaserin me ka nānāʻole i kaʻai. Pono e hoʻoneʻeʻiaʻo Lorcaserin hcl i nā maʻi i nele i ka hōʻemiʻana i ka paukū 5% i ka wiki 12 mai hikiʻole i kēia mau maʻi keʻike i ka poho kaumaha kūpono me ka hoʻomauʻana.

Nā hopenaʻaoʻao o ka paʻiʻo Lorcaserin Hcl (846589-98-8)

Ua hoʻohanaʻiaʻo Lorcaserin Hcl e hoʻohanaʻia no ka hoʻomaluʻana i ka hoʻomaluʻana i nā hana kūpono i nā mākua me kahi moʻokūʻauhau kanaka (BMI) o 30 aʻoi aku paha (obese) ma keʻano he mea hoʻonui i kaʻai a me ka hoʻolālā. Ua'āponoʻia no ka hoʻohanaʻiaʻana e nā poʻe mākua me ka BMI o 27 aʻoi aku paha (ʻoi aku ke kaumaha) a he mauʻano o ke kaumaha o ke kaumaha o ke koko (hypertension), aʻo ka cholesterol kiʻekiʻe (dyslipidemia). Eia nō naʻe, he mau hopena hope paha. E like me lalo:

Tnā hopena hopena maʻamau:

  • ʻO Headache,
  • -Ka nui,
  • Ka hoʻouluʻana,
  • -Nausea,
  • ʻO ka waha,
  • -Kauwai, a
  • 'OHypoglycemia (ke koko blood nui).

ʻO nā hopena'ē aʻe o nā hopena maʻamau a piliʻole i pili i ka lorcaserin, penei:

  • ʻO nā pilikia pilikia o ka hoʻopuka pale,
  • -Naʻoʻana i ka nānā a iʻole ka hoʻomanaʻo,
  • Nā pilikia pilikia,
  • -Ke hōʻeuʻeu aiʻole manaʻo no ke olaʻana,
  • -No nā'ōlelo hoʻokūkū,
  • -Ke hoʻokipa naʻauʻole,
  • -E hoʻokuʻu i nā helu pūnaewele koko, a
  • ʻO ka hoʻonuiʻana i ka hormone, prolactin.