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ʻO ka māmā Lorcaserin HCL kalo (846589-98-8)

ʻO Raw Lorcaserin ka lepo a me kaʻeleʻeleʻo 2C (5-HT2C) a me ka lawelaweʻana i nā lāʻau lapaʻau e hoʻolaha ....


Kūlana: I ka Production Production
Mokuna: 25kg / Drum
nona iho: 1380kg / ka mahina

Description

ʻO ka paʻiʻo Lorkerin HCL (846589-98-8) wikiō

ʻO ka māmā Lorkaserin HCL pauka (846589-98-8) Hōʻike

Product Name ʻO Raw Lorcaserin ka lepo
Hawaiian Name ʻO ka Rack Lorcaserin HCL kalo, Lorcaserin
Brand Name KANAWAI
Kōpana Drug XINUM-HT5C mea hoʻonāuki loaʻa
Kāleka CAS 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
hakakino F'Oula C11H15Cl2N
hakakino Wʻewalu 232.15
Monoisotopic Mass 231.058154899
Hoʻolaha Pʻo kaʻaila ʻAʻoheʻikepili i loaʻa
Fkū hou Pʻo kaʻaila ʻAʻoheʻikepili i loaʻa
ʻO ka Halifa-Ola ʻO ka hapalua o ka lorcaserin he mau hola 11 ia. Hoʻopau loaʻia ka lepo i ka urine (92%) a me nā feces (2.2%)
kala like 'ole ʻO ka pauma
Palekana Waiwai Kūmole: 0.0709 mg / mL
pūnaewele Tka mahana -20 ° C.
Apaukū Nero o kaʻenehana receptor 2C (HT2C) no ka pohō kaumaha. Hoʻemiʻia ka meaʻai a hoʻolaha i ka noho'eneʻolu ma waena

ʻO Raw Lorcaserin Hcl kala (846589-98-8) Hōʻike

ʻO kaʻikeʻo Lorkaserin ka waikahu wai ka wai e loaʻa i ka hopena o ka paukū me ka mea like me ka waika hydrochloric. Hoʻohanaʻiaʻo ia he lāʻau lapaʻau. Lorcaserin hydrochloride he agonist receptor 5HT2c i hōʻikeʻia no ka hoʻohanaʻana i nā mākua me ka BMI ≥30, a me nā mea me ka BMI ≥27 a me ka liʻiliʻi hoʻokahiʻano pilikino e like me ka hanu kiʻekiʻe, ka maʻi maʻamau o 2 a dyslipidemia paha. Hoʻokumu i ka leʻaleʻa, a manaʻoʻia e pale i ka pīpī o ka maʻi valvular naʻaupō e pili ana i ka hoʻouluʻana o nā mea hōʻailona 5-HT2B, kahi o ka lolo iʻikeʻia e pāʻani i kaʻai a me kaʻai. Ma ka hoʻonāʻana i kēia mau loea, hiki ke hoʻoemi i kaʻai ma muli o ka hoʻohaʻahaʻaʻana i kaʻai a me ka hoʻonaʻauaoʻana i ke kanaka ma hope o kaʻaiʻana i ka meaʻai ma mua o ka mea maʻamau. uaʻaeʻia i kēia lā e ka FDA ma kahi hoʻoholo koho i ka paukū 2 mau makahiki i kohoʻia.

Hoʻohālikelikeʻiaʻo Lorcaserin hydrochloride ka pauku i mea hoʻokūʻai i ka mea hoʻemiʻia kalolo a me ka hoʻonuiʻana i ka hoʻolālā kino no ka hoʻomaluʻana i ka hana kaumaha i nā mea maʻamau (BMI o 30 kg / m2 aʻoi aʻe) a me ka poʻe keu (BMI o 27 kg / m2 aʻoi aku paha) me ka liʻiliʻi o hoʻokahi kūlana pili pili i ke kaumaha.

Hoʻohanaʻiaʻo Lorcaserin hydrochloride me kaʻai a me ka hana e mālama ai i ka momona. I kekahi manawa hoʻohanaʻia e mālama i ka momona e pili ana i ka maʻi diabetes, ke kiʻekiʻe o ka cholesterol, aiʻole ke koko kiʻekiʻe.

ʻAʻole e hoʻokaeʻia ka maʻi olakinoʻo Lorcaserin hydrochloride (e like me ka maʻi o ka maʻi, ka maʻi hīkī, ke koko kiʻekiʻe). E mālama i kekahi mau lāʻau'ē aʻe a kāu kauka i kauoha ai e mālama i kēia mauʻano.

Lorcaserin Hcl pauki (846589-98-8) Mechanism of Action

ʻOiai keʻikeʻoleʻia ka mechanical like, ua manaʻoʻia ua hoʻokomoʻia ka hoʻouluʻana o nā nūhou 5-HT2C i nā neuxigenic pro-opiomelanocortin neurons i ka piko o ka hypothalamus. ʻO kēia ka hopena o ka hoʻemiʻiaʻana o kaʻai a me ka mālie ma o ka hoʻonāʻana i ka hoʻokuʻuʻana i ka hormone hoʻonani alpha-melanocortin, e hana nei ma nā mīkini melanocortin-4.

Lorcaserin hydrochloride lepo e hana ana ma o ka hoʻonāʻana i ka manaʻo - ma ka hoʻonāʻana i nā nānā i ka lolo no ka serotonin, kahi neurotransmitter e hoʻopiʻi ai i ka hauʻoli a me kaʻoluʻolu. ʻO ka mālamaʻana i kaʻai e hoʻomaluʻia e kahi kikowaena kikowaena, kahi i loko o ka pūnana ventromedial o hypothalamus a me ka haleʻai make ma ka piko hypothalamus. Ke kuhi nei nāʻano kikowaena mai nā kikowaena kiʻekiʻe a me nā puke āpau e pili ana i ka piko nucleus, kahi e noho aiʻeluaʻano neurons e mālama ana i kaʻai. ʻO ka mea mua, nā pūʻulu hoʻoulu o ka meaʻai e hana ana i ka protein a me ke neuropeptide Y. aʻo ka lua, heʻaha hoʻopunipuniʻai i loko o ka cocaine a me ka amphetamine (transca) (CART) a me pro-opiomelanocortin (POMC) neurons. POMC loaʻa nā hōʻailonaʻo 5-HT 2C, i ka wā e hoʻopiliʻia ai ka hormone alpha-melanocyte-stimulating (alfa-MSH) .Paʻani āpau a me nā mea hoʻonāuki e hoʻolālā hou i nā nucleus āpau i ka hypothalamus. ʻO ka pūnaewele hōʻokoʻa he mau mīkini helu 4 melanocyte (MC4R) ka mea e hoʻoneʻe ai i ka makemake i nā kohu lāʻau lorcaserin hydrochloride paukū e hana ana i ka neerons 5-HT 2C maʻamau i nā neurons POMC, aʻo ia ke kumu no ka hoʻokuʻuʻana o alfa MSH. ʻO nā hana'ē aʻe a MSH e hana nei ma MC4R i loko o ka nucleus paraventularular i ka hypothalamus, e alakaʻi ana i ka emiʻana o ka makemake. Ma nā hana supratherapeutic, lorcaserin hydrochlorider ke hana pū nei hoʻi ma nā mea loaʻaʻo 5-HT 2B a me nā mea loaʻaʻo 5-HT 2A.

maika o ka paʻiʻo Lorcaserin Hcl (846589-98-8)

  • ʻO ka momonaʻo Lorcaserin HCL he mea'āpana agonistʻo 5-HT2C i kohoʻia e emi ana kaʻaiʻana ma o ka pūnaewele POMC pūnaewele. ʻO ka loliʻo Lorcaserin HCL:
  • Hoʻopiliʻia ka'opiʻo Lorcaserin HCL me kaʻai a me ka hoʻomehana e mālama i ka momona.
  • Hoʻohanaʻiaʻo Copacaca HCL i kekahi manawa no ka mālamaʻana i ka momona e pili ana i ka maʻi diabetes, high cholesterol, aiʻole ke koko kiʻekiʻe.
  • ʻAʻole hiki i ka Lorcaserin HCL kahe e mālama i kekahi maʻi olakino (e like me ka maʻi o ka maʻi, ka maʻi hīkī, ke koko kiʻekiʻe).

Hōʻoiaʻia ka'ōlelo Malakenaʻo Hcl (846589-98-8) Hana

Hiki i ka'enela Conecaca HCL i ka papa palapala a laweʻiaʻo ia i nā manawa maʻamauʻo 1-2 manawa i ka lā, me kaʻaiʻole. Pono e hoʻohanaʻiaʻo Lorcaserin me kahiʻai ho'ēmi i hoʻemiʻia a me ka papa hana.

ʻO ka lālā i manaʻoʻia o ka lorcaserin hcl ka paukū 10 mg e mālamaʻia e ka waha iʻelua manawa o ka lā. E mālamaʻiaʻo Lorcaserin me ka nānāʻole i kaʻai. Pono e hoʻoneʻeʻiaʻo Lorcaserin hcl i nā maʻi i nele i ka hōʻemiʻana i ka paukū 5% i ka wiki 12 mai hikiʻole i kēia mau maʻi keʻike i ka poho kaumaha kūpono me ka hoʻomauʻana.

Nā hopenaʻaoʻao o ka paʻiʻo Lorcaserin Hcl (846589-98-8)

Ua hoʻohanaʻiaʻo Lorcaserin Hcl e hoʻohanaʻia no ka hoʻomaluʻana i ka hoʻomaluʻana i nā hana kūpono i nā mākua me kahi moʻokūʻauhau kanaka (BMI) o 30 aʻoi aku paha (obese) ma keʻano he mea hoʻonui i kaʻai a me ka hoʻolālā. Ua'āponoʻia no ka hoʻohanaʻiaʻana e nā poʻe mākua me ka BMI o 27 aʻoi aku paha (ʻoi aku ke kaumaha) a he mauʻano o ke kaumaha o ke kaumaha o ke koko (hypertension), aʻo ka cholesterol kiʻekiʻe (dyslipidemia). Eia nō naʻe, he mau hopena hope paha. E like me lalo:

Tnā hopena hopena maʻamau:

  • ʻO Headache,
  • -Ka nui,
  • Ka hoʻouluʻana,
  • -Nausea,
  • ʻO ka waha,
  • -Kauwai, a
  • 'OHypoglycemia (ke koko blood nui).

ʻO nā hopena'ē aʻe o nā hopena maʻamau a piliʻole i pili i ka lorcaserin, penei:

  • ʻO nā pilikia pilikia o ka hoʻopuka pale,
  • -Naʻoʻana i ka nānā a iʻole ka hoʻomanaʻo,
  • Nā pilikia pilikia,
  • -Ke hōʻeuʻeu aiʻole manaʻo no ke olaʻana,
  • -No nā'ōlelo hoʻokūkū,
  • -Ke hoʻokipa naʻauʻole,
  • -E hoʻokuʻu i nā helu pūnaewele koko, a
  • ʻO ka hoʻonuiʻana i ka hormone, prolactin.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.


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Nāʻike & nā hua'ōlelo huahana

Uaʻaeʻo FDA iā Lorcaserin HCL no keʻano o kaʻele

E hoʻomaopopo '

  1. ʻO Bohula,ʻo'Erin A.,ʻo Wiviott,ʻo Stephen D., McGuire, Darren K., Inzucchi, Silvio E., et al .: Hauka o ka Cardiovascular o Lorcaserin ma ka Poʻopoʻapo a iʻole nā ​​Kiʻi Poʻe, ʻO ka New England Journal of Medicine, 2018
  2. Nā lawelaweʻai meaʻai a me nā lāʻauʻai lāʻau, nā Kaulana Paʻa Long-Term Weight Control, Online, Hoʻopukaʻia 17 Iulai 2012
  3. ʻO Ashley Gustafson, Cammile King, Jose AR, National Center for Biotechnology Information, PMC Articles, MediMedia, USA Lorcaserin (Belviq), Online, September 2013

ʻO Shangke Chemical he polokalamu kelehana kiʻekiʻe e kū nei i nā mea hana hana hoʻopihamaha hana (APIs). No ka mālamaʻana i ka maikaʻi i ka manawa o ka hanaʻana, kahi nui o nāʻoihana akamai, nā mea hana papa hana mua a me nā hale liʻiliʻi i nā kumu nui.

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