Anandamide (AEA) (94421-68-8)

March 15, 2020
SKU: 77472-70-9
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ʻO Anandamide, i ʻike ʻia ʻo N-arachidonoylethanolamine (AEA), he ʻano momona o ka momona me ka neurotransmitter momona mai ...


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

He wikiō ʻo Anandamide (AEA) (94421-68-8)

Anandamide (AEA) (94421-68-8) Snāʻike

Product Name Anandamide (AEA)
Hawaiian Name Arachidonylethanolamide; N-Arachidonoylethanolamine; Anandamide (20.4, n-6);

N-Arachidonoyl-2-hydroxyethylamide; Arachidonoyl ethanolamide; AEA;

Kāleka CAS 94421-68-8
InChIKey LGEQQWMQCRIYKG-DOFZRALJSA-N
SMILE CCCCCC = CCC = CCC = CCC = CCCCC (= O) NCCO
Ka Lā Molecular C22H37NO2
Molecular Weight 347.53
Monoisotopic Mass 347.282429 g / mole
Point Hoʻolālā N / A
ʻO Boiling Point 522.3 ± 50.0 ° C (Manaʻo ʻia)
nuʻa 0.92 g / mL i 25 ° C (lī.)
kala like 'ole 'ōlena'ōmaʻomaʻo
Shoʻoweliweli temp -20 ° C
Palekana ethanol: hoʻoheheʻe
noi Hoʻohana ʻia ia no ka hoʻomanaʻo, ka hoʻowalewale, nā hoʻoheheʻe ʻana, nā hana hoʻowalī, nā ʻeha ʻana, ka hoʻoweliweli ʻana a me ka momona.

He aha iā Anandamide (AEA)?

ʻO Anandamide, i ʻike ʻia ʻo N-arachidonoylethanolamine (AEA), he ʻano momona o ka hoʻōla momona mai loko mai o ka eʻe-oxidative metabolism o ka eicosatetraenoic acid (arachidonic acid. He ʻano like kona like me ka tetrahydrocannabinol, kahi kumupaʻa ikaika o nā cannabis. hoʻokaʻawale ʻia e ka momona acid amide hydrolase (FAAH) e hoʻohuli ana i ka anandamide i loko o ka ethanolamine a me ka waikawa arachidonic, Ma hope, ua hoʻoneʻe ʻia ʻo Anandamide i ka neuron e ka hopena hoʻokaʻeha i waena o ka waikona arachidonic a me ka ethanolamine ma lalo o ka hoʻoponopono ʻana o ka calcium a me ka cyclic monophosphate adenosidase. ʻO ia kahi o kahi pūʻulu o nā mea ikaika e pili ana i ka physiologically (Prostamides) e hana nei i nā hana he nui i ke ʻano kino, ʻoi aku ka makemake, ka hoʻomanaʻo, ka ʻeha, ke kaumaha, a me ka momona.

Aia ka anandamide i nā meaola he nui, e like me ka urchin roe kai, nāole ʻawaʻawa a me nā kiʻi ahewa ʻia, ʻokoʻa, akā liʻiliʻi kāna helu. Eia kekahi, loaʻa kekahi noiʻi ʻo Anandamide a me nā mea ʻelua (N-oleoylethanolamine a me N-Linoleylethanolamine) i loko o kahi polokaʻeleʻele. Ke ola nei ʻo Anandamide i kekahi mauʻu hānai ʻia, (ʻaila keʻokeʻo), Alika (maʻa mau, hoʻohana ʻole a hoʻohana ʻole ka inu ʻawa), Kaʻaila hoʻoliʻiliʻi, Trans fats, Nā mea kīpī i loko o ka aila aila a me nā meaʻai ʻole-organik e loaʻa nā mea pesticides etc.

Ma keʻano he lula o ka pūnaehana endocannabinoid (ECS), ʻo Anandamide ka heluʻana i ka hoʻoponopono o ka homeostasis pū kekahi me kahi papa o ka cannabis-like chemical 2-AG a me nā mea komo endogenous cannabinoid ma loko o ke kino. Aia kēia ʻōnaehana I nā vertebrates āpau. He hana nui ʻo Anandamide i ka hoʻoponopono ʻana i ka ʻai hānai a me nā ʻano hoʻoliʻi neurogen a me ka leʻaleʻa, e mālama ana i ko mākou kino a me ka noʻonoʻo. Ua ʻike nā noiʻi e pili ana i kā mākou mau manaʻo, hauʻoli, hopohopo, hopohopo, a hiki ke kūpaʻa i ke kaumaha ua hoʻoponopono ʻia lākou e ka ʻōnaehana endocannabinoid, a me nā maʻi like ʻole mai ka schizophrenia i ke kaumaha ua hele pū ʻia e nā pae anandamide abnormal.

ʻO Anandamide, e like me THC, he ʻāpana agonist o CB1R. Hiki iā ia ke hoʻonui i ka hoʻonui ʻia e ka "piha" i ka hoʻonohonoho ʻana o ka lolo. He mea kūpono ia e ʻike ʻia nei kēia mau hopena āpau o Anandamide e hoʻoikaika ʻia e ka pharmacologically inhibiting its metabolabegregradation. Loaʻa ka loaʻa ʻana o Anandamide e alakaʻi i kahi ʻohana hou i ka lāʻau lapaʻau hou.

Loaʻa maikaʻi ʻo Anandamide (AEA)

ʻO Anandamide, i kapa ʻia kekahi ʻ moleclule bliss ", he mea hoʻomaikaʻi i ka ʻoluʻolu, neurotransmitter a me endocannabinoid, ka nui o nā pono olakino a me ka noʻonoʻo.

Hoʻolālā ʻo Anandamide i ka wikiwiki o ka hoʻokumu ʻana o nā pūpū maʻi. I ka makahiki 1998, ʻike kahi hui o nā kānaka ʻepekema Italia hiki i ke anandamide hiki ke hoʻolaha i ka neurogenesis a hana i nā ʻāpana neʻe hou, me ka hoʻomaʻamaʻa maikaʻi ʻana i ka hoʻokumu ʻana / hoʻonui i nā waiwai o nā ʻōpū maʻi umauma.

Loaʻa i ka hiki i Anandamide e hoʻolaha i ka neurogenesis (ke ʻano o nā neurons hou) e hana i ka hana o ka pale ʻana i ka ʻai e ʻai ana a me ke kuhi ʻana i ka hoʻowalewale a me ka leʻaleʻa i nā kiʻi. E kōkua kēia i ka hōʻoluʻolu i nā hōʻailona o ke kaumaha a me ke kaumaha. Ua ʻike ʻia kahi haʻawina i 2015 o nā kānaka a me nā mea ʻiʻo nā kiʻekiʻe kiʻekiʻe o ka anandamide e hiki ke hoʻoikaika i ka hoʻomaikaʻi ʻana i ka naʻau a me ka hoʻohaʻahaʻa makaʻu.

Eia kekahi, hiki i ka anandamide ke hoʻopaʻa iā CB1 a me CB2 receptors e hoʻopilikia nui i nā ʻano e pili ana i ka physiological, e hōʻike ana i nā pono maikaʻi ma o ke hoʻomanaʻo, ka hoʻoulu ʻana, ka ʻōnaehana cognitive, ka pale ʻana, ʻeha hōʻeha, ka hoʻowalewale i ka makemake a me ka momona.

Pehea e hoʻonui ai i ka anandamide(AEA) pae ma ke kino kanaka?

No ka mea he kuleanalay ka anandamide ma ke ʻano he neurotransmitter, mea a vasodilator a me nā mea hoʻoliʻelima koko sula, a me ka pōmaikaʻi a me ka noʻonoʻo i hōʻike ʻia, makemake paha ʻoe e hoʻonui i ke kiʻekiʻe o ka anandamide i kou kino. Eia kekahi mau ala e hoʻoliʻiliʻi hou ai i nā pae anandamide i loko o ke kino kanaka:

- Kahuaʻailoa

Ua ʻike ʻia ka noiʻi ʻana ma hope o 30 mau holo o ka holo, ua hoʻonui ʻia ka ʻōʻili o ka anandamide (AEA) o nā kāne a me nā ʻīlio. No laila inā makemake ʻoe e loaʻa ka pōmaikaʻi nui loa, e hana pinepine i kekahi aerobic hoʻomaʻamaʻa pinepine.

- Ka ʻai i kāʻeleʻeleʻele

ʻOi aku ka poliʻeleʻele he hapa nui o ka theobromine i loko o ka sime olakino, a kōkua ke theobromine i ka hoʻonui ʻana i ka hana anandamide i loko o ka lolo a hoʻolōʻihi i kona wā hōʻoki ʻia.

- Kai i nā ʻeleʻele ʻeleʻele

ʻ trleʻele ʻeleʻele (ʻeleʻele ʻeleʻele) nona kahi anandamide. ʻOiai hiki ʻole i ka mōʻī ke hoʻohana pono i ka anandamide i kekahi ʻano, ke noiʻi nei nā mea noiʻi e hoʻohana ʻia ana no nā holoholona e ʻai iā ia a hana pū i kāna mau spora.

- Loaʻa i ka manaʻo

Hōʻike ka noiʻi ʻana i ka wā i noho ai kekahi kanaka (i kapa ʻia ʻo "kahe" a i ʻole "ma kahi ʻāina,") ke ʻano kiʻekiʻe, ka hana a me ka neʻe ʻana, ʻaʻole wale ʻoe e lilo i ka hana a i ʻole nā ​​hana hou i loko o kou lolo a hoʻokuʻu pū nō ia. ka helu nui o nā mea kemika, e like me serotonin, dopamine, endorphin a me anandamide.

Eia kekahi, kaʻaila, coriander a me ka celery hiki ke kōkua i ka hoʻonui ʻana i ka hana o ka anandamide.

Reference:

  • Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 Mei 2001). "Anandamide a me ka meaʻai: ʻO ka hoʻopili o ka arachidonate kaʻai a me ka docosahexaenoate e alakaʻi i ka nui o ka lolo o nā lolo N-acylethanolamines ma nā piglets". Nā hana i loko o ka National Academy of Science. 98 (11): 6402– Baibala: 2001PNAS ... 98.6402B. doi: 10.1073 / pnas.101119098. PMC 33480. PMID 11353819.
  • El-Talatini MR, Taylor AH, Konje JC (ʻApelila 2010). "ʻO ka pilina ma waena o nā pae plasma o ka endocannabinoid, anandamide, nā steroid sex, a me nā gonadotrophins i ka manawa o ke kāne." Kukulu. ʻŌkoi. 93 (6): 1989– doi: 10.1016 / j.fertnstert.2008.12.033. PMID 19200965.
  • Habib, Abdella M .; Okorokov, Andrei L .; Hill, Matthew N .; Bras, Jose T .; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J .; van Drimmelen, Marie; Morena, Maria (Malaki 2019). "Microdeletion i kahi pseudogene i hoʻomaopopo ʻia i ka mea maʻi me nā kiʻekiʻe o ka anandamide kiʻekiʻe a me nā ʻeha ʻeha." Ka Pelekane Pelekane o Anesthesia. 123: e249– doi: 10.1016 / j.bja.2019.02.019. PMID 30929760.
  • Mahler SV, Smith KS, Berridge KC (Nowemapa 2007). "Endocannabinoid honu hedonic no ka leʻaleʻa sensory: anandamide ma ka nucleus accumbens hoʻonaninani i ka 'makemake' ʻana i kahi uku momona". Neuropsychopharmacology. 32 (11): 2267– doi: 10.1038 / sj.npp.1301376. PMID 17406653.
  • Mechoulam R, Fride E (1995). "Ke ala ʻole i hele ʻole ai i nā polima cannabinoid kaila, ʻo nā anandamides". I Pertwee RG (ed.). Nā ʻāpana Cannabinoid. Boston: Kumupaʻa ʻiclelo. pp 233– ISBN 978-0-12-551460-6.
  • ʻO Mallet PE, ʻo Beninger RJ (1996). "ʻO ka receptor cannabinoid receptor agonist anandamide e hoʻopiʻi i ka hoʻomanaʻo i nā kiore". ʻAmaʻaleʻa ʻAmelika. 7 (3): 276– doi: 10.1097 / 00008877-199605000-00008.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.