ʻIkepili kemika o ka pauka 5a-hydroxy laxogenin
| Product Name | 5a-hydroxy laxogenin pauka |
| 'O Synonyms | 5alpha-Hydroxy laxogenin; 5-alpha-Hydroxy-laxogenin; 5 alpha hydroxy laxogenin; 5-alpha hydroxy laxogenin; 5-alpha-hydroxy laxogenin; 5a hydroxy laxogenin; 5a-hydroxy Laxogenin |
| Mea Maʻemaʻe | > = 99% |
| Kāleka CAS | 56786-63-1 |
| Kōpana Drug | he analogue spirostanic o ka brassinosteroid |
| InChI Key | HCRGPOQBVFMZFY-PPCFKNSFSA-N |
| SMILE | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC(=O)C6(C5(CCC(C6)O)C)O)C)C)OC1 |
| Ka Lā Molecular | C27H42O5 |
| Molecular Weight | 446.6 |
| Monoisotopic Mass | 446.30322444 |
| Point Hoʻolālā | 247-250 ° C |
| ʻO Boiling Point | 578.4 ± 50.0 ° C (Manaʻo ʻia) |
| Ehapalua ola | 6-8 hola |
| kala like 'ole | ʻO ka pauma |
| Palekana | DMF: 15mg/mL; DMSO: 10mg/mL |
| Shoʻoweliweli temp | Hoʻopaʻa ʻia i loko o kahi maloʻo, lumi wela |
| noi | Pākuʻi; kino kino; loaa mussule |
Ke nānā pinepine nei nā bodybuilders a me nā mea pāʻani i nā ala e hoʻonui ai i ka nui o ka ʻiʻo lean me ka hoʻonui ʻole i ka momona o ke kino. ʻO kekahi o nā ala maʻalahi e hoʻokō ai i kēia, ʻo ia ka hoʻohana ʻana i nā steroids anabolic, akā ʻo ka hoʻohana lōʻihi ʻana o kēia mau steroid i kekahi mau hopena ʻaoʻao e hiki ke hoʻopau i nā mea he nui.
Ua loaʻa i nā haʻawina hou kahi mea kanu i manaʻoʻiʻo ʻia e ka poʻe ʻepekema e loaʻa nā hopena like me nā steroid anabolic, akā naʻe, me ka ʻole o nā hopena ʻino o ka steroid.
ʻIke ʻia ka pūhui ʻo 5a hydroxy laxogenin maʻamau a i ʻole ma kona inoa ʻepekema, 5-alpha-hydroxy laxogenin. ʻO 5a hydroxy laxogenin pauka ke kūʻai ʻia nei e ka hapa nui o 5a hydroxy laxogenin pauku mea hoʻolako ma ke ʻano he mea hoʻohui bodybuilding ma muli o nā pono he nui o ka huahana.
He aha ka 5a-hydroxy laxogenin?
ʻO 5a-hydroxy laxogenin, he mea ia o ka laxogenin, he kemika i loaʻa ma ke ʻano, i nā mea kanu. ʻO Laxogenin a i ʻole 3beta-hydroxy-25D, 5alpha-spirostan-6-one, he mea hoʻokele anabolic i hoʻokumu ʻia i ka mea kanu i lilo i mea kaulana i waena o nā mea pāʻani a me nā bodybuilders no kāna mau waiwai hoʻonui i ka nui o ka ʻiʻo.
ʻO ke kumu ma hope o ka ulu nui ʻana o Laxogenins ʻo kā lākou kuleana i nā mea kanu. He mau hormones mea kanu lākou, i ʻike ʻia hoʻi he brassinosteroids i hoʻonohonoho ʻia a me ka hana, e like me ka holoholona a me nā hormone steroid kanaka. Ma muli o kēia, ke hoʻololi nei lākou i nā steroid anabolic.
Hiki ke loaʻa nā Laxogenins mai nā aniani Kina a i ʻole nā kumu lalo o ka mea kanu ʻAsia, Smilax sieboldii. ʻO Laxogenins, i ka hapa nui o nā mea hoʻopihapiha i hana ʻia a kūʻai ʻia e ka mea hana 5a-hydroxy laxogenin pauka, loaʻa maoli mai kekahi mea kanu steroid diosgenin. Hoʻohana pū ʻia kēia mea kanu steorid i ka synthesis o nā hormones synthetic ʻē aʻe e like me ka progesterone, i hoʻohana nui ʻia i nā lāʻau hoʻomalu hānau.
ʻO ka hapa nui o nā brands i loaʻa iā 5a hydroxy laxogenin pauka no ke kūʻai aku, ma ke ʻano he mea hoʻohui, aia kēia derivative o laxogenin, i loaʻa mai diosgenin, ma kahi o ka laxogenin maoli. Eia naʻe, ʻaʻole ia he mea hopohopo nui no ka mea ua like nā pōmaikaʻi 5-alpha-hydroxy-laxogenin me ka laxogenin.
He prohormone anei ka 5-alpha-hydroxy laxogenin?
Nui nā mea hana 5a hydroxy laxogenin a me 5a hydroxy laxogenin pauka mea hoʻolako i ka pūhui ma ke ʻano he prohormone. ʻO ka prohormone kahi mea hoʻohui i hoʻokahi manawa i loko o ke kino, e hoʻololi ʻia e lilo i hormone kikoʻī.
ʻO kahi hiʻohiʻona kūpono he androgens, e hana ana ma ke ʻano he prohormones a i hoʻokahi manawa i hoʻopili ʻia a hoʻololi ʻia i ka hormone, testosterone. ʻO 5a hydroxy laxogenin pauka ʻaʻole ia he pre-hormone no ka mea ʻaʻole ia e hoʻololi i kahi hormone, akā loaʻa nā pōmaikaʻi like me ka hormone steroid.
He steroid anei ka 5-alpha-hydroxy laxogenin?
ʻO ka 5a hydroxy laxogenin he mea hoʻokele mea kanu e kaʻana like ana me nā hormone steroid holoholona. ʻO ia ka mea like loa me nā hormones i loko o ke kino kanaka i loaʻa mai ka cholesterol. He mea nui e kuhikuhi i ka 5a hydroxy laxogenin pauka he hana hoʻonui i ka ulu i nā mea kanu akā ʻoi aku ka paʻakikī o nā hopena o ia mea ma ke kino o ke kanaka.
Ma mua o ka hele ʻana i loko o ka membrane a hoʻoulu i ka hoʻololi ʻana iā ia iho, hoʻopaʻa ʻia kēia pūhui i ka mea hoʻokipa a hoʻāla i kahi kaulahao hōʻailona, e hoʻopau me ka piʻi nui ʻana i nā hiki ke kūkulu i nā ʻiʻo o ke kino.
ʻO ka protein kiko'ī i ho'ālaʻia e ka 5a hydroxy laxogenin powder he protein kinase B a iʻole AKT 1. Uaʻike nuiʻia kēia pūmua no kona hiki ke hoʻonui i ka hanaʻana o nāʻiʻo i loko o ke kino kanaka akā no ka paleʻana i ka haʻihaʻi o kaʻiʻo.
Hoʻohaʻahaʻa ʻia nā protein ʻiʻo i ka wā o ka hoʻomaʻamaʻa nui akā ua manaʻo ʻia ʻo nā pono like ʻole 5-alpha-hydroxy laxogenin e pili ana i ka pale ʻana i ka hōʻemi ʻana o ka protein a me ka haki ʻana i ka wā hana.
ʻO kekahi hana'ē aʻe e hana ai ka 5a hydroxy laxogenin pauka i nā pono e hoʻopiʻi i nā bodybuilders a me nā mea pāʻani ma ke kāohiʻana i ka hakiʻana o kahi enzyme nui,ʻo ia hoʻi, cAMP.
ʻO ka hoʻonui ʻana i ka nui o kēia enzyme i loko o ke kino ma ke kāohi ʻana i kona haki ʻana a laila ka hopena i ka nui o ka haki ʻana o ka momona i ke kino. I ka manawa like, ʻo ka hoʻonui ʻana i kēia enzyme ka hopena i kahi pane hakakā-a-lele.
Ma keʻano holoʻokoʻa, ke kūʻai aku nei nā mea hoʻolako pauka hydroxy laxogenin 5a i kahi huahana e hoʻonui ai i ka nui o ka ʻiʻo, hoʻemi i ka haʻihaʻi protein, a hoʻonui i ka haki ʻana o ka momona, i ka manawa like. Manaʻo ʻia kēia mau hopena e like me kēia nā hopena i ʻike pinepine ʻia i nā ʻano like ʻole o 5a hydroxy powder study i hana ʻia ma nā ʻano holoholona a i ʻole in vitro, i loko o kahi lab. Eia naʻe,ʻaʻole hiki keʻikeʻia kēia mau hopena i loko o ke kino o ke kanaka ke laweʻia nā mea hoʻopihapiha i kūʻaiʻia e nā mea hana likeʻole 5a hydroxy laxogenin pauka.
Ua like ka 5a-hydroxy laxogenin me Laxogenin: 5a hydroxy laxogenin vs laxogenin
Loaʻa ka 5a-hydroxy laxogenin mai ka hormone mea kanu, laxogenin. Loaʻa iā lākou nā pōmaikaʻi like, e like me nā ʻāpana noiʻi like ʻole i hana ʻia ma nā ʻano holoholona. Akā naʻe, ʻaʻole like lākou.
He aha ka 5-alpha-hydroxy laxogenin?
ʻO ka 5-alpha hydroxy laxogenin ka mea like loa me nā hormones sex i synthesized mai ka cholesterol i loko o ke kino kanaka. ʻO kēia mau hormones wahine i ʻike maoli ʻia i loko o ke kino o ke kanaka ke hana nei i nā mea hoʻokipa nuklea, aʻo ka 5a hydroxy laxogenin e pili ana i kahi mea loaʻa kelepona, ma ka ʻili o ke kelepona.
Nui nā hui i loaʻa iā 5a hydroxy laxogenin pauka no ke kūʻai pinepine ʻana i kēia mea hoʻohui me ka hoʻolaha hoʻolaha e loaʻa iā ia a hiki i ka 200 pakeneka mana a hiki ke hoʻomaikaʻi maikaʻi i ka leo ʻiʻo i waena o nā mea pāʻani. ʻO kēia mau ʻōlelo i hana ʻia e nā mea hana like ʻole he hopena ia o nā haʻawina i hana ʻia me ke kumu o ka loiloi ʻana i nā waiwai hoʻonui i ka muscle-mass o laxogenins.
Ua ʻike ʻia kahi noiʻi Lūkini hou e pili ana i nā ʻano holoholona i loaʻa nā pūhui thermogenic mai ka hui like o nā hormones mea kanu e like me laxogenin, me nā hopena like me ka laxogenin. Wahi a kēia haʻawina, ua hiki i kēia mau brassinosteroid derivatives ke hoʻonui i ka ʻiʻo protein o ke ake, naʻau, nā puʻupaʻa, a me nā ʻiʻo wāwae. Eia kekahi, ua ʻike nā mea noiʻi ʻaʻole i hoʻopuka kēia mau derivatives i kēia mau pono ma o ka hoʻopili ʻana a i ʻole ka hoʻohālikelike ʻana i ka hopena o nā hormones sex i ke kino o ke kanaka.
ʻO kekahi noiʻi noiʻi ʻē aʻe i hana ʻia ma nā ʻano holoholona a hoʻohana i nā hormones no ka papa like o nā hormones mea kanu e like me ka laxogenin i hiki ke hoʻopili i nā hopena like me ka noiʻi Lūkini. Ua mālama ʻia nā ʻāpana noiʻi ʻē aʻe e hōʻoia i ka pono o kēia mau hopena a ua ʻike ʻia nā hopena e maʻalahi e hoʻopili hou ʻia, no laila, e hōʻoiaʻiʻo ana i ko lākou ikaika a me ka pono.
He mea nui e kuhikuhi i ka nui o nā mea hoʻohana o 5a hydroxy laxogenin pauka e koi ana e ʻike i nā hopena i hoʻolaha ʻia e nā mea kūʻai aku, ua paʻakikī ka loaʻa ʻana o nā hōʻike ʻepekema paʻa e kākoʻo i kā lākou hoʻohana. Hana ʻia ka hapa nui o nā haʻawina ma nā ʻano holoholona a hoʻohana i nā pūhui i pili i ka papa brassinosteroid o nā hormones a i ʻole kekahi hormone mea kanu like, phytoecdysteroids. Ua like nā Laxogenins me kēia mau hormones a ʻo 5a hydroxy laxogenin he mea ia o nā laxogenins, akā ʻaʻole ia e hōʻoiaʻiʻo i nā pono like i ʻike ʻia me nā hormones ʻē aʻe.
Hoʻokahi haʻawina i hana ʻia me ka laxogenin kūlohelohe a me ka synthetic i loko o kahi hoʻonohonoho hoʻokolohua i ʻike ʻia e hiki i kēia pauka ke hōʻemi nui i ke kaumaha oxidative i ke kino. Ua hana ʻia ka hoʻemi ʻana i ke koʻikoʻi oxidative e nā laxogenins ma ka hōʻemi ʻana i nā radical manuahi, kahi ʻano mea ʻino i loko o ke kino e hiki ke komo i nā hopena kemika like ʻole a hōʻeha nui i ke kino. Hiki i kēia ho'ēmiʻana i nā radical free a me ke koʻikoʻi oxidative ke wehewehe pehea e hiki ai i ka 5a hydroxy laxogenin pauka ke hoʻomaikaʻi i ka hoʻihoʻi ʻana i ka ʻiʻo, post-workout. Eia nō naʻe, pono e hana ʻia kēia haʻawina ma nā ʻano holoholona a me nā kumuhana kanaka ma mua o ka manaʻo nui ʻana o nā hopena o ka noiʻi.
ʻO nā haʻawina āpau i ʻōlelo ʻia ma luna nei i hana ʻia me ke kumu e ʻike ai inā hiki i nā laxogenins ke hoʻonui i ka nui o ka ʻiʻo a me ke kani. Eia naʻe, ʻo ka hoʻohana wale ʻana o 5 alpha-hydroxy laxogenin ʻaʻole ia he bodybuilding a ʻo ia ka mea a kekahi o nā ʻāpana noiʻi ʻē aʻe i manaʻo ai e hōʻoia.
I loko o ʻelua mau haʻawina ʻokoʻa, ʻo ka hoʻohana ʻana i ka pauka 5-alpha-hydroxy laxogenin i ka poʻe maʻi maʻi maʻi colon i hōʻemi nui i ka nui o ka maʻi kanesa. Pēlā nō, ua ʻike ʻia ka hoʻomohala ʻana o ka maʻi kanesa me ka hoʻohana ʻana i ka pauka 5a hydroxy laxogenin i nā ʻano holoholona. ʻOiai ʻaʻole hiki i kēia mau haʻawina ke hāʻawi i nā hōʻike paʻa i koi ʻia no nā mea hoʻohui a i ʻole nā lāʻau lapaʻau e hoʻokomo ʻia i loko o ka protocol lapaʻau, he pae lākou i ke ala kūpono.
I ka manawa hea e lawe ai i ka 5-alpha-hydroxy laxogenin?
Hoʻomaka ka 5-alpha-hydroxy laxogenin powder dosage mai 25 mg, a ʻo ia ka nui o ka lawe ʻana i kēlā me kēia manawa. Eia nō naʻe, hiki i ka 6, a me ka liʻiliʻi loa o 3, hiki ke lawe ʻia i ka lā a pau, e hana ana i ke ʻano o ka hoʻohui, 150 mg i kēlā me kēia lā. Manaʻo ʻia hoʻi e lawe i ka pauka hoʻohui me ka meaʻai e hoʻonui i ka absorption i ka ʻōpū.
Hiki ke lawe ʻia ka 5a hydroxy laxogenin pauka no ka 3 mahina a hiki i ka 4 mahina i ka manawa no ka mea ʻo ia ka manawa e ʻike ʻia ai nā hopena. Hiki ke lawe mau ʻia no ka lōʻihi ma mua o kēlā inā pono a makemake paha. No ka mea, ʻaʻohe hopena o ka hui kūlohelohe i ka pae o ka hormone o ke kino, ʻaʻole pono e kaupalena ʻia i kahi manawa pōkole.
ʻAʻole ʻike maikaʻi ʻia nā hopena ʻaoʻao 5-alpha-hydroxy laxogenin no ka mea ʻo ka hapa nui o nā haʻawina i hana ʻia e loiloi i ka pono o ka hoʻohui ʻana ʻaʻole i hana ʻia ma nā kumuhana kanaka. Hana ʻia lākou ma nā ʻano holoholona a ʻaʻole hiki ke hoʻoholo i nā pono a me nā hopena ʻaoʻao mai kēia mau haʻawina. Eia naʻe, ʻaʻole i hōʻike ka poʻe hoʻohana i nā mea hoʻohui i nā mea ʻawaʻawa a i ʻole nā hopena ʻino, i alakaʻi ai i ka manaʻoʻiʻo ʻaʻohe hopena ʻaoʻao.
ʻO wai ka mea e noʻonoʻo e hoʻohana iā ia?
ʻO nā bodybuilders, nā mea pāʻani, a me nā mea ʻē aʻe e makemake e hoʻonui i ka leo a me ka nui o ka ʻiʻo i ka wā e hoʻemi ana i ka momona o ke kino e noʻonoʻo e hoʻohana i ka 5a hydroxy laxogenin pauka.
He kānāwai anei ka 5-alpha-hydroxy laxogenin?
Manaʻo ʻia ʻo 5a hydroxy laxogenin he mea ʻae ʻole i hoʻolaha ʻia e ka Food and Drug Association a i ʻole FDA ma ʻAmelika Hui Pū ʻIa. Ua nānā ʻia ka mea hoʻohui e ka USADA no ka manawa lōʻihi no ka mea ua ʻike lākou aia ia i loko o nā huahana a i ʻole nā mea hoʻohui i loaʻa pū kekahi mau mea hoʻoikaika hana. ʻO kahi kumu'ē aʻe o ka hopohopo me ka 5a hydroxy laxogenin paukaʻo ia ka mea i hoʻolahaʻia ma keʻano he steroid anabolic kūlohelohe. Ua hāpai ʻo FDA a me USADA i nā nīnau e pili ana i ke kumu maoli o 5a hydroxy laxogenin e like me ka mea kanu maoli e hāʻawi ai i ka hormone laxogenin wale nō. ʻAʻole i wehewehe ʻia pehea e loaʻa ai ka hydroxy laxogenin mai ka laxogenin.
Ua hana ʻo USADA i kahi kānana kikoʻī o nā pauka 5a hydroxy laxogenin like ʻole no ke kūʻai aku a loaʻa i ka hapalua o ia mau mea hoʻohui e hoʻopili ʻia me nā mea doping. I ka ho'āʻo e hoʻopakele 'âlapa a me bodybuilder mai accidental doping ma ka hoʻohana 'ana i keia 'mea kanu maoli mea steroid', USADA ua noi aku ia lakou e makaʻala no kekahi mea hoʻopihapiha i loaʻa laxogenin i hiki ke oleloia ma ka papa inoa o:
- UNII-HT7W184YG4
- HT7W184YG4
- ʻO SCHEMBL4027062
- ZINC70691911
- (25r) -3beta-hydroxy-5alpha-spirostan-6-one
- Q272800835
- alpha-hydroxy-laxogenin
- 5a-hydroxy-laxogenin
- 5-laxogenin
- (25R)-3beta,5alpha-dihydroxyspirostan-6-hoʻokahi
- 25-R-spirostan-5a-diol-6-kahi-3-kahi
- 25R spirostan-5a-diol-6-one-3-one decanoate
- 25R spirostan-5a-diol-6-one-3-one undecanoate
Ke kānalua nei hoʻi ʻo USADA ʻo ka huaʻōlelo laxogenin ma kahi papa inoa mea hoʻohui ke lilo i ʻike huna no ka poʻe e ʻimi nei i nā mea hoʻohui doping, ʻo ia hoʻi ʻaʻohe laxogenin maoli a i ʻole 5a hydroxy laxogenin i loko o ka waihona.
ʻO ka FDA, e like me USADA, he ʻokoʻa nā laxogenins i nā meaʻai meaʻai no ka mea ʻaʻole lawa ka ʻike e pili ana i kona hoʻohana ʻana, palekana, a me ka ikaika. Me ka noiʻi hou aʻe, hiki ke ʻae ʻia ka mea hoʻohui e like me ka mea hoʻohui hoʻoikaika ikaika.
Loaʻa kēia hiki no ka mea, ʻoiai ʻo ka USADA e haʻi ana i nā laxogenins a me kā lākou derivatives ma ke ʻano he mea ʻae ʻole, ʻaʻole i pāpā ka World Anti-Doping Authority i kā lākou hoʻohana ʻana i waena o nā mea pāʻani. ʻAʻole kūpono ka 5a hydroxy laxogenin i nā koina no ka helu ʻia ʻana ma ke ʻano he mea doping.
Eia kekahi, ʻaʻole maikaʻi ka hoʻāʻo lāʻau 5a hydroxy laxogenin i ka wā e nānā ai i nā mea doping inā ʻaʻole i hoʻopili ʻia ka pauda a i ʻole nā mea ʻē aʻe i pāpā ʻia.
Nānā 5-alpha-hydroxy laxogenin
ʻO ka hapa nui o nā mea hoʻohana o 5-alpha-hydroxy laxogenin pauka e hoʻohiki iā ia a koi e ʻike i nā hopena i hoʻolaha ʻia ma luna o lākou iho. Aneane nā mea hoʻohana a pau e hoʻomaikaʻi i ka hoʻonui wikiwiki ʻana i ka hoʻonui ʻana i ka nui o ka ʻiʻo a me ke kani.
Nui nā loiloi ma ka pūnaewele e ʻōlelo ana ua ʻike i ka hoʻomaikaʻi ʻana i ke kani o ka ʻiʻo a me ka hoʻonui ʻana i ka nui o ka ʻiʻo, me ka hōʻemi nui o ka momona me ʻekolu a ʻehā mau mahina o ka hoʻohana ʻana i ka pauka 5a hydroxy laxogenin.
ʻO ka 5a-hydroxy laxogenin pauka kūʻai maikaʻi loa?
Hiki ke kūʻai ʻia ka pauda hoʻohui ma o 5a hydroxy laxogenin wholesale suppliers inā pono a hiki ke kūʻai ʻia ma nā mea liʻiliʻi. ʻO ka pauka maikaʻi loa e kūʻai ʻia, ʻo ia ka mea i hana ʻia, mālama ʻia, a hoʻopaʻa ʻia me nā alakaʻi palekana koʻikoʻi no ka mea e hōʻoiaʻiʻo nei kēia i ka pauka ʻole a me nā mea pāpā ʻole 5a hydroxy laxogenin pauka.
E hoʻomaopopo ':
- Mea Kuleana, 5-Alpha-Hydroxy-Laxogenin, E 'ike 'ia ana i loko o nā mea hou aku. Hoʻonaʻauao, ʻuhane o ka haʻuki / Kekemapa 4, 2019
- Bioorg Med Chem. 2012 Apr 15;20(8):2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15. Nā ʻike hou i ka pilina pili-cytotoxicity o spirostan saponins a me nā glycosides pili. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. PMID: 22405922
- YW Zhang, I Morita, L Zhang, G Shao, XS Yao, S Murota. Ka nānā ʻana i nā mea anti-hypoxia/reoxygenation ma ke ʻano in vitro. Māhele 2: Kāohi i ka hoʻoulu ʻana o tyrosine kinase i pale i ka hōʻeha hypoxia/reoxygenation-induced i ka endothelial gap junctional intercellular communication. Planta Med. 2000 Mar;66(2):119-23. doi: 10.1055/s-2000-11126. PMID: 10763583
- Diana M. Cheng, Louis W. Kutzler, Dustin D. Boler, Jenny Drnevich, John Killefer, a me Mary Ann Lilaa. Hoʻomau Infusion o 20-Hydroxyecdysone Hoʻonui i ka nui o Triceps Brachii ma C57BL / 6 Mice. Paʻi ʻia ma ka pūnaewele 2012 Apr 12. doi: 10.1002/ptr.4679. PMC3410052
- ʻO Debora Esposito, Slavko Komarnytsky, Sue Shapses, a me Ilya Raskin. Ka hopena anabolic o ka mea kanu brassinosteroid. FASEB J. 2011 Oct; 25(10): 3708– doi: 10.1096/fj.11-181271. PMC3177571
