Nā kikoʻī kikoʻī o Chenodeoxycholic Acid
| Product Name | ʻAkika Chenodeoxycholic |
| Hawaiian Name | (R)-4-((3R,5S,7R,8R,9S,10S,13R,14S,17R)-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid |
| Sinimona | Chenodeoxycholic Acid;
Anthropodeoxycholic acid; Anthropodesoxycholic acid; CCRIS 2195; Chendol; ʻakika chenic; Chenix; Chenodeoxycholic acid; Chenodesoxycholic acid; Chenodiol; Gallodesoxycholic acid; NSC 657949; Xenbilox |
| Kāleka CAS | 474-25-9 |
| InChIKey | RUDATBOHQWOJDD-BSWAIDMHSA-N |
| hakakino F'Oula | C24H40O4 |
| hakakino Wʻewalu | 392.57 |
| Monoisotopic Mass | 392.29265975 |
| Point Hoʻolālā | 165-167 °C (kukui) |
| 'Ohiʻa Pʻo kaʻaila | 437.26 ° C (kūpono kūpono) |
| nuʻa | 0.9985 (kuhi kūpono) |
| kala like 'ole | ʻO ka mea keʻokeʻo |
| Palekana | INSOLUBLE PONO |
| pūnaewele Tka mahana | lumi lumi |
| noi | Ua hoʻohana ʻia ʻo Chenodeoxycholic acid i kahi noiʻi e loiloi i kona hopena ma ke ʻano he lāʻau hoʻololi lōʻihi no ka cerebrotendinous xanthomatosis (CTX). Ua hoʻohana pū ʻia i loko o kahi noiʻi e noiʻi i kona hopena i ka absorption o ka ʻōpū liʻiliʻi o nā waikawa bile i nā maʻi me ka ileostomies. |
| Hōʻike hōʻike hōʻike | Available |
Chenodeoxycholic ʻakika
ʻO ka chenodeoxycholic acid, ka mea i ʻike nui ʻia ʻo chenodiol, he ʻano bile acid i loaʻa maoli i loko o ke kino o ke kanaka a hoʻohana ʻia hoʻi i waho no nā pono chenodeoxycholic acid. Hoʻohana ʻia ka hoʻohana ʻana i kēia bile acid no ka mālama ʻana i nā ʻano olakino like ʻole a kākoʻo ʻia kēia mau ʻōlelo aʻoaʻo e nā hōʻike ʻepekema. Ua aʻo kikoʻī ʻia ke ʻano hana o ka chenodeoxycholic acid, ma nā haʻawina like ʻole, me ke kumu e ʻike ai i nā hoʻohana, nā pōmaikaʻi, a me nā hopena ʻaoʻao o chenodiol.
He aha ka Bile Acids?
ʻO nā ʻakika bile, e like me ka wehewehe ʻana i ka inoa, nā ʻakika steroidal i loaʻa i loko o ka bile kanaka a me ka bile o nā mammals ʻē aʻe. ʻO ka bile ka wai hoʻoheheʻe i hana ʻia e ke ake a mālama ʻia i loko o ka gallbladder. Hoʻohui ʻia ka hapa nui o nā waikawa bile i loko o ke ake a hiki ke hui pū me nā amino acids; taurine a me glycine, e hana i nā paʻakai bile.
ʻO nā ʻakika bile i hoʻohui ʻia e ke ake i kapa ʻia ʻo ia nā ʻakika bile mua a loaʻa i ka colic acid a me ka chenodeoxycholic acid. Ma mua o ka hūnā ʻana i kēia mau ʻakika bile mua, hoʻololi ʻia lākou i paʻakai bile. Hoʻokuʻu ʻia kēia mau paʻakai bile, a hiki i ka ʻōpū liʻiliʻi. I ka manawa ma ka ʻāpana duodenal o ka ʻōpū liʻiliʻi, ua hoʻoneʻe ʻia nā waikawa amino i hui pū ʻia me ka bile acid e ka pua o ka ʻōpū. Hoʻololi hou lākou i ka hoʻololi ʻana i ka waikawa colic i nā waikawa deoxycholic a me ka waikawa chenodeoxycholic i loko o nā waikawa lithocholic. ʻO nā ʻakika deoxycholic a me lithocholic nā ʻakika bile lua.
Ma muli o ka hoʻohui ʻia ʻana o nā ʻakika bile i loko o ke ake mai ka cholesterol, loaʻa iā lākou kahi pūlima steroid e like me ko lākou kumu. ʻO kēia kekahi o nā kumu e hana ai ka wai bile e like me nā hormones steroid i loko o ke kino a hana i kahi kuleana nui i ka transduction hōʻailona. Eia nō naʻe, ʻo ka hana nui o nā waikawa bile ka hoʻomaikaʻi ʻana i ka hoʻoemi ʻana i nā momona a me nā ʻaila i hoʻopau ʻia, a hana lākou pēlā ma ka hoʻopuni ʻana i ka momona meaʻai, e hana ana i kahi micelle.
Hoʻokumu ʻia ka Micelle i ka wā i uhi ʻia ai nā lipids i loko o ka meaʻai a lawe ʻia i loko o kahi pōʻai i hana ʻia me nā paʻakai bile. Pono e ʻōlelo ʻia aia nā micelles i nā waikawa bile akā ua hana ʻia e nā paʻakai bile e waiho pololei ana ma ka wai a me ka pilina lipid. ʻO ko lākou wahi me kā lākou hydroponic a hydrophilic ʻano e hiki ai i nā paʻakai bile ke hana i kēia mau micelles i ka ʻike kūpono. He mea nui e hoʻomaopopo i ka hoʻokumu ʻana o ka micelle ke kī i ka haki ʻana o ka momona e nā enzymes pono.
He mau hana koʻikoʻi ʻē aʻe nā ʻakika bile, ʻo kekahi o ia ka hōʻemi ʻana i ka pua o ka ʻōpū, he mea koʻikoʻi hoʻi ia no ka hoʻokumu ʻana i nā waikawa bile lua. ʻO ka wehe ʻana i ka cholesterol a me ka hoʻomaʻamaʻa ʻana i ka ʻai ʻana o nā huaora hiki ke hoʻoheheʻe ʻia i ka momona kekahi o nā hana ʻē aʻe o ka wai bile. He koʻikoʻi ko lākou i loko o ke kino o ke kanaka a ʻo kahi mea liʻiliʻi e like me ka hoʻololi ʻana i hiki ke hoʻololi nui i ka physiology o ke kino.
He aha ka Chenodeoxycholic Acid (CDCA) Powder?
ʻO ka Chenodeoxycholic Acid Powder (474-25-9) a i ʻole Chenodiol Powder he waika bile exogenous hiki ke
e hoʻopau ʻia no ka loaʻa ʻana o nā pono like me nā mea i loaʻa mai ka chenodiol endogenous. Hoʻohana ʻia ka pauka i ka lāʻau lapaʻau, ma mua no ka mālama ʻana i nā gallstones, ʻo ia wale nō ka waiho ʻana o ka bile paʻakikī i loko o ka gallbladder. Hiki ke hoʻohana ʻia ʻo Chenodiol i ka mālama ʻana i nā maʻi ʻē aʻe e like me nā pilikia o ka bile synthesis a me ka metabolism. He lāʻau lapaʻau ia i ʻae ʻia e FDA i kuhikuhi pinepine ʻia no nā maʻi o ka ate, i ko lākou kumu, e kū mai nā pilikia me ka bile.
No hea mai ka Chenodeoxycholic Acid Powder?
ʻO ka chenodeoxycholic acid ka mea i hana ʻia e nā cell hepatic mai ka cholesterol. Hoʻokaʻawale ʻia ka pauka exogenous chenodiol mai ka bile o kahi swan, Cygnus melanocoryphus.
Pehea e hana ai ka Chenodeoxycholic Acid Powder?
Hoʻohana mua ʻia ʻo Chenodioxycholic acid powder no ka mālama ʻana i nā gallstones, i hoʻokaʻawale ʻia i ʻelua mau ʻāpana e pili ana i kā lākou ʻike a me ko lākou ʻano ma ka lekiō. Hiki iā Chenodiol ke mālama pono i nā pōhaku i haku ʻia me ka cholesterol a ʻike ʻia ka radiolucent. ʻAʻole mālama ʻia e ka pauka CDCA nā pōhaku ʻeleʻele i radiopaque a i ʻole he radiolucent akā i haku ʻia me ka puaʻa bile.
Hoʻomaʻamaʻa ʻo Chenodiol i nā gallstones ma ka hoʻoheheʻe ʻana i ka cholesterol i loko o ia mau mea ka hopena o ka biliary cholesterol desaturation e ka pauka CDCA. He maʻalahi ka hana o ka chenodeoxycholic acid powder mechanism, no ka mea, ke kāohi nei ia i ka synthesis o ka cholesterol a me ka colic acid i loko o ke ake. I ka wā lōʻihi, hoʻololi ia i ka waikawa cholic a me kāna mau mea i loko o ke kino. No laila ke emi nei ka saturation o ka cholesterol, e koi ana i nā pōhaku cholesterol e hoʻoheheʻe no ke kaulike ʻana i ka cholesterol.
Ke lawe waha ʻia, hele ka chenodiol i ka ʻōpū, kahi e komo ai a hoʻouna ʻia i ke ake no ka hoʻohui ʻana me nā koena taurine a me glycine. Ke hoʻohui ʻia, ʻo ia hoʻi, ua synthesized nā paʻakai bile, hoʻokuʻu ʻia nā paʻakai bile CDCA i loko o ka bile. Noho mau nā paʻakai bile CDCA i loko o ke kahe ʻana o ka enterohepatic, ʻo ia hoʻi, e mau ana nā pae serum a i ʻole pae mimi o CDCA me ka loli ʻole.
He aha ka Chenodeoxycholic Acid i hoʻohana ʻia no?
Hoʻohana ʻia ka pauka Chenodeoxycolic acid no:
- ʻAʻole hiki ke hoʻohana ʻia ka mālama ʻana i nā gallstones radiolucent cholesterol ma muli o ke ʻano o nā kūlana ʻē aʻe e paʻakikī ai ke ʻoki.
- Ka mālama ʻana i ka cerebrotendineous xanthomatosis
- Hoʻomaikaʻi i ka hana ʻōpū a me ka mālama ʻana i ka constipation
- Ka mālama ʻana i nā hewa i hānau ʻia a i ʻole ka lāʻau biliary
- Ka mālama ʻana i ka hyperlipidemia
He aha ka mea nui o ka Chenodeoxycholic Acid i ka ʻai ʻana?
ʻO ka Chenodeoxycholic acid ka mea maikaʻi loa i ka hoʻomaʻamaʻa ʻana i ka lipid digestion ma o ka hana ʻana i nā micelles a puni nā ʻakika momona i lawe ʻia mai ka ʻōpū. ʻO ke kumu o ka hana ʻana i ka micelle a puni nā lipids, ʻo ia ka hoʻoheheʻe ʻana i ka wai i hiki ke lawe ʻia i luna i ka ʻili o ka ʻōpū no ka lawe ʻana maikaʻi. Hoʻokumu ʻia nā micelles e nā paʻakai bile a loaʻa nā ʻakika bile e like me ka chenodeoxycholic acids, no laila, e hoʻolilo i ka hope i mea koʻikoʻi no ka hoʻomaʻamaʻa ʻana i ka digestion lipid i loko o ke kino kanaka.
He aha ia ʻO nā pono a me nā hopena o ka Chenodeoxycholic Acid Powder?
Ua ʻae ʻia ʻo Chenodeoxycholic acid powder e FDA no ka hoʻohana ʻana i ka mālama ʻana i nā gallstones a me kekahi mau maʻi ʻē aʻe. Nui nā pono o ka chenodiol i hōʻike ʻia e nā mea hoʻohana a hōʻoia ʻia e ka ʻikepili ʻepekema. Pono e noʻonoʻo ʻia kēia mau pono i ka wā e kuhikuhi ai i ka pauka CDCA e hōʻoia i ka nui o nā pono ma mua o nā pilikia.
ʻO ka mālama ʻana i nā pōhaku ʻeleʻele ke kuleana nui o Chenodiol, akā naʻe, mālama a mālama wale ia i kahi ʻano ʻano o ka gallstone. Inā ʻaʻole radiolucent ka gallstone a loaʻa ka cholesterol, ʻaʻole lawa ka hoʻohana ʻana i ka pauka CDCA no kona hoʻopau ʻana. ʻO kahi haʻawina i hana ʻia me ke kumu o ka hoʻohālikelike ʻana i nā koho lapaʻau like ʻole no ka cholesterol gallstones ua ʻike ʻia ka hoʻohana ʻana i ka chenodiol me ka lithotripsy ka lāʻau koho. Manaʻo nui ʻia ʻo Chenodiol inā ʻaʻole hiki ke koho ʻia ka ʻoki ʻana i ka ʻōpū o ka ʻōpū.
ʻO ka Chenodeoxycholic acid powder pono pū kekahi me ka mālama ʻana i nā maʻi metabolic e like me cerebrotendinous xanthomas. Aia kēia maʻi i kahi hoʻololi genetic i loko o ka gene e hoʻopili ai i ka enzyme e pono ai no ka hoʻololi ʻana o ka cholesterol i nā waikawa bile i loko o ke ake. ʻO ka loaʻa ʻole o kēia enzyme ka hopena i ka hōʻemi ʻana o ka bile acid synthesis a me ka piʻi nui o ka cholesterol e hōʻiliʻili ʻia ma nā wahi like ʻole o ke kino, no laila, hoʻokumu ʻia nā xanthomas. ʻO ka mālama ʻana me nā waikawa bile exogenous e like me chenodiol e kōkua i ka hōʻemi ʻana i ka cholesterol i loko o ke kino a hoʻomaikaʻi i nā hōʻailona o kēia maʻi genetic.
ʻO ka Chenodeoxycholic acid, me kāna epimer, ursodeoxycholic acid, ua manaʻo ʻia he mau antioxidant a me nā waiwai anti-inflammatory, ʻoiai ʻike ʻia kēia mau pōmaikaʻi me ka ursodiol. He mea pono hoʻi ʻo Chenodiol i ka mālama ʻana i nā hewa i hānau ʻia o ka metabolism a me nā maʻi ate ʻē aʻe.
Pehea e lawe ai i ka Chenodeoxycholic Acid Powder?
(1) Ma mua o ka lawe ʻana i ka pauka chenodiol
Ma mua o ka hoʻomaka ʻana e lawe i ka pauka chenodeoxycholic, makemake nui ʻia e haʻi aku i ke kauka kuhikuhi i nā lāʻau lapaʻau āpau a me nā wā i hala a me nā kūlana olakino e hōʻoia ai ʻaʻole hiki ke hoʻopili ʻia e hiki ke hopena i nā hopena make. No ka laʻana, he nui nā hopena ʻaoʻao o ka CDCA e pili pono ana i ka hana o ke ake a ʻo ia ke kumu e contraindicated ai ka hoʻohana ʻana i ka maʻi ate. He mea nui nō hoʻi e haʻi aku i ke kauka i nā mea allergies i nā mea i loko o ka papa chenodiol a i ʻole ka pauka, e hōʻoia i ka hōʻemi ʻana o nā hopena ʻaoʻao.
(2)Chenodeoxycholic aka pauda cid
Pono e lawe waha ʻia ka pauda Chenodiol, me ka ʻai a me ka ʻole. ʻO ka chenodeoxycholic acid powder dosage e pili ana i ke kaumaha o ke kanaka, ke kūlana olakino e hoʻohana ʻia ana, a me ka pane ʻana i ka lāʻau. ʻO ke ʻano o ka ʻaoʻao hope ʻo ia ka ʻokoʻa o ka hopena mua a me ka mālama ʻana o ka pauka chenodeoxycholic acid ma muli o ka maikaʻi a i ʻole ka hopena o ke kino. ʻO ka mea maʻamau, no ke kanaka makua, aia ke ʻano ma waena o 13 mg a me 16 mg no ka kilo o ke kaumaha.
Hoʻohana mua ʻia ka pauka Chenodiol no ka mālama ʻana i nā gallstones, a no ka mea hiki iā lākou ke lōʻihi no ka haki ʻana a me ka excretion, hiki ke hoʻohana ʻia ka pauka a hiki i ʻelua makahiki. Eia nō naʻe, ma hope o 2 mau makahiki, pono e kāpae ʻia ka hoʻohana ʻana i ka waika chenodeoxycholic no ka mea he nui nā hopena hepatotoxic o ka bile. Eia kekahi, ʻo nā hōʻailona o ka gallstones a i ʻole nā maʻi biliary ʻē aʻe e hala i hoʻokahi makahiki e nalowale me ka hoʻohana ʻana i ka pauka CDCA.
(3) He aha ka hopena inā haʻalele au i kahi maʻa or overdose?
I ka hihia o ka pauka chenodiol i hala, ʻoi aku ka maikaʻi o ka waiho ʻana a lawe i ka hopena hou i ka manawa maʻamau. Hiki i ka hoʻopaʻa ʻana pālua ke alakaʻi i ka overdose a ʻaʻole ʻōlelo ʻia. ʻOiai ʻaʻole nui nā overdoses i hōʻike ʻia me ka pauka chenodiol, aia kekahi mau mea e hōʻoia i ka ʻōlelo aʻo. Inā manaʻo ʻia ka overdose a pilikia ka hanu o ka mea i hoʻopilikia ʻia, pono e ʻimi koke ʻia ke kōkua olakino.
(4)He aha kaʻu e pale ai i ka lawe ʻana i ka chenodiol?
ʻO ka hoʻohana ʻana i ka pauka chenodeoxycholic acid i contraindicated i kekahi mau kūlana, e like me:
- hepatitis
- ʻO Cirrhosis
- ʻO ka maʻi maʻi
- ʻO ka maʻi pancreatic
- Keakea ma ka opu
- Hemolytic anemia a i ʻole nā maʻi ʻē aʻe a i ʻole hemolysis
- Hoʻohana mau i ka waiʻona
- Hana ʻino
- hāpai keiki
ʻO ka hoʻohana ʻana i ka chenodiol i ka wā o ka hāpai ʻana he teratogenic koʻikoʻi i ka fetus a ua contraindicated loa ia. I ka wā o ka hānai ʻana, ʻaʻole naʻe i ʻike ʻia inā komo ka bile acid CDCA i ka waiū umauma a no laila, ʻaʻole i ʻike ʻia. E kūkākūkā i ke kauka ma mua o ka hoʻomaka ʻana e lawe i ka pauka chenodeoxycholic acid i ka wā e aʻo nui ʻia ai ka hānai.
He aha nā lāʻau lapaʻau ʻē aʻe e hui pū me Chenodeoxycholic Acid?
ʻO nā hopena ʻaoʻao o ka chenodeoxycholic acid i hōʻike ʻia ma muli o ka hopena o ka bile acids pololei, a ʻaʻole loa ma muli o ka launa pū ʻana o ka pauka me nā lāʻau lapaʻau ʻē aʻe. ʻAʻole ia, akā, ʻaʻole e launa pū ka chenodeoxycholic acid pauka me nā lāʻau ʻē aʻe. Inā lawe ʻia ka chenodiol me nā hua lāʻau a i ʻole nā lāʻau lapaʻau, e loli nui ka hopena o ka pauka. E piʻi aʻe ka pilikia o ka hoʻomohala ʻana i nā hopena ʻino me kēia mau pilina.
ʻO nā lāʻau lapaʻau kūikawā ʻaʻole hiki ke launa pū me ka pauka chenodeoxycholic acid:
- Cholestyramine
- ʻO Colestipol
- ʻO nā lāʻau hoʻomalu hānau a i ʻole ka lāʻau hoʻololi homoni
- ʻO nā antacids i loaʻa i ka alumini ka mea nui e like me Almacone, Gelusil, Maalox, Mag-al Plus, Mylanta, Rulox, a me nā mea ʻē aʻe.
- ʻO nā mea hoʻokahe koko e like me warfarin, Coumadin, Jantoven.
ʻO Cholestyramine a me colestipol nā mea hoʻopaʻa wai bile e hana i loko o ka ʻōpū ma ka hoʻopaʻa ʻana i nā waikawa bile, no laila, ke kāohi nei i kā lākou hana. ʻO ka lawe ʻana i ka waika bile sequestrants me ka bile acid e hoʻonui i ka hope a ʻaʻole ʻike ʻia nā pōmaikaʻi. Akā, ʻoi aku ka ʻino o ka maʻi olakino i kuhikuhi ʻia ai ka chenodeoxycholic acid.
He mea nui ʻaʻole e lawe i ka chenodiol me nā ʻano ʻano bile ʻē aʻe no ka mea hiki ke hoʻonui i ka hopena o nā hopena ʻaoʻao. Manaʻo nui ʻia e nānā me ke kauka a haʻi iā lākou i nā huaora a i ʻole nā lāʻau lapaʻau e lawe ʻia e kekahi, ma mua o ka hoʻomaka ʻana i ka chenodiol no ka mea pono e hoʻōki kekahi mau lāʻau ma mua o ka hoʻomaka ʻana i ka chenodeoxycholic acid. ʻAʻole ʻo ia wale nō, ʻo ka haʻi ʻana i nā lāʻau lapaʻau i hoʻohana ʻia a hoʻopau ʻia paha he mea maikaʻi paha no ka mea hiki i kekahi mau lāʻau ke noho i loko o ka ʻōnaehana no ka manawa lōʻihi.
He aha nā ʻokoʻa ma waena o Ursodeoxycholic Acid Powder a me Chenodeoxycholic Acid Powder?
ʻO Chenodeoxycholic acid pauka a me Ursodeoxycholic acid pauka ʻelua o ka nui o ka exogenous bile acids i kuhikuhi ʻia a hoʻohana ʻia no ka mālama ʻana i nā gallstones.
Ursodeoxycholic acid pauka
ʻO Ursodeoxycholic acid pauka a i ʻole ursodiol he waika bile lua i loko o ke kino o ke kanaka, i hoʻohui ʻia mai ka hoʻololi ʻana i nā paʻakai bile e ka pua o ka ʻōpū. ʻAʻole like me ka chenodeoxycholic acid ka mea mua bile acid a synthesized i loko o ke ake, ua synthesized ka ursodiol i loko o ka ʻōpū liʻiliʻi. Hoʻopuka ʻia ka pauka ursodeoxycholic acid exogenous mai ka cholic acid i lawe ʻia mai ka bile bovine.
Hoʻohālikelike i nā pono a me ka hana
Hoʻohana ʻia ʻo Ursodiol a me Chenodiol no ka hoʻoheheʻe ʻia ʻana o ka gallstone, akā naʻe, ʻaʻole like ka hoʻohana ʻana o nā mea ʻelua. Hoʻohana ʻia ʻo Ursodiol no ka mālama ʻana i ka cholangitis biliary mua a me ka sclerosing cholangitis. Ma muli o kona kūlana palekana kiʻekiʻe, ʻo ursodiol ka bile acid i koho ʻia no ka mālama ʻana i ka intrahepatic cholestasis o ka hāpai ʻana.
Nā ʻokoʻa nui
ʻO ka ʻokoʻa nui ma waena o ka pauka chenodeoxycholic acid a me ka pauka ursodeoxycholic acid ʻaʻole ia he hepatotoxic ka hope a hiki ke hoʻohana manuahi ʻia ʻoiai he hepatotoxic ka mea mua a hiki ke hōʻeha i ka maʻi ate. ʻO Chenodiol kahi waikawa bile mua a ʻo Ursodiol ka lua bile acid me ka epimer o chenodiol.
ʻO nā haʻawina hou i hana ʻia me ke kumu o ka hoʻohālikelike ʻana i ka ursodiol a me ka chenodiol ua ʻoi aku ka maikaʻi o ka UDCA i ka hōʻemi ʻana i ka nui o nā gallstones ma ka hōʻailona 3-malama a me 6-malama. Eia naʻe, ma hope o 12 mau mahina ua kaulike ka pono o ka chenodiol a me ka ursodiol a ʻaʻohe ʻokoʻa koʻikoʻi ma waena o nā mea ʻelua. Eia kekahi, ua ʻike ʻia hiki iā Ursodiol ke hoʻopaʻa pono a mālama i nā pōhaku nui a liʻiliʻi ma nā mea ʻelua, nā kiʻekiʻe a me nā haʻahaʻa haʻahaʻa. ʻO Chenodiol, ma ka ʻaoʻao ʻē aʻe, ʻoi aku ka maikaʻi o ka hōʻemi ʻana i ka nui o nā gallstones liʻiliʻi ma nā kiʻekiʻe kiʻekiʻe.
Wahi a kekahi noiʻi ʻē aʻe, pili ka chenodiol ma nā haʻahaʻa haʻahaʻa me ka piʻi ʻana o ka cholecystectomy.
He aha nā hopena ʻaoʻao o Chenodeoxycholic Acid?
Ke kuhikuhi ʻia ka chenodeoxycholic acid, ʻōlelo ʻia e hahai pinepine me ka mea maʻi. Pono e ho'āʻo koko i kēlā me kēia huakaʻi hele me ka manaʻo nui e pili ana i nā enzymes ate. ʻO kēia ma muli o ke ʻano hepatotoxic o ka chenodeoxycholic acid. Hiki ke hoʻokaʻawale ʻia nā hopena ʻaoʻao o ka chenodeoxycholic acid i ʻelima mau ʻāpana, e pili ana i ka ʻōnaehana okana i hoʻopilikia nui ʻia e nā hopena ʻaoʻao:
Nā hopena ʻaoʻao Hematologic
Ua hōʻike ʻia kekahi mau hihia o nā hopena ʻaoʻao hematologic, me nā poʻe āpau i hōʻike ʻia i ka emi nui ʻana o ke kahe koko keʻokeʻo. ʻAʻole i hāʻule ka manaʻo ma lalo o 3000 a ʻoiai ʻo kēia emi ʻana, ua ʻae maikaʻi ʻia ka lāʻau lapaʻau. ʻAʻole i hana ʻia ka hoʻoholo no ka hoʻopau ʻana i ka pauka CDCA no kekahi o kēia mau maʻi no ka mea ʻaʻole i hāpai kēia hopena ʻaoʻao i nā pilikia olakino.
Nā hopena ʻaoʻao hepatic
ʻO ka Chenodeoxycholic acid pauka he hepatotoxic a ʻo ia ke kumu i contraindicated ai kona hoʻohana ʻana i nā maʻi ate. Eia kekahi, hiki ke koʻikoʻi ka hepatotoxicity o ka pauka CDCA i mea koʻikoʻi ka nānā mau ʻana i nā enzyme ate ke hoʻomaka ka lāʻau. ʻAʻole ʻike pinepine ʻia kēia mau hopena ʻaoʻao inā e mālama pono ʻia nā hana e like me ka nānā ʻana i ka hana ate. ʻO ka hoʻohana ʻana i ka pauka chenodiol me ka ʻole o ka nānā ʻana i nā hoʻokolohua hana o ke ake e hiki ke hoʻoweliweli i ke ola a me ka maʻi.
ʻO nā hōʻailona o ka maʻi ate e hōʻike iā lākou iho me ka hepatotoxicity o chenodiol:
- Ka melemele o nā maka
- ʻIli melemele
- ʻO kaʻeleʻeleʻeleʻele
- Ka luhi a me ka lethargy
- ʻO kaʻeha hope o kaʻeha
- Nausea a me ka luaʻi ʻaʻole e hoʻonā
Nā hopena ʻaoʻao o ka ʻōpū
Hiki ke ʻike ʻia kēia mau hopena ʻaoʻao i kēlā me kēia manawa i ka wā o ka hoʻolālā lapaʻau akā naʻe, ʻike pinepine ʻia lākou i ka wā i hoʻomaka mua ai ka mālama ʻana. He hopena ʻaoʻao maʻamau kēia e like me ka hapa nui o nā lāʻau i ka wā i hoʻohana mua ʻia ai, hiki ke hoʻoulu i ka ʻeha o ka ʻōpū. Ma kahi o 30 pakeneka i ka 40 pakeneka o ka poʻe e lawe ana i ka chenodiol hōʻike i ka maʻi maʻi i ʻae ʻia a ʻaʻole paʻakikī. ʻO ka 15 pakeneka wale nō o ka poʻe e loaʻa ana i ka maʻi maʻi e pili ana i ka maʻi maʻi i koi ʻia e hoʻemi ʻia. Ua hōʻike kekahi i ka hoʻomaikaʻi ʻana i nā hōʻailona ma hope o ka hoʻohana ʻana i nā lāʻau anti-diarrheal.
Kakaʻikahi, koi ʻia ka hoʻopau ʻana i ka chenodiol ke koʻikoʻi ka maʻi maʻi a hele pū ʻia me nā ʻōpū o ka ʻōpū. Ma mua o ka hoʻopau ʻana i ka lāʻau lapaʻau, pono e hoʻokaʻawale i waena o ka maʻi diarrheal mai ka colicky, ʻeha ʻōpū i loaʻa me nā gallstones. ʻO ka huikau i ka hope me ka mea mua a me ka hoʻopau ʻana i ka pauka CDCA hiki ke hōʻino i ke olakino holoʻokoʻa.
ʻO kekahi o nā hopena ʻaoʻao o ka gastrointestinal rarer,
- ʻO ka naʻi a me ka luaʻi
- Pākaha
- Kuʻikena
- Ka hoʻomau
- ʻO Dyspepsia
- ʻEha ʻōpū maʻamau
- Ke ahi
- Anorexia
Hoʻopaʻa Kolesterol
Hiki ke ʻike ʻia he 10 pakeneka o ka hoʻonui ʻana o ka cholesterol a me nā momona maikaʻi ʻole, LDL, me ka hoʻohana ʻana i ka pauka chenodeoxycholic acid. Ua hōʻike pū kekahi mau wahine e lawe ana i ka wai bile i ka piʻi haʻahaʻa o kā lākou mau triglycerides, me ka nui o ka cholesterol a me nā pae LDL. ʻAʻohe loli i ka HDL a i ʻole nā momona maikaʻi i hōʻike ʻia.
ʻO ka wehe ʻana o ka gallbladder a i ʻole ka helu cholecystectomy
ʻO ka poʻe me nā pōhaku ʻōpū a me ka mōʻaukala o ka ʻeha biliary e koi pinepine i kahi kaʻina hana cholecystectomy ma ke ʻano he lapaʻau no ko lākou mau ʻōpū. Eia kekahi, ʻaʻole hiki i kēia mau maʻi ke ʻae i ka pauka chenodeoxycholic acid kiʻekiʻe a ua hāʻawi ʻia i nā haʻahaʻa haʻahaʻa. ʻAʻole hiki ke ʻae i ka pauka CDCA kiʻekiʻe, no laila, ua pili pū me ka piʻi ʻana o ka nui o ka cholecystectomy.
He aha nā hana e hana ʻia e hōʻoia i ka hoʻohana palekana a me ka maikaʻi o ka Chenodeoxycholic Acid?
Hana nā limahana mālama ola a me nā kauka lapaʻau maʻamau i nā kipa e nānā pono i nā hopena ʻaoʻao o ka pauka chenodeoxycholic acid e hōʻoia i kona palekana a me ka pono holoʻokoʻa o ka pauda.
Ma hea e hiki ai iaʻu ke loaʻa ka ʻike hou aku e pili ana i ka Chenodeoxycholic Acid Powder i kūʻai ʻia?
No ka 'ike hou aku e pili ana i ka chenodeoxycholic acid powder kuai i ka nui, hiki iā'oe ke ho'ohana i nā kumuwaiwai pūnaewele e like me nā pūnaewele o nā mea hana like'ole chenodeoxycholic acid powder.
ʻImi hou aʻe e pili ana i ka Chenodeoxycholic Acid
Ke aʻo ʻia nei ka ʻakika Chenodeoxycholic no nā hoʻohana ʻē aʻe o ka pūhui, ʻokoʻa ka hoʻohana ʻana i ka biliary-specific. Ke aʻo nei kahi hui biotechnology Australia i kēia manawa i ka chenodiol i hui pū ʻia me kahi lāʻau hoʻohaʻahaʻa lipid, bezafibrate no ka mālama ʻana i ka Hepatitis C.
Pinepine ninau ninaninau 'ana i
(1)No ke aha mai chenodeoxycholic acid (chenodiol) wale no ka poe koho?
ʻO Chenodiol kahi waikawa bile ikaika e hiki ke kōkua i ka mālama ʻana i nā gallstones. Eia nō naʻe, he hepatotoxic a hiki ke hoʻoulu i ka maʻi ate koʻikoʻi. ʻO ia ke kumu ʻaʻole ʻōlelo ʻia no ka poʻe me ka maʻi ate no ka mea hiki ke hoʻonui ʻia nā hōʻailona o ka maʻi e ka bile acid.
(2)Hiki iaʻu ke lawe iā Chenodal (chenodiol) inā hāpai au?
ʻAʻole ʻōlelo ʻia ka hoʻohana ʻana i ka chenodiol i ka wā hāpai ma muli o ka hiki ke teratogenic o ka lāʻau lapaʻau.
(3)Pehea ka lōʻihi e lawe ai au iā Chenodal (chenodeoxycholic acid)?
Hiki ke lawe ʻia ʻo Chenodal a hiki i ʻelua makahiki i ka manawa, a hiki ke lawe i ka chenodeoxycholic acid CDCA pauka a hiki i hoʻokahi makahiki e hoʻohaʻahaʻa i nā hōʻailona a mālama i ke ʻano. Ma hope o ka hoʻohana ʻana i ka pauka CDCA no ʻelua mau makahiki, he mea nui e hoʻomaha.
(4)No ke aha e noi ʻia ai au e ʻike i kaʻu mea hoʻolako i kēlā me kēia manawa no nā hoʻokolohua?
Ke ho'āʻo nei kāu mea hoʻolako i kāu mau enzymes a me nā pae cholesterol e hōʻoia i nā mea a pau i loko o ka laulā maʻamau, a ʻaʻohe hopena maikaʻi ʻole o ka chenodiol i kou olakino holoʻokoʻa. Ma muli o ke ʻano hepatotoxic nui o ka pauka CDCA a me kona hiki ke hoʻoulu i ka maʻi ate me ka wikiwiki, e nīnau kāu mea hoʻolako chenodeoxycholic acid iā ʻoe i kēlā me kēia manawa no nā hoʻokolohua. Ua ʻike pū ʻia ka piʻi ʻana o nā pae cholesterol me ka hoʻohana ʻana i ka chenodiol, ʻo ia kahi hoʻāʻo ʻē aʻe a kāu mea lawelawe e noi ai iā ʻoe.
(5)He aha nā lāʻau e pono iaʻu ke pale i ka wā e lawe ana iā Chenodal (chenodiol)?
I ka lawe ʻana iā Chenodiol, pono ʻoe e hoʻokele i ka bile acid sequestrants e like me cholestyramine a me colestipol e like me kā lākou e launa pū ai me ka pauka CDCA a hoʻololi i kāna hoʻohana. ʻAʻole ʻōlelo ʻia e lawe i nā anticoagulants e like me warfarin a me coumadin, nā lāʻau hoʻomalu hānau me ka estrogen i loko o ia mau mea, a i ʻole nā antacids a me nā lāʻau ʻē aʻe i loaʻa ka alumini. Inā ʻoe e lawe ana i nā huaora, nā mea hoʻohui lāʻau, a me nā kī lāʻau, a i ʻole ua hoʻōki wale ʻoe i ka lawe ʻana i kahi lāʻau lapaʻau, pono ʻoe e haʻi i kāu kauka e hōʻoia i ka ʻole o kāu mau lāʻau i kēia manawa a i ʻole nā lāʻau lapaʻau e pili ana me chenodiol.
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