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ʻO ka māmā maemae sodiumʻo Tianeptine (30123-17-2)

ʻO ka paina māmā sodonaʻo Tianeptine, he mea'oniʻoki kēia, he mea kohoʻo 5-HT (serotonin, sc-201146) i loko o ka vitio ....


Kūlana: I ka Production Production
Mokuna: 25kg / Drum
nona iho: 1290kg / ka mahina

Description

ʻO ka paʻi maemae sodiumʻo Tianeptine (30123-17-2) wikiō

ʻO ka māmā maemae sodiumʻo Raneptine (30123-17-2) Hōʻike

Product Name ʻO ka māmā maemae sodiumʻo Tianeptine
Hawaiian Name ʻO Tianeptine sodium; ʻO ka paʻakai sodium Tianeptine; 30123-17-2; ʻO Stablon; ʻO Coaxil;
Brand Name N / A
Kōpana Drug N / A
Kāleka CAS 30123-17-2
InChIKey HNTRDGDHBBFLPG-UHFFFAOYSA-M
hakakino F'Oula C21H24ClN2NaO4S
hakakino Wʻewalu 458.93
Monoisotopic Mass 458.104 g / mole
Hoʻolaha Pʻo kaʻaila 1800C
ʻOhiloa Pʻo kaʻaila 609.2 ° C ma 760 mmHg
ʻO ka Halifa-Ola N / A
kala like 'ole ʻO ka'ōmaʻomaʻo i ka paukūʻeleʻele
Solakino DMSO: ≥20mg / mL
Ska hoʻokele Tka mahana Desiccate ma RT
Apaukū ʻO ka māmā māmāʻo Tēneptine he māmā o Tianeptine.

ʻO ka dianeptine he antidepressant.

ʻO ka māmā maemae sodiumʻo Raneptine (30123-17-2) Hōʻike

ʻO ka paʻakai sodium Tianeptine he paʻakaiʻo Tianeptine. ʻO Tianeptine, kahiʻaila tricyclic, he mea kohoʻo 5-HT (serotonin, sc-201146) ke kumuhana i loko o vitro a i loko o vivo. Hoʻohuiʻia, ua hōʻikeʻiaʻo Tianeptine e hana i mea hōʻailona koho o ka hoʻoponopono dopamine a ke like me ka amineptine. ʻAʻole loaʻa ka mana o ka dianeptine i ka hopena monoamine. I loko o kahi aʻoʻana e hoʻohana ana i nā synaptosomes i hoʻomaʻemaʻeʻia mai ka lolo roro, ua hōʻikeʻiaʻo Tianeptine e hoʻonui i ka nerotonin i nā koho o ka lolo. Ua loaʻa nā synaptosomes hoʻomaʻemaʻeʻia mai nāʻiole mai a hoʻopiliʻia me ka inoaʻo 5-HT a me ka dianeptine i loko o ka vitium. Hoʻopiliʻia nā synaptosomes no ka mālama a hoʻokuʻuʻana i ka 5-HT ma o ka helu'enemo wai.

ʻO ka māmāʻo Tianeptine ka paʻakai paʻakai sodium he antidepressant atypical me nāʻanoʻokoʻa, he nui ma luna o ka pūnaewele glutamater.It ke hoʻopau nei i ka hoʻokuʻuʻana i ka glutamate a hoʻololi i ka hana o ka receptor AMPA.Tianeptine ka hana like o ka agonist o ka'āpana o ka μ-opioid (EC50s = 194 a me 641 nM no nā haipule kanaka a me nā kiole, kekahi). He kūpono loa ia e like me ka fluoxetine i ka mālamaʻana i ka maʻi hōʻaleʻa hope.

ʻO ka paakai sodona Tianeptine he mana nootropic e pili ana i nā mea i hoʻoihoʻoleʻia ka hopena e nā maʻi o ke kino a he hiki ke hoʻonui i ka hilinaʻi a me ka hoʻonākau i loko o ka poʻe iʻikeʻole i ka naʻau.

ʻO ka māmā maemae sodium Tianeptine (30123-17-2) Mechanism of Action

Hōʻike nā mea hou i nā hana dianeptine ma keʻano he agonist piha ma ka lipopid receptor (MOR). Ua ho'āʻoʻo Tianeptine i ke kuhiakau hoʻokahi o ka naʻau kaumaha, a me nā hana i kākoʻo nuiʻia e ka mea i ho'ākākaʻia ai nā hana o nā mea antidepressants. ʻO ke kaulike, ua manaʻoʻia kēia lāʻau lapaʻau i ka hoʻololi pinepineʻana i ka hōʻailona hōʻailona koho o ka hippocampal CA3 hui pūʻulu hui. Ke hōʻikeʻia nei nā dianeptine i kāna hopena antidepressant ma o ka hoʻololiʻana o ka hana hoʻopihapiha glutamate (e like me nā mea hōʻailona AMPA a me nā nīkia NMDA) a pili i ka hoʻokuʻuʻana i ka helu neurotrophy (BDNF) i loaʻa i ka lolo, e pili ana i ka'eneʻenaʻenaʻena. ʻO nā haʻawina hou aku nei ma ke kākoʻoʻana i keʻano o ke dianeptine i ka hoʻololiʻana i ka hana holoʻona i ka amygdala, kahi pili o nā manaʻo hoʻomanaʻo.

Hoʻopiʻiʻo Tianeptine i ka pane hypothalamic-pituitary-adrenal i ka pilikia, a pēlā e pale ai i nā hihia halihali pili i ka pilikia. Ma nā koʻi, ke koʻikoʻi o ka kaohi āpau e hoʻonui i ka nui o ka glutamate ma ka amygdala basolateral ka hopena iʻaʻaʻia e ka dianeptine. ʻO ka mea e mahalo ai, ua hoʻonuiʻia ka SSG fluoxetine i ka piʻiʻana o ka'āpana kalapona i loko o ka amygdala basaltral me ka nānāʻole i nā kūlana kaumaha. Hōʻike kēia mauʻike i keʻano o ka hana o ka dianeptine e pili ana i SSRI a kākoʻo i ke kuhiakau e like me ka hana o ka dianeptine e pili ana i ka hoʻololiʻana i kaʻoihana glutaminergic ma ka amygdala a me ka hippocampus.

Ma waho aʻe o nā hana i luna, he dianeptine kū hoʻokahi a me ka lāʻau o ke anuanu e hoʻonāukiuki i ka mālamaʻana i ke serotonin (5-hydroxytryptamine; 5-HT), a me ka 5-hydroxyindoleacetic acid (5-HIAA) i loko o ka lolo.

ʻOiai uaʻikeʻia keʻano o ka serotonin neurotransmitters (5-HT), noradrenaline (NA) a me dopamine (DA) i ka hopena o nā maʻi hoʻonāwaliwali, uaʻikeʻia i kēia manawaʻaʻole lawa nā hapaʻai monoamine e wehewehe i ka hana o ka antidepressant nā lāʻau.

maika of ʻO ka māmā maemae sodium Tianeptine (30123-17-2)

  • Hiki i ka paʻakai sodona Tianeptine ke mālama i nā maʻi kaumaha nui.
  • ʻO ka paʻakai sodonaʻo Tianeptine he pāʻani a me ka antidepressant a me nāʻano nootropic.
  • ʻO ka hānai sodium Tianeptine e hoʻonui i ke ola a hoʻomaikaʻi i ka kūlana o ka manaʻo.
  • ʻO ka paʻakai pa'ūnekiʻo Tianeptine e hiki ke pale i nā pōpilikia mai ka hopena.
  • ʻO ka paʻakai sodona Tianeptine e paʻiʻia i kaʻeha e pili ana me fibromyalgia.
  • ʻO ka paʻakai sodium Tianeptine i hoʻohana ʻia i ka mālama ʻana i ke kaumaha i nā kāne me ka hanaʻole.
  • ʻO ka paʻakai pa'ūnekiʻo Tianeptine he mana maikaʻi loa no ADHD.
  • Mālamaʻia ka paʻakai sodium Tianeptine i nā neuroplasticity.

pono ʻO ka māmā maemae sodium Tianeptine (30123-17-2) Hana

He wahi hapaʻuʻukuʻo Tianeptine Sodium i ka manawa wale nō e pili ana i 2.5 mau hora14, a koi aku iʻelua kaukeli i kēlā me kēia lā. ʻO ka helu sodium deneneptineʻo 12.5 mg ia iʻekolu manawa i kēlā lā i kēia lā, no ka 37.5mg a pau no ka lā.

Mai hoʻonui i ka 50mg o Tianeptine Sium i ka lā hoʻokahi. ʻO ka hanaʻana pēlā e hiki ai ke wehe i ka puka no ka hoʻomaʻamaʻa hou a me ka hōʻailona paha.

Nā hopenaʻaoʻao ʻo ka paina maemae sodium Tianeptine (30123-17-2)

ʻO ka māmā me ka nui o nā māhele o ka lolo e like me nā pepeiao o ka lolo, hiki ke hana i ka hopena o ka euphoria. ʻO nā hopenaʻokoʻa'ē aʻe me keʻano likeʻole o kēia mau mea:

Heʻehi (a hiki i ka 18%)

Dizziness (a hiki i 10%)

Nā hopohopo hoʻonanei / pō (e hiki i ka 20%)

Pākuʻi (a hiki i 10%)

ʻO kahi waha (a hiki i 20%)

ʻO nā hopena'ē aʻe e pili ana i nā mea like constipation, nausea, manaʻo hopohopo, a me nā meaʻona. ʻO nā pilikia nui aʻe e pili ana i ka weheʻana ma hope o ka hanaʻino aʻo ka mea i manaʻoʻia e 0.1 - 0.3% o nā mea hoʻohana i kēia pilikia. Pehea ka wā, e like me kāu eʻike ai, nā hopena ākea o ka paʻakai paʻakai o Tianeptine e hilinaʻi ma luna o kēlā me kēia pilikino pono'ī.

He mea kūpono eʻike i kēia:

Pono nā poʻeʻelemakule e lawe i ka liʻiliʻi liʻiliʻi o ka paʻakai sodium Tianeptine, e like me ka poʻe maʻi me ka hōʻinoʻole. ʻAʻole pono e hoʻololiʻia ka hanaʻana i nā maʻi me ka maʻi a me ka hōʻinoʻole hepikipiki, aiʻole nā ​​mea maʻi i ka dialysis .Ui hoʻonuiʻia ka maʻi o ka ate me he mau diabolic, like dianeptine.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.


ʻO Shangke Chemical he polokalamu kelehana kiʻekiʻe e kū nei i nā mea hana hana hoʻopihamaha hana (APIs). No ka mālamaʻana i ka maikaʻi i ka manawa o ka hanaʻana, kahi nui o nāʻoihana akamai, nā mea hana papa hana mua a me nā hale liʻiliʻi i nā kumu nui.

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