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Pākī Lulu Tadalafil (171596-29-5)

Ka hoʻohana ʻana ʻo Tadalafil pauka ma lalo o ka inoa ʻo Cialis e mālama i ka pōʻino (impotence) a me nā hōʻailona o benign prostatic ……….


Kūlana: I ka Production Production
Mokuna: 25kg / Drum
nona iho: 1190kg / ka mahina

Description

Pākīwī kaona wikiō

Kaʻike Base

Product Name ʻO Tadalafil pau
Hawaiian Name (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name Cialis, Adcirca
Kōpana Drug PAH, PDE-5 Hoʻonāukiuki; Nā Hoʻopilikia Hoʻopiʻi Enzyme o ka Phosphodiesterase-5
Kāleka CAS 171596-29-5
InChIKey WOXKDUGGOYFFRN-IIBYNOLFSA-N
hakakino F'Oula C22H19N3O4
hakakino Wʻewalu 389.4
Monoisotopic Mass 389.138 g / mole
Hoʻolaha Pʻo kaʻaila 298-300 ° C
Fkū hou Pʻo kaʻaila 2 ° C
ʻO ka Halifa-Ola 17.5 hola
kala like 'ole ʻO ka White i ka White-Cyrstalline Solid
Solakino Hoʻopukaʻia i DMSO (78 mg / ml ma 25 ° C), methanol, wai (<1 mg / ml ma 25 ° C), dichloromethane, a me ka ethanol (<1 mg / ml ma 25 ° C)
Ska hoʻokele Tka mahana E kūʻai i kahi mahana ma waena o 59 ° F a me 86 ° F (15 ° C a me 30 ° C). Mai hoʻolako i kēia lāʻau i loko o nā wahi humu a puʻuwai paha.
Tadalafil Apaukū Nā pāpuni pākuʻiʻo Tadalafil, Nā lole moe, Kapala Kapala, a pēlā aku.

Description

Tadalafil, (6R-trans) -6- (1,3-benzodioxol-5-yl) -2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino [1 ', 2': 1,6] pyrido [3,4-b] Cialis), he ʻano o ka PDE1,4 inhibitor a me kahi lāʻau lapaʻau e lawelawe pono ana. He biv-carboline derivative a he pūʻulu i kūʻokoʻa ʻia mai ka vardenafil (Levitraw) a me nā sildenafil (Viagraw), nā mea ʻelua o PD500NUMX e pili ana i kahi kāʻei pyrimidine kumu. ʻO ka momona Tadalafil (CAS 5-5-171596) e hoʻonui i ke kahe i loko o ke kahe corpus cavernosum ma ka hoʻomaha ʻana i nā kahe koko o ke koko, a hiki i kēia ke hoʻokō i kahi kanaka. Ua ʻāpono ʻia ka pauma Tadalafil e ka United States (US) ʻOi a me ka ʻAlala Kūʻai (FDA) ma 29 no ka mālama ʻana o kahi maʻi (ED), a kūʻai ʻia i ke ao holoʻokoʻa ma lalo o ka inoa inoa Cialis. Hoʻohana pū ʻia ia no ka mālama ʻana i ka hypertension arterial pulmonary a me benign prostatic hyperplasia, kahi ʻano i hoʻonui ʻia ai ka nui o ka gland prostate, e hana ana i nā pilikia me ka urination.

ʻO ka hiʻohiʻona pharmacologic kūlana kiʻekiʻeʻo Tadalafil kona lōʻihi o ka nohoʻana (mau manawa 17.5) i ka hoʻohālikelikeʻia me nā Viagra a me Levitra (4-5 hola). ʻO kēia lōʻihi o ka hana ola ma kahi lōʻihi o ka hana aʻo ia, ma ka hapa, ke kuleana o ka inoa Cialis o ka "pill weekend".ʻO kēia ka hapalua o ke ola ka kumu o ka hoʻokolokolo 'ana i kēia manawa no ka hoʻohanaʻana o ka tadalafil ma ka pulveary hypertension hypertension i hoʻokahi lā o ka hanaʻana.

Ka hana hana

Hanaʻia ka Penile no ka hoʻouluʻana i ka wahine ma ka hoʻomahaʻana o nā penetere penile a me nā mīkini paʻakikī koʻikoʻi, kahi e hoʻonui ai i ke koko i ke kola. ʻO kēia hoʻomaha e hiki ai ke hoʻonuiʻia ke kahe o ke koko ma nā piho penile,ʻoiai ke koko e piha i nā keʻenaʻelua i loko o ka peni i kapaʻia ka cavernosa corpora. I ka pihaʻana o nā keʻena i ke koko, ua ulu ke peni. Hoʻolālāʻia ka hopena i ka wā e holo ai nā mele a me nā koko i loaʻa i loko o nā'elemeni penile.

Hoʻopili ʻia kēia pane e ka hoʻokuʻu ʻana o ka nitric oxide (NO) mai nā nū o nā nerve a me nā ʻāpana endothelial, ka mea e hoʻoulu ai i ke kāpili ʻana o ka cGMP i nā sela musle o nā peʻupena a laila hoʻomalu i ka hoʻopio ʻana a me ka hōʻemi o nā moku koko e lawe ana i ke koko a mai ka ʻalī. Hoʻokomo ʻo Cyclic GMP i ka hoʻomaha ʻana o ka naʻau a hoʻolōʻihi i ka kahe koko i loko o ka cavernosum corpus, a hoʻohenaheʻe ʻia e ka codyx spesial codyx 5 (PDE5) i ka corpus cavernosum e kokoke ana i ka penis. Hoʻopili ʻo Tadalafil i ka PDE5 a laila e hoʻonui i ka hoʻonui ʻana o ka nui cGMP i loaʻa. Ke hooki nei ʻo Tadalafil i ka PDE5 mai ka luku ʻana i ka cGMP a laila hoʻonui i ka cGMP i loaʻa i hiki ai ke hoʻokō i ka hana a hoʻomālamalama i ka neʻe ʻana i nā lā hou aku.

Akā, no ka liʻiliʻi loa o ka hapalua o ke ola o Tadalafil,ʻo ka hopena i loaʻa i ka holo o 2 lā e hana ai i ka PDE5 e hoʻi mai me kou ola kino - eʻoi aku kaʻino. Ponoʻoe e lōʻihi i ka hopena e loaʻa ai ka hopena āu e makemake ai, e like me ka hikiʻana o Cialis 4-5 mau lā ikaika no nā lā 4-5.

noi

  • Ke hoʻololi o Erectile (ED)
  • ʻO ka pulupuna maʻamau
  • ʻO ka hyperplasia hōʻino haʻahaʻa
  • ʻO'Akela
  • Norepinepine kiʻi
  • ʻO ka Muonipipipiponona'Olohe

Hōʻoiaʻia kaʻikeʻana o kaʻala Tadalafil

Hiki i nā kāleʻele, nā'ōmele a me nā'āpana almond i nā kiʻi polima a 5, 10 a me 20 milligram (mg). ʻO ka lālani hoʻomaka o Cialis kalo no ka hoʻohanaʻana i ka mea nui i ka hapanui o nā maʻi,ʻo ia ka 10 mg, i laweʻia ma mua o ka hana maʻamau.

ʻO ka lālani mua he 10 milligrams (mg) ma lalo o 30 mau minuke ma mua o ka hana maʻamau. Hiki ke hoʻonui i ka hōʻailona i ka 20 mg a i emi iho i ka 5 mg, ma muli o ka pono a me ka palekana o kēlā me kēia kanaka. Akā,ʻo ka mea kiʻekiʻe loa he 20 mg e like me kahi helu hoʻokahi. ʻO ka laulima pākuʻiʻoiʻia i hoʻokahi lā no ka lā ma ka nui o nā maʻi. ʻaʻole pono e lawe i hoʻokahi manawa aʻe i hoʻokahi manawa i nā hola 24. ʻO nā maʻi e manaʻo nei e hana i ka moekolohe ma kahi oʻelua manawa i ka hebedoma, e hiki ke lawe i nā lā o ka 5 mg, a hoʻemiʻia kēia i ka 2.5 mg i kēlā me kēia lā, e like me ka manaʻo o kēlā me kēia.

ʻO ka pauku Cialis no ka hoʻohana e like me ka mea i hōʻike ʻia e hoʻomaikaʻi i ka hana hoʻohālikelike i ka placebo a hiki i nā hola 36 ma hope o ka pau ʻana. No laila, i ke aʻo ʻana i nā maʻi i ka hoʻohana pono ʻana i ka paupa Cialis, pono e noʻonoʻo ʻia.

ʻAʻole ia he mea kūpono ia e hele mai kahi neʻe ʻana ma ka lawe wale ʻana i kahi pōpoki. A mai lawe ʻoe i Cialis no ka disfunction inā ʻoe e lawe ana i ka Adcirca no ka hypertension arterial pulmonary. Ma kahi aʻe, ʻo Tadalafil no ka hana kuhi wale nō ka hoʻohana ʻia e nā pākeke ʻo 18 mau makahiki a ma luna.

maika

♦ E hiki i ka palolo kala ke kōkua i ka hoʻomaha i ka maʻi i loko o kou maʻi prostate a me ke kiko. Hiki iā ia ke kōkua i ka hoʻoikaikaʻana i kāu mau hōʻike BPH.

♦ E hoʻonui i nā hōʻailona ED, hiki i ka palolo kālaki ke kōkua i ka hoʻonuiʻana i ke koko i ka peni. Hiki iā ia ke kōkua iāʻoe e loaʻa a mālama i kahi kūkulu. No kaʻala pale e kōkua iāʻoe e kūkulu i kūkulu, ponoʻoe e hoʻonā i ka wahine.

♦ No ka PAH, hana kaʻopihi tadalafil i mea e hoʻomaikaʻi ai i kou hiki ke hana i ka hoʻonaneaʻana i nā kīʻaha koko ma kou mau māmā. Hoʻonui kēia i ke koko.

Nā hopenaʻaoʻao

A me nā hopena e pono ai, hiki i kekahi lāʻau lapaʻau ke hana i kekahi mau mea i makemakeʻoleʻia. ʻOiaiʻaʻole hiki ke loaʻa i kēia mau hopena a pau, inā hana lākou e pono ai lākou i ke olakino. Eʻoluʻolu e hoʻokaʻawale i nā hopena o hope o ka hoʻopunipuniʻana:

Nā hopena piliʻaoʻao

▪ i ke poʻo

▪ ka huhū huhū

▪ kaʻeha hou

▪ nā maʻiʻeleʻele

▪ ka'ōwili ('iliʻula)

▪ kuʻi a ihu ka ihu

▪ ka maʻiʻana

Nā hopena paʻakikī a iʻole ka hopena

ʻO kahi hoʻolālā lōʻihi e hiki ai ke hōʻeha i ka peni, nā pilikia pilikino, a me ka pohō pepeiao.

Inā mālie kēia mau mea, hiki iā lākou ke hele i loko o kekahi mau lā heʻelua mau pule. Ināʻoi aku kaʻino aʻoiʻole paha, e kamaʻilio me kāu kauka a mea kauka.

ʻO nā kānaka me nā kūlana i lalo,ʻaʻole lākou e lawe i kaʻaila Cialis keʻole kahi kauka eʻaeʻia:

Nā pilikia o ka naʻau, angina, a me kēlāʻanoʻano maʻi o ka maʻi

ʻO ke aniamaha kiʻekiʻe

ʻO ka'ōpū o ka naʻau aʻoleʻa paha i loko o nā mahina 6 i hala iho nei, a iʻole kaʻeke'ekeocona i loko o nā mahina 3 hope loa

ʻO ka anemia sickle, ka mieloma nui, ka hemophilia, leukemia, a me kekahi maʻi maʻi'ē aʻe

Ka maʻi hōʻoeʻe a maʻi maʻi paha

ʻO ka maʻi ulcer

ʻO ka Retentitis pigmentosa

ʻO ke kūpopo o ka penisona, e like me ka maʻi o Peyronie

ʻO kēlā me kēiaʻano olakino i'ōleloʻia aiʻaʻole lākou e moe

ʻO ka hulina Tadalafil

Ke hoʻohanaʻoe i ka huapalapala, hiki i kekahi mau lāʻau lapaʻau e hiki ke hoʻopili i ka lāʻau lapaʻau, a hiki i nā hopenaʻaoʻao. Hiki ke hoʻololi i ka pilina o nā lāʻau kino i ka hanaʻana o kāu mau lāʻau aiʻole e hoʻonui i kou pilikia no nā hopena koʻikoʻi.

Hiki i kahi a Tadalafil ke hoʻoikaika i ka hopena o ke koko. Hiki i ka Tadalafil ke hoʻoulu i kahi kaumaha nui o ke kahe o ke koko ke hoʻohanaʻia me ka nitrates, a hiki ke alakaʻi i ka nūniki, kūpilikiʻi, a me ka maʻiʻole o ka'ōpū. Mai hoʻohanaʻoe i kahi kāpili me kekahi o kēia mau mea: kekahi mau lāʻau lapaʻau i hoʻohanaʻia no ka mālamaʻana i kaʻeha a me ka angina (nitrates e like me nitroglycerin, isosorbide), nā mea hōʻoluʻolu i kapaʻia "poppers" me ka amyl a me ka buty nitrite.

Ināʻoe e lawe i kahi lāʻau pilikino alpha (e like me doxazosin, tamsulosin) e mālama i ka prostate / BPH nui a iʻole ke koko kiʻekiʻe, hiki ke kaumaha loa i ke kahe o ke koko e hiki ai ke alakaʻi i ka noʻonoʻo a iʻole ka nāwaliwali. Hiki i kāu kauka ke hoʻomaka i ka hoʻomaluʻana me ka hapa liʻiliʻi o nā huapalapala a iʻole e hoʻoponopono i kāu lāʻau ākea alpha bloining e hōʻemi i ka hopena o ke kalapona haʻahaʻa.

Ma nā haʻawina loea, ua hōʻike ʻia nā kumukūʻai nui o ka pane a hiki i ka 36 h ma hope o ka hoʻonā lāʻau ʻana. Ka nui o ka Tadalafil i ka nui o ka pūpū e CYP3A4 i nā kino mea ʻaʻole i ikaika e kū'ē i PDE5 a hoʻopuka nui ʻia e like me nā metabolites i nā feces a me nā urine. ʻO ka pharmacokinetics o tadalafil i hoʻopilikia ʻia e nā mea e like me ke kaʻai ʻana i ka meaʻai a me ka waiʻona, ka makahiki, ka hele ʻana o ka maʻi maʻi maʻi, a me nā maʻi hepatic maʻalahi. ʻO nā hanana hōʻino pinepine e pili pono ana i nā hōʻeha o ka poʻo, ke ʻeha, ka dyspepsia, a me ka myalgia. I 10 a me 20 mg dosis, ʻaʻole ia i nui o Tadalafil i ka hopena o ke koko a me ka puʻuwai puʻuwai a ʻaʻole i hopena i ka nui o ka manawa o ka infionction myocardial. Ua hōʻike ʻia nā hōʻike līlī e pili ana i nā kikowaena lōʻihi ma mua o 4 h a me ka priapism me ka hoʻohana ʻana o tadalafil. ʻO ka Priapism, inā ʻaʻole kūpono ke mālama ʻia, hiki ke hopena i ka hōʻino ʻole ʻana i ka mahele. ʻAe ʻia nā mea maʻi e loaʻa ana i kahi kūkulu ma mua o 4 h e ʻimi i ka mālama olakino pōpilikia. I nā poʻe maʻi maʻi maʻi, ʻo ka hoʻonui ʻana o ka hana e tadalafil i kūlike ʻole i ka ʻano o ka maʻi maʻi a me ke ʻano o ka maʻi maʻi maʻi.

Hiki i nā lāʻau'ē aʻe ke hoʻopili i ka weheʻana o nā hua'ōlelo mai kou kino mai, aʻo ia hoʻi ka hopena o ka hanaʻana o ka papa. Ano he kumu hoʻohālike nā HI antifungals (e like me itraconazole, ketoconazole), macrolide antibiotics (e like me clarithromycin, erythromycin), HIV protease nā mea kūpale (e like me fosamprenavir, ritonavir), hepatitis C mea hoʻomaʻi protease nā mea kūpale (e like me boceprevir, telaprevir), rifampin, i waena o 'ē aʻe .

Mai lawe i kēia lāʻau lapaʻau me nā huahana ʻē aʻe e loaʻa ana ka tadalafil a i ʻole nā ​​lāʻau like ʻole e hoʻohana ʻia e mālama ai i ka dysfunction-ED a i ʻole hypertension pulmonary (e like me sildenafil, vardenafil).

No ka hoʻohanaʻana i ka lāʻau me nā lāʻau'ē aʻe, nui ka nui, inā makemakeʻoe e hoʻohana i kekahi lāʻau lapaʻau me ka paona tadalafil (CAS 171596-29-5), e hoʻomanaʻo mua e nīnau i kāu kauka a hāʻawiʻo ia iāʻoe i kaʻoihana koʻikoʻi.

Nāʻike'ē aʻe

ʻO ka māmāʻo Tadalafil, ka puehu sildenafil, a me ka lepo o nā mea e hana ai ma ka hanaʻana i ka enzyme PDE5, akāʻo kēia mau lāʻau lapaʻau pū kekahi i ka enzymes PDN 6, 1, a me 11 ma nāʻano likeʻole. Eia kekahi laʻana,ʻo Sildenafil a me ka wehewehe i ka PDE6, he enzyme i loaʻa i ka maka,ʻoi aku ma mua o ka tadalafil. Hiki i kekahi poʻe nānā ke nānā aku i kahi kālepa bluish a loaʻa i ke kūlana kiʻekiʻe i ka mālamalama no ka PDE6 inhibition. Ma waho aʻe,ʻo Sildenafil a me ka mea hoʻonāukiuki e kāohi i ka PDE1 ma mua aʻe o ka papa. Aia ka PDE1 i loko o ka lolo, ka naʻau, a me ka puʻupuʻu mālie. Ke manaʻoʻiaʻo ka hanaʻole o PDE1 e ka sildenafil a me ka vardenafil e alakaʻi aku ai i ka vasodilation, kaʻimiʻana, a me ke tachycardia.

I hoʻohālikelikeʻia i ka hana ma PDE6 a me PDE1, uaʻoi aku ka mahalo nui o ka hua'ōlelo ma PDE11. Hōʻikeʻia ka PDE11 i loko o kaʻeleʻeleʻeleʻele, ka prostate, ke ake, a me ke kīnaʻi, ka pituitary gland, a me nā hōʻailona. Eia naʻe,ʻaʻoleʻikeʻia nā hopena ma ke kino o ka pāpāluaʻana i PDE11.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.


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Nāʻike & nā hua'ōlelo huahana

E hoʻomaopopo '

  • 1.National Center no kaʻikeʻenehana Biology, US. Ka Waihona Puke o ka Hale Waihona Puke, Tadalafil, Pubchem Makahiki 1-10.
  • 2.Evelyn C. Cortez, CIALIS (Tadalafil): Nā hoʻohana, ka hana, nāʻikeʻikeʻaoʻao a me kahi e kūʻai ai i Genial Cialis (Tadalafil), Viagra (Sildenafil), a me nā mea maikaʻi'ē aʻe me ka wikiwiki pūnaewele, i hoʻopukaʻia, 13 Dec 2017,ʻaoʻao 5-3
  • 3.James Lee Anderson, Cialis, Tadalafil: Hana i kahi'ālohelohe o ke kino, Symptoms of Hydrophonic Prostatic Hypothesis, and Hydrotension Arthritis, CreateSpace Independent Publishing Platform, 26 Mar 2015,ʻaoʻaoʻo 5-47.

ʻO Shangke Chemical he polokalamu kelehana kiʻekiʻe e kū nei i nā mea hana hana hoʻopihamaha hana (APIs). No ka mālamaʻana i ka maikaʻi i ka manawa o ka hanaʻana, kahi nui o nāʻoihana akamai, nā mea hana papa hana mua a me nā hale liʻiliʻi i nā kumu nui.

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