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Oleoylethanolamide (OEA) (111-58-0)

ʻO Oleoylethanolamide (OEA) kahi agogist progiferator peroxisome-activated alpha (PPAR-alpha) agonist. He He …… ..


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

Description

Oleoylethanolamide (OEA) (111-58-0) Nā kuʻina

Product Name Oleoylethanolamide (OEA)
Hawaiian Name n-oleoylethanolamine; N- (2-Hydroxyethyl) oleamide; Oleylethanolamide;

N-oleoyl ethanolamine; Oleamide MEA; Oleoyl monoethanolamide;

Oleoyl Ethanolamide;

Kāleka CAS 111-58-0
InChIKey BOWVQLFMWHZBEF-KTKRTIGZSA-N
SMILE CCCCCCCCC = CCCCCCCCC (= O) NCCO
Ka Lā Molecular C20H39NO2
Molecular Weight 325.5 g / mole
Monoisotopic Mass 325.537 g · mol-1
Point Hoʻolālā 59-60 ° C (138 – 140 ° F; 332-333 K)
ʻO Boiling Point 496.4 ± 38.0 ° C (Manaʻo ʻia)
nuʻa 0.915 ± 0.06 g / cm3 (Puhi ʻia)
kala like 'ole Keʻokeʻo
Shoʻoweliweli temp -20 ° C
Mālama i ka ethanol a me DMSO Hoʻololiʻia
noi Palapala phamaceutical; hoʻouka;

He aha ka Oleoylethanolamide (OEA)?

ʻO Oleoylethanolamide (OEA) kahi agogist progiferator peroxisome-activated alpha (PPAR-alpha) agonist. ʻO ia he kūlohelohe glycolamide lipid me ka ʻano o nā ʻano homeostasis kūʻokoʻa e like me ka makemake o ka makemake, ka hana anti-inflammatory, ka hoʻoulu ʻana i ka lipolysis me ka momona o ka hoʻōho momona. Hiki ke manaʻo ʻia ʻo Oleoylethanolamide he hormone o ke aʻa o ka ʻōpū o ka ʻōpū. ʻO ka oatmeal, nā nati, a me ka pauku koko ka puna nui nā kumu o Oleoylethanolamide i nā meaʻai. Akā, ʻo ka nui o Oleoylethanolamide i loaʻa i kēia mau meaʻai he haʻahaʻa (ʻoi aku ma mua o 2 µg / g).

Ma ke ʻano he lipid active biidically olidlethanolamide (OEA) i loko o ka ʻōpū a me nā ʻano ʻili, a ua kau ʻia i nā hoʻoponopono kōpaʻa o ka ikehu o ka molmalian, hoʻoponopono i ka lawelawe o ka meaʻai a me ka molake molid, e like me ia ka mea e hoʻoponopono i ka meaʻai ʻo Vertebrate a me ke kaumaha o ke kino. ʻO Oleoylethanolamide kahi fatty acid ethanolamide (FAE), kahi monounsaturated analog o endocannabinoid arachidonic acid ethanolamide (anandamide), a me kahi hana anagonide hoʻoikaika. He mea pono ia e ʻokoʻa i ka mana o Oleoylethanolamide mai anandamide, kūʻokoʻa ia i ka mea hoʻokipa cannabinoid, a hana i kāna hana bioloola ma o nā ala ʻē aʻe, e hoʻoponopono ana i ka hana PPAR-α e hoʻoulu ai i ka lipolysis. ʻO Oleoylethanolamide kahi kūpono a palekana palekana anti-obesity i mea e hoʻohuli ai i ka antagonism CB1.

Ua hōʻike ʻia nā haʻawina preclinical ʻo Oleoylethanolamide kahi maikaʻi anti-inflammatory a me ka antioxidant pūlea e hōʻeuʻeu aku i nā hopena neuroprotective ma ka ʻalā. Hiki i ka hoʻokele Exogenous o Oleoylethanolamide hiki ke pale aku i ka hōʻino o ka wai lālau ʻana o ka TLR4-mediated citrex aine o ka wai, a laila hoʻēmi i ka hoʻokuʻu ʻana o nā cytokine proinflamerian a me ka chemokines, oxidative a me ka nitrosative stress, a hiki i ka pale mua i ka hoʻopilikia kino i ka cortex frontal o nā rodents.

He aha ka hana a Oleoylethanolamide (OEA) e hana?

I ka poʻe momona, hiki i ka OEA ke hoʻoponopono i ka homeostasis ikaika a me ka makemake nui ma o ka hoʻōla ʻana o nā mea ʻae like ʻole me ka proliferator proliferator-activated receptor-α (PPAR-α), G-protein-Coupled receptor 119 (GPR119) a me ka transient receptor potation cation channel subfamily V (TRPV1). ʻOiaʻiʻo, hoʻomohala ʻo OEA i kēia mau mea nānā aku a hoʻohemo i ka hoʻomaka ʻana o ka papaʻaina, e hōʻemi ana i ka nui o ka pāʻina, a hoʻoneʻe i nā kikowaena ma waena o ka papaʻaina a no ka hoʻololi ʻana i ke kaumaha kino.

A, kekahi mau hoʻokolohua hoʻokolohua hōʻike ʻia e paʻa ana ka OEA i ka hōʻike o IL-6, interleukin-8 (IL-8), molekui interhesular molina-1 (ICAM-1) a me ka molopole adhesion cell vascular-1 (VCAM-1) i ka TNF -a me ka hoʻowalewale i ke kani ʻana i nā pona endothelial i ka umbilical urina ma o ka hoʻōla ʻana o nā ʻili. Ua kāpili ʻo OEA i ke ala o ke ala neo kappa-B (NF-kB) i ke ala. Ma ka hōʻike ʻo YT et al, ua hoʻokuʻu aku ʻo OEA (50 µmol / L) i ka hōʻike o TNF-α i loaʻa ai ka hōʻike VCAM-1 ma HUVEC.

ʻO nā pono o Oleoylethanolamide (OEA)

Ma kahi o ka ceramidase inhibitor, he agonist endogenous o ka mea hoʻokipa GPR119, ʻo Oleoylethanolamide e kūleʻa ana i nā maʻi neurodegenerative, anti-atherosclerosis, apoptosis, hōʻeha hōʻeha, hoʻonaninani i ka lipid metabolism, a me nā ʻenue ma nā islet is nā pū. ʻO ka pale a me nā maʻi metabolic kahi maikaʻi e pale ai. Eia kekahi, hiki iā ia ke hōʻemi i ka momona o ke kino ma o ka kaohi ʻana i ka mea momona, hoʻokaumaha momona, a hoʻokō i nā momona kaumaha. Ua hiki iā Oleoylethanolamide ke kuleana no ka hōʻemi ʻana i ka mumū a hoʻohaʻahaʻa i nā pae cholesterol.

ʻO nā hoʻohana o Oleoylethanolamide (OEA)

  • Palapala phamaceutical Hoʻohui kumuwaiwai
  • Gaetani S, Oveisi F, Piomelli D (2003). "Ka lihalihi ʻana o ka pāʻina ʻai i ka iole e ka anorexic lipid mediator oleoylethanolamine". Neuropsychopharmacology. 28 (7): 1311–6. doi: 10.1038 / sj.npp.1300166. PMID 12700681.
  • Lo Verme J, Gaetani S, Fu J, Oveisi F, Burton K, Piomelli D (2005). "Hoʻoponopono i ka ʻai ʻana ma ka oleoylethanolamine". Pūnaewele. Mol. Life Sci. 62 (6): 708–16. doi: 10.1007 / s00018-004-4494-0. PMID 15770421.
  • Giuseppe Astarita; Bryan C. Rourke; Johnnie B. Andersen; Jin Fu; Janet H. Kim; Albert F. Bennett; James W. Hicks & Daniele Piomelli (2005-12-22). "ʻO ka hoʻonui ʻana o ka hoʻihoʻi ole o ka oleoylethanolamine i loko o kahi pākahi liʻiliʻi o ka Python Burmese (Python molurus)". Am J Physiol Regul Integr Comp Physiol. 290 (5): R1407 – R1412. doi: 10.1152 / ajpregu.00664.2005. PMID 16373434.
  • Gaetani S, Kaye WH, Cuomo V, Piomelli D (September 2008). "Ka mana o ka endocannabinoids a me kā lākou analogues i ka lesity a me ka ʻai ʻana i ka maʻi." ʻAi Hoʻohui Paʻa. 13 (3): e42–8. PMID 19011363.
  • Serrano A, et al. Oleoylethanolamide: hopena i ka hoʻopili hypothalamic a me ka peptides o ke kao e hoʻoponopono ai i ka hoʻopono o ka meaʻai. Neuropharmacology. (2011)

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