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Paʻakai disodium NADP (24292-60-2)

ʻO Nicotinamide adenine dinucleotide phosphate (NADP +) he cofactor i hoʻohana i loko o nā hopena anabolic. β -kino…


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

Description

β-Nicotinamide adenine dinucleotide phosphate disodium salt (NADP disodium salt) Snāʻike

Product Name β-Nicotinamide adenine dinucleotide phosphate disodium salt (NADP disodium salt)
Hawaiian Name Nahuika NADP; Disidium Nadide phosphate; NADP; β-NADP; ʻO ka paʻakai disodium o Triphosphopyridine;
Kāleka CAS 24292-60-2
InChIKey UNRRSQIQTVFDLS-WUEGHLCSSA-L
SMILE C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+]
Ka Lā Molecular C21H26N7Na2O17P3
Molecular Weight 787.37
Monoisotopic Mass 787.039342 g / mole
Point Hoʻolālā 175-178 ° C
kala like 'ole Melemele
Shoʻoweliweli temp -20 ° C
ka wai Palekana > 50 g / L
noi Coenzyme i loko o kahi aerobic a anaerobic

He aha ia ʻo β-Nicotinamide adenine dinucleotide phosphate disodium salt (NADP disodium salt)?

ʻO Nicotinamide adenine dinucleotide phosphate (NADP +) he cofactor i hoʻohana i loko o nā hopena anabolic. β-Nicotinamide adenine dinucleotide phosphate disodium salt he disodium paʻakai o NADP +, he coenzyme pono no ka hoʻonaninani kūlohelohe o ka glucose a me ka hoʻoiho oxidative o nā mea ʻē aʻe. A loaʻa nui ia i ka ola ola, ʻoi loa i ka puʻuwai.

ʻO Nicotinamide adenine dinucleotide phosphate (NADP) a me NADPH i hana i kahi kapa redox. Hoʻonohonoho ka pauna o ka NADPH / NADP i ka mana redox intracellular, ka nui aʻe o ka pane anaerobic, ma laila e hoʻopiʻi ai i ka pane o ka metabola i loko o ke kino. ʻO nā hiʻohiʻona he mau lehelehe lipid a me ka nucleic acid. ʻO ka NADP kahi pālua coenzyme i loko o nā ʻōnaehana cytochrome P450 a me nā ʻōnaehana reaksi oxidase / reductase e like me ka thioredoxin reductase / thioredoxin pūnaehana.

Hāʻawi ka NADPH i ka hoʻokaʻawale ʻana i nā kūmole i ka hopena biosynthetic a hāʻawi i nā hopena redox e pale ai i ka pauku o nā oxygen oxygen react (ROS), a laila hana hou i ka glutathione (GSH). Hoʻohana ʻia ia i nā ala anabolic e like me kolesterol synthesis a me nā momona fatty Chain extension.

Eia kekahi, pono pū ka ʻōnaehana o NADPH no ka hoʻopuka ʻana i nā mea hōʻoloʻalapa manuahi i nā maʻi kūlohelohe ma o NADPH oxidase. Hoʻohana kēia mau radical manuahi e hoʻopau i nā pathogens i kahi hana i kapa ʻia ʻo ka hanu. He hōʻemi ia i nā kūlike o ka puna cytochrome P450 hydroxylated aromatics, steroid, alcohols, a me nā mea lapaʻau.

noi o β-Nicotinamide adenine dinucleotide phosphate disodium salt

ʻO Nicotinamide adenine dinucleotide phosphate (NADP) a me NADPH i hana i kahi kapa redox. ʻO ka NADP / NADPH kahi mea coenzyme e kākoʻo ana i ka hoʻoneʻe redox ma o ka lawe ʻana i nā electrons i ka nui o nā noi, ʻoiai ka hopena anaerobic e like me ka lipid a me ka nucleine acid synthesis. ʻO ka NADP / NADPH he mau mea coenzyme i loko o nā ʻōnaehana cytochrome P450 a me nā ʻōnaehana hoʻoneʻe oxidase / reductase, e like me ka ʻōnaehana thioredoxin reductase / thioredoxin.

ʻO nā hui ʻē aʻe e hoʻohana ai i ka NADP e like me ka coenzyme:: Dehydrogenase alcohol: NADP hilinaʻi; Hoʻohuukui ADH: NADP hilinaʻi; Ferredoxin-NADP hoʻōla; L-Fucose dehydrogenase; Gabase; Kahiliʻili-Galactose-1-phosphate uridyl; Hoʻolaha ka hanu Glucose; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP kiko; kiko; Hoʻopaʻa Isocitric i lalo; Nā ʻōkuhi Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase a me Succinic semialdehyde dehydrogenase.

Reference:

  • ʻO Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism e hoʻomoʻi nei i ka hoʻomālamalama mālamalama NADP Dynamics i nā mea kanu. Mua Kāne Sci. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
  • Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. The toxerkulosis necrotizing toxin is a NAD + a me NADP + glycohydrolase me nā ʻokoʻa kūmole o ka enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
  • Liang J, Huang H, Wang S. Distribution, E evolution, Catalytic Mechanism, a me Ph Phnological Functiontions a Flavin-based Electron-Bifurcating NADH-Dependent Hoʻemi Ferredoxin: NADP + Oxidoreductase. Front Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
  • Kawai S, Murata K. "Kahiana a me ka hana o ke kinAD Nase kinase a me ka phosphatase NADP: nā kīnū koʻikoʻi e hoʻoponopono i ka pale o ka intracellular o NAD (H) a me NADP (H)". Nā Palepale, Biotechnology, a me Biochemistry. 72 (4): 919–30. doi: 10.1271 / bbb.70738. PMID 18391451.
  • Hanukoglu I. "Mālama o ka launa ʻo Enzyme-Coenzyme i FAD a me ka ʻAla Hoʻohui Aʻo Aododoxin Hoʻohālikelike-A Ubiquitous Enzyme". Ka Moʻolelo o ka Molecular Evolution. 85 (5–6): 205–218. Palapala kūhelu: 2017JMolE..85..205H. doi: 10.1007 / s00239-017-9821-9.PMID 29177972.

NA HALO A E HOOLAHA:

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