NADP disodium paʻakai (24292-60-2) wikiō
β-ʻO Nicotinamide adenine dinucleotide phosphate disodium paʻakai (NADP disodium paʻakai) Snāʻike
| Product Name | β-ʻO Nicotinamide adenine dinucleotide phosphate disodium paʻakai (NADP disodium paʻakai) |
| Hawaiian Name | Nahuika NADP; Disidium Nadide phosphate; NADP; β-NADP; ʻO ka paʻakai disodium o Triphosphopyridine; |
| Kāleka CAS | 24292-60-2 |
| InChIKey | UNRRSQIQTVFDLS-WUEGHLCSSA-L |
| SMILE | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)OP(=O)([O-])[O-])O)O)O)C(=O)N.[Na+].[Na+] |
| Ka Lā Molecular | C21H26N7Na2O17P3 |
| Molecular Weight | 787.37 |
| Monoisotopic Mass | 787.039342 g / mole |
| Point Hoʻolālā | 175-178 ° C |
| kala like 'ole | Melemele |
| Shoʻoweliweli temp | -20 ° C |
| ka wai Palekana | > 50 g / L |
| noi | Coenzyme i loko o kahi aerobic a anaerobic |
He aha ia ʻo β-Nicotinamide adenine dinucleotide phosphate disodium salt (NADP disodium salt)?
ʻO Nicotinamide adenine dinucleotide phosphate (NADP +) kahi cofactor i hoʻohana ʻia i nā hopena anabolic. β-ʻO Nicotinamide adenine dinucleotide phosphate disodium paʻakai kahi paʻakai disodium o NADP +, he coenzyme pono ia no ka fermentation ʻona o glucose a me ka dehydrogenation oxidative o nā mea ʻē aʻe. A kū ākea ia i nā mea ola, keu hoʻi i ke ake.
ʻO Nicotinamide adenine dinucleotide phosphate (NADP) a me NADPH i hana i kahi kapa redox. Hoʻonohonoho ka pauna o ka NADPH / NADP i ka mana redox intracellular, ka nui aʻe o ka pane anaerobic, ma laila e hoʻopiʻi ai i ka pane o ka metabola i loko o ke kino. ʻO nā hiʻohiʻona he mau lehelehe lipid a me ka nucleic acid. ʻO ka NADP kahi pālua coenzyme i loko o nā ʻōnaehana cytochrome P450 a me nā ʻōnaehana reaksi oxidase / reductase e like me ka thioredoxin reductase / thioredoxin pūnaehana.
Hāʻawi ka NADPH i ka hoʻokaʻawale ʻana i nā kūmole i ka hopena biosynthetic a hāʻawi i nā hopena redox e pale ai i ka pauku o nā oxygen oxygen react (ROS), a laila hana hou i ka glutathione (GSH). Hoʻohana ʻia ia i nā ala anabolic e like me kolesterol synthesis a me nā momona fatty Chain extension.
Eia kekahi, pono pū ka ʻōnaehana o NADPH no ka hoʻopuka ʻana i nā mea hōʻoloʻalapa manuahi i nā maʻi kūlohelohe ma o NADPH oxidase. Hoʻohana kēia mau radical manuahi e hoʻopau i nā pathogens i kahi hana i kapa ʻia ʻo ka hanu. He hōʻemi ia i nā kūlike o ka puna cytochrome P450 hydroxylated aromatics, steroid, alcohols, a me nā mea lapaʻau.
noi o β-Nicotinamide adenine dinucleotide phosphate disodium salt
ʻO Nicotinamide adenine dinucleotide phosphate (NADP) a me NADPH i hana i kahi kapa redox. ʻO ka NADP / NADPH kahi mea coenzyme e kākoʻo ana i ka hoʻoneʻe redox ma o ka lawe ʻana i nā electrons i ka nui o nā noi, ʻoiai ka hopena anaerobic e like me ka lipid a me ka nucleine acid synthesis. ʻO ka NADP / NADPH he mau mea coenzyme i loko o nā ʻōnaehana cytochrome P450 a me nā ʻōnaehana hoʻoneʻe oxidase / reductase, e like me ka ʻōnaehana thioredoxin reductase / thioredoxin.
ʻO nā hui ʻē aʻe e hoʻohana ai i ka NADP e like me ka coenzyme:: Dehydrogenase alcohol: NADP hilinaʻi; Hoʻohuukui ADH: NADP hilinaʻi; Ferredoxin-NADP hoʻōla; L-Fucose dehydrogenase; Gabase; Kahiliʻili-Galactose-1-phosphate uridyl; Hoʻolaha ka hanu Glucose; L-Glutamic dehydrogenase; Glycerol dehydrogenase: NADP kiko; kiko; Hoʻopaʻa Isocitric i lalo; Nā ʻōkuhi Malic; 5,10-Methylenetetrahydrofolate dehydrogenase; 6-Phosphogluconate dehydrogenase a me Succinic semialdehyde dehydrogenase.
Reference:
- ʻO Hashida SN, Kawai-Yamada M. Inter-Organelle NAD Metabolism e hoʻomoʻi nei i ka hoʻomālamalama mālamalama NADP Dynamics i nā mea kanu. Mua Kāne Sci. 2019 Jul 26; 10: 960. doi: 10.3389 / fpls.2019.00960. eCollection 2019. PMID: 31404160. PMCID: PMC6676473.
- Tak U, Vlach J, Garza-Garcia A, William D, Danilchanka O, de Carvalho LPS, Saad JS, Niederweis M. The toxerkulosis necrotizing toxin is a NAD + a me NADP + glycohydrolase me nā ʻokoʻa kūmole o ka enzymatic.J Biol Chem. 2019 Mar 1; 294 (9): 3024-3036. doi: 10.1074 / jbc.RA118.005832. Epub 2018 Dec 28. PMID: 30593509. PMCID: PMC6398120.
- Liang J, Huang H, Wang S. Distribution, E evolution, Catalytic Mechanism, a me Ph Phnological Functiontions a Flavin-based Electron-Bifurcating NADH-Dependent Hoʻemi Ferredoxin: NADP + Oxidoreductase. Front Microbiol. 2019 Mar 1; 10: 373. doi: 10.3389 / fmicb.2019.00373. eCollection 2019. PMID: 30881354. PMCID: PMC6405883.
- Kawai S, Murata K. "Ka hana a me ka hana o NAD kinase a me NADP phosphatase: nā enzyme kī e hoʻoponopono i ke kaulike intracellular o NAD (H) a me NADP (H)". ʻO Bioscience, Biotechnology, a me Biokimia. 72 (4): 919-30. hana: 10.1271 / bbb.70738. PMID 18391451.
- Hanukoglu I. "Ka mālama ʻana i ka Enzyme-Coenzyme Interfaces ma FAD a me NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme". Ka Nupepa o ka Molecular Evolution. 85 (5-6): 205-218. Bibcode: 2017JMolE..85..205H. hana: 10.1007 / s00239-017-9821-9.PMID 29177972.
