N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

March 11, 2020
SKU: 146-48-5

ʻO NACET (N-Acetylcysteine ​​ethyl ester) kahi mea pili i ka lipophilic cell-permeable cysteine ​​i loaʻa me kahi ʻano pharmacokinetic ʻokoʻa a kupaianaha ... ..

 


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

 

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) wikiō

NACET (59587-09-6) Nā kikoʻī

Product Name NACET OE-59587-09-6)
Hawaiian Name R) -ethyl 2-acetamido-3-mercreensropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
Kāleka CAS 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
Ka Lā Molecular C7H13NO3S
Molecular Weight 191.25
Monoisotopic Mass 191.061614 g / mole
Point Hoʻolālā 44.1-44.5 ° C
ʻO Boiling Point  337.6 ± 32.0 ° C (Manaʻo ʻia)
nuʻa 1.138 ± 0.06 g / cm3 (Puhi ʻia)
kala like 'ole Paʻa-keʻokeʻo
noi Hiki i nā Nootropics a me nā lāʻau lapaʻau akamai, no ka hoʻoulu ʻana i ka hoʻomanaʻo, ka hoʻokau ʻana, nā akamai, ka naʻauao a me ka manaʻo. Hiki nō hoʻi ke lilo i ka hoʻohui iʻa o kaʻai.

 

He aha NACETA(N-Acetylcysteine ​​ethyl ester)?

ʻO NACET (N-Acetylcysteine ​​ethyl ester) kahi mea pili i ka lipophilic cell-permeable cysteine ​​derivative me kahi ʻano pharmacokinetic ʻokoʻa a me kahi mana antioksant kupaianaha. He bioavailability waha kiʻekiʻe ʻo NACET. He antioxidant ikaika a waiwai ʻo ia o GSH, e pili ana i kāna waikawa N-acetyl -L ʻokoʻa me -cysteine ​​(NAC). ʻO ka NACET he pauka keʻokeʻo i ka mahana o ka lumi a maʻalahi hiki ke hoʻoheheʻe ʻia i ka wai a me nā mea hoʻoheheʻeolaola.

ʻO NAC kahi huaʻehā o ka cysteine. Mai ka 1970s, ua hoʻohana ʻia e mālama i ka poʻe maʻi me ka overdose acetaminophen a me nā maʻi neurological, a kūʻai ʻia i ke ʻano o ka lāʻau lapaʻau a me ka pono o ke koina. Hoʻohālikelike ʻia me NAC, ʻoi aku ka nui o ka lipophilicity a me ka maikaʻi o nā huahana pharmacological maikaʻi loa. Loaʻa ia i ke keaka i ka pharmacological NAC, e like me ka mole mucolytic, antioxidant, mea hoʻolako o GSH, paracetamol antidote, a me ka liʻiliʻi o Donor o ka gaseous transmitter H 2 S a me ka māka palekana UV.

Hoʻohui ʻia, ua hōʻoia ʻia ka ikaika o ka nucleophilicity a me ka hōʻemi ʻana i ka hiki o NACET i loko o nā hunaola ʻulaʻula kanaka. Ua ʻike ʻia e hōʻiliʻili ʻia i loko o nā hunaola ʻulaʻula o ke kanaka, e pale pono ana i nā ʻino oxidative i hoʻokumu ʻia e hydroperoxides. No laila, ʻoi aku ka mana o ka NACET ma ke ʻano anti-nitrite i hoʻokomo ʻia i kahi anti-anti-nitrite i ʻoi aku ma mua o ka NAC methemoglobinemia a me nā oxidants ikaika. Ua ʻike ʻia nā noiʻi ma nāʻiole i ka lawe ʻia ʻana o ka NACET ma mua o ka NAC ke hāʻawi ʻia ʻo NACET ma ka waha. Hiki iā ia ke komo i nā pūnaewele a hana i ka NAC a me ka cysteine, e hoʻonui ai i ka hydrogen sulfide (H (2) S) i ke kaapuni. He moho maikaʻi ia no ka hoʻohana waha ma ke ʻano he H (2) S mea hana,

 

Loaʻa nā pono o NACET (N-Acetylcysteine ​​ethyl ester)

Me ka antioxidant koʻikoʻi, loaʻa nā NACET he nui pono e pili ana i ke olakino o ke kanaka.

- Hoʻonui i nā kūlana olakino he nui a hoʻomaha i nā hōʻailona o nā maʻi noʻonoʻo;

- Hoʻomaʻo i nā overdosis acetaminophen, pale i nā puʻupaʻa a me ke akepaʻa;

- Hoʻonui i ka hana māmā e ka hōʻemi ʻana i ka mumū a me ka wāwahi ʻana i ka mucus, a laila e hōʻemi ai i nā maʻi hanu mau.

- Paipai i ke olakino lolo ma o ka hoʻoponopono ʻana i ka glutamate a me ka hoʻopiha ʻana i ka glutathione, hiki ke hoʻohana ʻia e mālama i nā maʻi e like me ka maʻi ʻo Alzheimer a me ka maʻi ʻo Parkinson;

- Hoʻonui i ka momona o nā kāne a me nā wahine

- Hiki ke hoʻomaikaʻi i ka hana pale i nā maʻi he nui, pale i ka hōʻino ʻana o ka oxidative i ka puʻuwai, a hoʻemi i ka makaʻi o ka maʻi puʻuwai.

- E hoʻokūpaʻa paha i ke kō kō ma o ka hōʻemi ʻana i ka mumū ma nā keena momona

 

ʻO ka pākaha o NAECT (N-Acetylcysteine ​​ethyl ester)

Ma muli o ka hōʻike ʻana o ka NACET i nā hopena maikaʻi loa i nā maʻi noʻonoʻo, nā maʻi hanu maʻi mau a me nā maʻi noʻonoʻo, hoʻohana pinepine ʻia ia ma ke ʻano he lāʻau lapaʻau a me nā mea hoʻopihapihaʻai e pale ai i ka lolo, hoʻomaikaʻi i ka hana noʻonoʻo a me ke kino, i mea e hoʻonui ai i ka hoʻomanaʻo, ka ʻike ʻana a me ka hana haʻuki.

 

Reference:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): a novel lipophilic cell-permeable cysteine ​​derivative me kahi hiʻohiʻona maʻamau ʻo pharmacokinetic a me kekahi mea hiki mai antioxidant. Pāpaʻa Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) a me nā lako N-acetyl-L-cysteine ​​etyl ester (NACET) -Ny moho hāmeʻa e pili ana i ka lāʻau lapaʻau me nā mea lapaʻau hoʻonaninani kūʻokoʻa no ka hoʻohana ʻana i ka waha ma mua he NO, H2S a me nā mea hāʻawi GSH e like me antioxidants: Nā hopena a me ka ʻike. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Review. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester as GSH enhancer in human primothelial cell: He hui hoʻohālikelike me nā lāʻau ʻē aʻe. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) a me N-acetyl-L-cysteine ​​ethyl ester (NACET) –Ny moho hāmeʻa e pili ana i ka lāʻau lapaʻau ʻia me nā mea lapaʻau hoʻonaninani kūʻokoʻa no ka hoʻohana ʻana i ka waha ma mua he NO, H2S a me nā mea hoʻolako GSH e like me antioxidants: Nā hopena a me ka ʻike. Ka Nūpepa o ka ʻAkahi Huila. Volume 8, Lahui 1, Pepeluali 2018, ʻApana 1-9.