N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6)

March 11, 2020
SKU: 146-48-5
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NACET (N-Acetylcysteine ​​ethyl ester) he puke lipophilic cell-permeable cysteine ​​derivative me kahi ʻano pharmacokinetic maʻamau a kupaianaha hoʻi… ..


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

N-Acetyl-L-cysteine ​​ethyl ester (NACET) (59587-09-6) wikiō

NACET (59587-09-6) Nā kikoʻī

Product Name NACET (59587-09-6)
Hawaiian Name R) -ethyl 2-acetamido-3-mercreensropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-ACETYL-L-CYSTEINE ETHYL ESTER;
ethyl (2R) -2-acetamido-3-sulfanylpropanoate;
L-Cysteine, N-acetyl-, ethyl ester;
N-Acetylcysteine ​​ethylester;
Kāleka CAS 59587-09-6
InChIKey MSMRAGNKRYVTCX-LURJTMIESA-N
SMILE CCOC (= O) C (CS) NC (= O) C
Ka Lā Molecular C7H13NO3S
Molecular Weight 191.25
Monoisotopic Mass 191.061614 g / mole
Point Hoʻolālā 44.1-44.5 ° C
ʻO Boiling Point 337.6 ± 32.0 ° C (Manaʻo ʻia)
nuʻa 1.138 ± 0.06 g / cm3 (Puhi ʻia)
kala like 'ole Paʻa-keʻokeʻo
noi Hiki i nā Nootropics a me nā lāʻau lapaʻau akamai, no ka hoʻoulu ʻana i ka hoʻomanaʻo, ka hoʻokau ʻana, nā akamai, ka naʻauao a me ka manaʻo. Hiki nō hoʻi ke lilo i ka hoʻohui iʻa o kaʻai.

He aha NACET(N-Acetylcysteine ​​ethyl ester)?

ʻO NACET (N-Acetylcysteine ​​ethyl ester) he puke lipophilic cell-permeable cysteine ​​derivative me kahi ʻano pharmacokinetic ʻokoʻa a me ka mana antioxidant kupaianaha. He nui nā bioavailability o ka waha. He mau antioxidant ikaika a me ka waiwai nui o GSH, ka mea i pili me kāna free acid N-acetyl -L ʻokoʻa i ka -cysteine ​​(NAC). ʻO ka NACET kahi paule keʻokeʻo ma ke ana o ka lumi a hoʻohuihui kūwaho ʻia i ka wai a me nā wai kūlohelohe.

ʻO NAC kahi huaʻehā o ka cysteine. Mai ka 1970s, ua hoʻohana ʻia e mālama i ka poʻe maʻi me ka overdose acetaminophen a me nā maʻi neurological, a kūʻai ʻia i ke ʻano o ka lāʻau lapaʻau a me ka pono o ke koina. Hoʻohālikelike ʻia me NAC, ʻoi aku ka nui o ka lipophilicity a me ka maikaʻi o nā huahana pharmacological maikaʻi loa. Loaʻa ia i ke keaka i ka pharmacological NAC, e like me ka mole mucolytic, antioxidant, mea hoʻolako o GSH, paracetamol antidote, a me ka liʻiliʻi o Donor o ka gaseous transmitter H 2 S a me ka māka palekana UV.

Eia kekahi, ua hōʻoiaʻiʻo ʻia i nā nucleophilicity ikaika a hōʻemi i ka hiki ke NACET i loko o nā ʻāpana koko ʻōwili o kānaka. Ua loaʻa ʻia kahi hōʻiliʻili i loko o nā kōlepa koko o ke kanaka, e pale kūleʻa ana i ka pōʻino oxidative i kumu ʻia e ka hydroperoxides. No laila, ʻo ka hiki o ka NACET he antioxidant anti-nitrite-induced, ʻoi aku ka nui ma mua o ka nac methemoglobinemia a me nā oxidants ikaika. ʻIke ʻia nā haʻawina ma nā mea nui i ka hoʻouka ʻia ʻo NACET me ka wikiwiki ma mua o ka NAC i ka manawa e lawelawe ʻia ai ka NACET. Hiki iā ia ke komo i nā wahī a hoʻopuka i ka NAC a me ka cysteine, e hoʻonui ana i ka hydrogen sulfide (H (2) S) i ka kaila. ʻO ia ka mea koho maikaʻi no ka hoʻohana waha ma ke ʻano he mea hoʻohana (H) 2.

Loaʻa nā pono o NACET (N-Acetylcysteine ​​ethyl ester)

Me ka antioxidant koʻikoʻi, loaʻa nā NACET he nui pono e pili ana i ke olakino o ke kanaka.

- Hoʻonui i nā kūlana olakino lehulehu a hōʻoluʻolu i nā hōʻailona o ka maʻi noʻonoʻo;

- Ke hoʻomaʻamaʻa ʻana o nā overdoses acetaminophen, pale i nā ʻeha a me nā ate;

- Hoʻomaikaʻi i ka hana pūpū me ka hoʻohaʻahaʻa ʻana i ke aʻa a me ka wawahi ʻana i nā lemus, e hōʻoluʻolu ʻia i nā maʻi ʻeha.

- Paipai i ka olakino olakino ma o ka hoʻoponopono ʻana i ka glutamate a me ka hoʻopiha i ka glutathione, hiki ke hoʻohana i ka maʻi e like me nā maʻi a Alzheimer a me nā maʻi Parkinson;

- Hoʻonui i ka ulu maluhia i nā kāne a me nā wahine

- Hiki i ka hoʻomaikaʻi ʻana i ka hana palekana i nā maʻi he nui, e pale i ka hōʻeha o ka oxidative i ka puʻuwai, a e hōʻemi hoʻi i ka maʻi o ka naʻau.

- Hiki ke hoʻomau i ke kōhi koko ma ka hōʻemi ʻana i ka hōʻeha ʻana i nā momona momona

ʻO ka pākaha o NAECT (N-Acetylcysteine ​​ethyl ester)

No ka mea ua hōʻike ʻo NACET i nā hopena maikaʻi loa i ka maʻi noʻonoʻo, ke ʻano hanu o ka maʻi a me ka maʻi noʻonoʻo, hoʻohana pinepine ʻia ʻo ia i ka lāʻau a me ka papaʻai no ka mālama ʻana i ka lolo, hoʻomaikaʻi i ka noʻonoʻo ʻana a me ka hana kino, no laila e hoʻomaikaʻi ai i ka hoʻomanaʻo, ka ʻike a me ka hana hoʻokūkū.

Reference:

  • Giustarini D, Milzani A, Dalle-Donne I, Tsikas D, Rossi R. N-Acetylcysteine ​​ethyl ester (NACET): a novel lipophilic cell-permeable cysteine ​​derivative me kahi hiʻohiʻona maʻamau ʻo pharmacokinetic a me kekahi mea hiki mai antioxidant. Pāpaʻa Biochem. 2012 Dec 1; 84 (11): 1522-33. doi: 10.1016 / j.bcp.2012.09.010. Epub 2012 Sep 20. PMID: 23000913.
  • S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) a me nā lako N-acetyl-L-cysteine ​​etyl ester (NACET) -Ny moho hāmeʻa e pili ana i ka lāʻau lapaʻau me nā mea lapaʻau hoʻonaninani kūʻokoʻa no ka hoʻohana ʻana i ka waha ma mua he NO, H2S a me nā mea hāʻawi GSH e like me antioxidants: Nā hopena a me ka ʻike. 2018 Feb; 8 (1): 1-9. doi: 10.1016 / j.jpha.2017.12.003. Epub 2017 Dec 13. Review. PMID: 29568662
  • N-acetylcysteine ​​ethyl ester as GSH enhancer in human primothelial cell: He hui hoʻohālikelike me nā lāʻau ʻē aʻe. 2018 Oct; 126: 202-209. doi: 10.1016 / j.freeradbiomed.2018.08.013. Epub 2018 Aug 14. PMID: 30114478.
  • DimitriosTsikasa, Kathrin S.Schwedhelma, Andrzej Surdackib, Daniela Giustarinic, Ranieri Rossid, Lea Kukoc-Modune, George Kediaf, Stefan Ückertf. S-Nitroso-N-acetyl-L-cysteine ​​ethyl ester (SNACET) a me N-acetyl-L-cysteine ​​ethyl ester (NACET) –Ny moho hāmeʻa e pili ana i ka lāʻau lapaʻau ʻia me nā mea lapaʻau hoʻonaninani kūʻokoʻa no ka hoʻohana ʻana i ka waha ma mua he NO, H2S a me nā mea hoʻolako GSH e like me antioxidants: Nā hopena a me ka ʻike. Ka Nūpepa o ka ʻAkahi Huila. Volume 8, Lahui 1, Pepeluali 2018, ʻApana 1-9.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.