Nicotinamide riboside chloride (NR-CL) (23111-00-4) wikiō
ʻO Nicotinamide riboside chloride (NR-CL) (23111-00-4) Snāʻike
| Product Name | ʻO Nicotinamide riboside chloride (NR-CL) (23111-00-4) |
| Hawaiian Name | NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; ʻO Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL; |
| Kāleka CAS | 23111-00-4 |
| InChIKey | YABIFCKURFRPPO-IVOJBTPCSA-N |
| SMILE | C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-] |
| Ka Lā Molecular | C11H15ClN2O5 |
| Molecular Weight | 290.7002 |
| Monoisotopic Mass | 290.066949 g / mole |
| Point Hoʻolālā | N / A |
| kala like 'ole | keʻokeʻo |
| Shoʻoweliweli temp | -20 ° C Pākiho |
| noi | i nā meaʻaiʻaiʻaiʻai, nā lāʻau lapaʻau |
He aha ʻO Nicotinamide riboside chloride(NR-CL)?
ʻO Nicotinamide riboside (NR) kahi mea hou i ʻike ʻia ka nikotinamide adenine dinucleotide (NAD +) i ka vitamine. Kapa ʻia ka ʻano like me ka NR chloride i kapa ʻia ʻo NIAGEN, he ʻano synthetic o ka ribotide nikotinamide a he kumu kahi ia o ka nikotinamide ma ke ʻano o ka waikawa ʻo nikotinic ma ke bioavailable a ua manaʻo paʻa ia he palekana (GRAS). ʻO NR chloride ke kumuhana o nā meaʻaiʻai hou ʻelua no ka hoʻohana ʻana i nā mea kanu meaʻai.
ʻO Nicotinamide Riboside Chloride kahi mea kūlohelohe i loaʻa i ka waiū. Pili maoli ia i ka niacin a me nā ʻano o ka wikamina B3. Ua ʻike kekahi mau noiʻi ua loaʻa i nā Nicotinamide Riboside Chloride kekahi mau ʻano kūʻokoʻa i hiki ke hoʻonui i ka metabolism e kōkua ai i ka puhi ʻana i nā calori hou aku a pale i ka loaʻa ʻana o ke kaumaha. Ma waho aʻe o ka pohō kaumaha, kōkua pū ia i ka hoʻoikaika i ka hana i nā mākala, hoʻonui i nā lilo ikehu, a hoʻoliʻiliʻi i nā pilikia o ka maʻi kō.
Eia kekahi, he noiʻi i loko o nā kānaka i hōʻike ʻia e hoʻohaʻahaʻa ka Nikotinamide Riboside Chloride i nā pae NAD +, e kōkua ana i ka hoʻomaʻemaʻe i kekahi mau kūlana e pili ana i nā makahiki, ʻoiai ʻoi aku ka wikiwiki e ʻike akā pehea ia.
pomaikai o ʻO Nicotinamide riboside chloride(NR-CL)
ʻO Nicotinamide riboside chloride kahi ʻano synthetic o ribotide nikotinamide, like kona mau pono / hana me nicotinamide riboside. Ke komo nei i ka metabolism i ke kino, hiki ke hoʻohana ʻia e pale ai i ka pellagra a i ʻole nā maʻi defection niacin ʻē aʻe a e hoʻohaʻahaʻa i ka kolesterol a me nā triglycerides i loko o ke koko. Hoʻohana ʻia ia e hoʻohaʻahaʻa i ka makaʻu o ka puʻuwai puʻuwai i ka poʻe me ke kolesterol kiʻekiʻe i loaʻa i ka puʻuwai puʻuwai. Hoʻohana ʻia ia i kekahi manawa e mālama i ka maʻi o ke aʻa aʻa (atherosclerosis), pale i ka pale o ka lolo a me ke akepaʻa (ka lolo, ka maʻi kō, ka maʻi ʻo Alzheimer).
ʻO ka ʻokoʻa, ʻo Nicotinamide riboside chloride he pono ʻē aʻe i kekahi kanaka:
- ʻO ka hoʻowalewale kūpono a me ka hoʻopili ʻana o nā protein a me nā momona;
- Kōkua i ka hoʻololi ʻana i ka nui amino acid tryptophan i loko o ka niacin;
- Hoʻemi i ka luaʻi, a hōʻemi i nā hopena o ka lawe ʻana i nā antidepressants ma muli o ka malo maloʻo a paʻakikī hoʻi ka ʻūhū ʻana;
- Hoʻololi i ka syntatic acid synthesis a pale aku i ka wā kahiko o nā ʻiʻo a me nā ʻōpū, no laila e hoʻokō i ke kumu o ka lohi i ka wā kahiko;
- Ka hoʻolōʻihi i ka huelo nocturnal hoonui, spaly paralysis a me nā wāwae a me nā wāwae;
- Hoʻomaopopo i ka hypometabolism congenital a me ka hoʻonui ʻana o ka hana ʻaina;
- ʻO ka pale a me ka mālama ʻana i ka pauʻa o ka vitamin B6;
- Ka hopena o ka carpal tunnel syndrome;
- Kōkua ka hoʻolilo ʻana i ke kaumaha a hoʻoikaika i ka hana pono.
- Hoʻonui i ke kūpaʻa o ke kino i nā hunaola maʻi ʻaʻai
- Kāohi i ka nalo lohe
- He diuretic kūlohelohe.
- ʻO ka lawe ʻana i nā dosage nui e hiki ke hōʻoluʻolu i ka hoʻohui lāʻau a loaʻa iā ia kahi hopena detoxification maikaʻi.
- E hoʻomaikaʻi i ka hana o nā pūʻumi epidermal, a me nā hana o nā mea ʻē aʻe o ke ʻano kino o ke kanaka, e mālama i ka ʻālamalama o ka ʻili.
ʻO Nicotinamide riboside chloride(NR-CL) hoʻohana
Ma muli o ka Nicotinamide riboside chloride he waiwai pono lāʻau lapaʻau, hoʻohana pinepine ʻia ia i nā waihona meaʻai, ka lāʻau a me ka māla feedstuff.
Reference:
- Conze D, Brenner C, Kruger CL. ʻO ka palekana a me ka metabolism o ka hoʻokele wā lōʻihi o ka NIAGEN (Nicotinamide Riboside Chloride) i kahi Randomized, Double-Blind, Placebo-hoʻokolohua hoʻokolohua hoʻokolohua o nā pākaha momona. Sci Rep. 2019 Jul 5; 9 (1): 9772. doi: 10.1038 / s41598-019-46120-z. PMID: 31278280 PMCID: PMC6611812.
- ʻO Bogan, KL, Brenner, C. (2008). "ʻO ka Nicotinic acid, nikotinamide, a me ka ribotide nikotinamide: kahi loiloi molekole o ka NAD + precursor vitamins i ka meaʻai kanaka". Annu. Rev. Nutr. 28: 115-130. hana: 10.1146 / annurev.nutr.28.061807.155443. PMID 18429699.
- Chi Y, Sauve AA (Nowemapa 2013). "ʻO Nicotinamide riboside, kahi nutrient trace i nā meaʻai, kahi huaola B3 me nā hopena ma ka ikehu metabolism a me ka neuroprotection". Mālama Curr Opin Clin Nutr Metab Care. 16 (6): 657-61. hana: 10.1097 / MCO.0b013e32836510c0. PMID 24071780.
