J-147 pauka (1146963-51-0) wikiō
J-147 pauka (1146963-51-0) Nā kikoʻī
| Product Name | Ka pā'ālua J-147 |
| 'O Synonyms | J147; j 147; N-(2,4-Dimethylphenyl)-2,2,2-trifluoro-N'-[(E)-(3-methoxyphenyl)methylene]acetohydrazide |
| Kāleka CAS | 1146963-51-0 |
| Kōpana Drug | ʻAʻoheʻikepili i loaʻa |
| InChI Key | HYMZAYGFKNNHDN-SSDVNMTOSA-N |
| SMILE | CC1=CC(=C(C=C1)N(C(=O)C(F)(F)F)N=CC2=CC(=CC=C2)OC)C |
| Ka Lā Molecular | C18H17F3N2O2 |
| Molecular Weight | 350.341 g / mole |
| Monoisotopic Mass | 350.124 g / mole |
| Point Hoʻolālā | ʻAʻoheʻikepili i loaʻa |
| ʻO Boiling Point | ʻAʻoheʻikepili i loaʻa |
| Ehapalua ola | ʻAʻoheʻikepili i loaʻa |
| kala like 'ole | ʻO ka'ōmaʻomaʻo i ka paukūʻeleʻele |
| Palekana | DMSO (>30 mg/ml) a i ʻole EtOH (>30 mg/ml) |
| Shoʻoweliweli temp | hoʻopiha |
| noi | lāʻau hoʻokolohua me nā hopena i hōʻike ʻia e kūʻē i ka maʻi ʻelua o Alzheimer a me ka ʻelemakule ma nā ʻano ʻiole o ka ʻelemakule wikiwiki |
J-147 Nānā Hou
Ua hele mai ka pauka J-147 ma 2011 ma ka Cellular Neurobiology Laboratory o ka Salk Institute. Mai kona hoʻomaka ʻana, ua nui nā noiʻi i hōʻoia i kona pono i ka mālama ʻana i ka maʻi Alzheimer a me ka hoʻohuli ʻana i ke kaʻina hana ʻelemakule.
ʻO Kauka Dave Schubert me kona mau hoa ʻimi noiʻi ma ka Salk Institute i hana nui i ka hoʻopaʻa ʻana o J-147 curcumin. I ka 2018, wehe nā neurobiologists i ka hana J-147 o ka hana o ka nootropic a me kāna kuleana i ka mālama ʻana i nā maʻi neurodegenerative.
ʻO ke aʻo ʻana a me ka noiʻi ʻana o kēia lāʻau lapaʻau e pili ana i kona koʻikoʻi i ka mālama ʻana i ka maʻi o Alzheimer. Eia naʻe, ua hoihoi nā mea hoʻohana olakino i nā pōmaikaʻi J-147 e like me ka hoʻonui ʻana i ka hoʻomanaʻo, hoʻonui i ka hiki ke aʻo, a me ka rejuvenation o nā neurons.
I ka makahiki 2019, ua hoʻomaka nā kauka lāʻau e hoʻokolohua me ka lāʻau lapaʻau J-147 Alzheimer i ke kanaka.
He aha ka pauka Nootropic J-147?
ʻO ka pauka J-147 e loaʻa mai ka curcumin a me Cyclohexyl-Bisphenol A. ʻO ka lāʻau lapaʻau akamai he mau neuroprotective a me nā waiwai neurogenic. ʻAʻole like me ka hapa nui o nā nootropics, J-147 anti-aging supplement e hoʻonui i ka cognition me ka ʻole o ka hoʻopili ʻana i ka acetylcholine a i ʻole phosphodiesterase enzymes.
He kūleʻa ʻo Curcumin o turmeric a he mea maikaʻi ia i ka mālama ʻana i nā maʻi neurodegenerative. Eia nō naʻe, ʻaʻole hiki i kēia polyphenol keʻaʻa i ka pale o ka lolo-lolo me ka maikaʻi. A ʻo kahi hopena, ua lilo ʻo J-147 nootropic i poʻokela ʻoi loa ke keʻa i ka pale o ka lolo me ka maʻalahi.
Pehea e hana ai ʻo J-147?
A hiki i ka makahiki 2018, noho pohihihi ka hopena J-147 ma ke keena a hiki i ka wehe ʻana o ka Salk Institute Neurobiologists i ka nane. Hana ka lāʻau ma ke hoʻopaʻa ʻana iā ATP synthase. Hoʻololi kēia mitochondrial protein i ka hana o ka ikehu cellular, no laila, ka kaohi ʻana i ke kaʻina ʻelemakule.
Ke alo nei o ka J-147 kumukanawai i loko o ka ʻōnaehana o ke kanaka e pale aku ai i nā onaona pili i ka makahiki i hopena ʻia mai ka mitochondria me ka hana nui ʻole o ATP.
ʻO ka hana J-147 e hoʻonui i nā pae o nā neurotransmitters like ʻole me NGF a me BDNF. Ma waho aʻe, hana ia i nā pae beta-amyloid, i kiʻekiʻe mau i waena o nā maʻi me Alzheimer a me ka dementia.
ʻO nā hopena J-147 me ka hoʻolōʻihi i ka holomua o ka Alzheimer, ka pale ʻana i ka hemahema hoʻomanaʻo, a me ka hoʻonui ʻana i ka hana o nā neuronal cells.
Nā pono kūpono o J-147
Kuhi Hulu
Hoʻonui ka hoʻonui J-147 i ka hoʻomanaʻo spatial a me ka lōʻihi. Hoʻohuli ka lāʻau i nā kīnā ʻike i waena o nā ʻelemākule e hakakā nei me ka hōʻino o ka noʻonoʻo. Hāʻawi ʻia ʻo J-147 no ke kūʻai aku ma ke ʻano he mahele lāʻau over-the-counter a ke lawe nei ka hanauna ʻōpio e hoʻonui i ka hiki ke aʻo.
ʻO ka lawe ʻana i nā lāʻau anti-aging J-147 e hoʻonui i ka hoʻomanaʻo, ʻike, a me ka noʻonoʻo ʻana.
Ka mālama ʻana i ka maʻi Alzheimer
Hoʻomaikaʻi ʻo J-147 i nā mea maʻi me Alzheimer ma ka hoʻolōʻihi ʻana i ka holomua o ke ʻano. ʻO kahi laʻana, e lawe ana i ka waihona i nā pae o ka beta-amyloid soluble (Aβ), e alakaʻi ana i ka hana ʻole o ka naʻau. Ma waho aʻe, hoʻololi ʻo J-147 curcumin i ka neʻe ʻana o ka neurotrophin e hōʻoia i ke ola ʻana o ka neuronal, no laila, ka hoʻomanaʻo ʻana a me ka ʻike.
ʻO nā mea maʻi me AD ka mea i ʻoi aku ka liʻiliʻi o nā kumu neurotrophic. Eia nō naʻe, ke lawe nei i kā J-147 Alzheimer supplement e hoʻonui ai i ka NGF a me ka BDNF. Kōkua kēia mau neurotransmitters i ka hoʻokumu hoʻomanaʻo, ke aʻo ʻana, a me nā hana noʻonoʻo.
neuroprotection
ʻO ka J-147 nootropic e pale i ka make neuronal ma muli o ke koʻikoʻi oxidative.
Pākuʻi ʻia kēia kumukanawai i ka overactivation o NMDA (N-Methyl-D-aspartate) mau mea loaʻa, ke kuleana no ka neurodegeneration.
ʻO ka lawe ʻana i ka lāʻau J-147 e hoʻonui ai i nā kumu neurotrophic i loaʻa i ka lolo (BDNF) a me nā mea ulu o ke aʻalolo (NGF). Kipaku kēia mau neurotransmitters ʻelua i nā maʻi neurodegenerative e like me Alzheimer a me ka dementia. He aha hou aʻe, he mea nui ka BDNF i ka neurogenesis.
Hoʻomaikaʻi i ka hana Mitochondrial
ʻO ka lawe ʻana i ka lāʻau J-147 e hoʻomaikaʻi kūpono ʻole i nā pae ATP ma ka hoʻonui ʻana i nā hana mitochondrial.
ʻO ka ʻelemakule ke kuleana no ka emi ʻana o ka mitochondria ma muli o nā dysfunctionalities a me ka hoʻonui ʻana i nā ʻano oxygen reactive. Eia naʻe, hoʻopiʻi ʻo J-147 i kēia ʻano hana ma ke kāohi ʻana i ka synthase ATP5A. He nui nā haʻawina e pili ana i ka lāʻau no ka hoʻolōʻihi i ke ola o ke kanaka.
J-147 a me Anti-ʻelemakule
Wahi a Salk Researchers, ʻo J-147 anti-ʻelemakule kumukanawai i nā kūpuna kūpuna e hōʻike ʻōpio.
ʻO ka mitochondria paʻahana e hoʻonui i ka hana ʻelemakule. E hoʻemi ana ka homeostasis cellular, no laila, kahi hōʻemi o ka hana physiological. Ma waho aʻe o ka hopena o ka cell a me ka mitochondrial deterioration e pili ana ma muli o ka hana ʻana o ROS (oxygen species). Lawe i ka pauka J-147 e kūʻē i kēia hopena, no laila, e hoʻolohi ana i ka senescence.
Hoʻopili pū ʻia ka ʻelemakule me ka emi ʻana o ka cognitive a me nā maʻi neurodegenerative. Eia naʻe, ua hōʻoia kekahi mau ʻike J-147 i ka maikaʻi o ka lāʻau i ka hoʻohuli ʻana i ka nalowale o ka hoʻomanaʻo, hoʻomaikaʻi ʻana i nā mana cognitive, a me ka mālama ʻana i ka dementia, Alzheimer's, a me nā maʻi pili makahiki ʻē aʻe.
Hana Kūmole o J-147
(1) Ka mahele lāʻau maʻamau
Aia ka helu J-147 maʻamau i kēlā me kēia lā ma waena o 5mg a me 30mg. Hiki iā ʻoe ke hoʻokaʻawale i ka dosage J-147 i ʻelua. ʻOi aku ka maikaʻi, pono kāu maʻi ma ka pae haʻahaʻa a hoʻonui ʻia e pili ana i ka ʻae ʻana o kou kino.
Ke hana waha nei kēia mea hoʻohui. E hōʻole ʻoe i ka lawe ʻana ma hope i ke ahiahi a i ʻole i ka pō no ka mea ʻo kekahi mau loiloi J-147 e ʻōlelo nei e hōʻino paha i kāu ʻano hiamoe.
(2) Ka maʻi maʻi
Ua hoʻohana nā kānaka noiʻi i ka 10mg / kg o ka lāʻau J-147 e mālama ai i ka maʻi o Alzheimer i nā ʻano iole.
Eia nō naʻe, pili ka hopena ma kāu kūlana. Lawe, no ka laʻana, inā ʻoe ma hope o ka hoʻomaikaʻi ʻana i kou ʻike, pono ʻoe e hōʻoia e lawe i 5mg i 15mg. Kūlike ʻole, no ka pale neurological a me ka mālama ʻana i nā maʻi neurodegenerative, hiki iā ʻoe ke hoʻonui i ka lāʻau ma kahi o 20mg a me 30mg.
Ma nā ho'āʻo hoʻokolohua J-147, e lawe ka poʻe i ka maʻi ma hope koke o ka wikiwiki o 8 mau hola.
ʻO ka ʻokoʻa ma waena o J-147 a me T-006
ʻO T-006 kahi mea nui o J-147 nootropic. Ua hoʻolālā ʻia ka mea hoʻohui e ka hoʻololi ʻana i ka hui methoxyphenyl o ka pauka curcumin J-147 me ka tetramethylpyrazine.
ʻO ka hoʻohui ʻana me T-006 no kahi kokoke i ʻekolu mahina e hōʻemi i ka noe lolo a piʻi i ka ikehu holoʻokoʻa. ʻO ka mea ʻē aʻe, hoʻonui ka pauda i ka acuity waha a hoʻomaha ka mea hoʻohana. ʻO ka ʻokoʻa, loaʻa nā ʻike J-147 i hoʻomaikaʻi ʻia ka hoʻomanaʻo, ʻike, a me ka ʻala.
I loko nō o kēia mau mea ʻokoʻa ʻole, loaʻa nā hopena like i nā mea hoʻopili ʻelua.
Maluhia ʻo J-147 ke hoʻohana?
J-147 palekana ka lāʻau. Ua hala maikaʻi ʻia i ka hoʻāʻo ʻana i nā lāʻau i nā hoʻokolohua holoholona e like me ke koi a ka Food and Drug Administration (FDA). Eia kekahi, ua hoʻomaka ʻia nā hoʻokolohua hoʻokolohua J-147 no kekahi manawa.
ʻAʻohe moʻolelo o nā hopena ʻino J-147 ma nā hoʻokolohua preclinical a me nā kānaka.
ʻO J-147 hoʻokolohua hoʻokolohua
ʻO ka pae mua o ka hoʻokolohua hoʻokolohua J-147 i hoʻomaka i ka hoʻomaka mua o 2019 e like me ke kākoʻo ʻana o Abrexa Pharmaceuticals, Inc.
ʻO ke aʻo ʻana i ka maʻi lapaʻau me nā ʻōpio a me nā ʻelemākule. Ua hoʻonohonoho ʻia ka pūʻulu noiʻi, makapō makapō, a me kahi placebo-kāohi ʻia me nā ana piʻi hoʻokahi.
I ka pau ʻana o ka hoʻokolokolo kanaka, e hoʻokumu nā ʻepekema i ka hopena e pili ana i nā hopena ʻino, ka puʻuwai puʻuwai a me ke kani, nā loli kino, a me nā pono J-147 ma ka ʻōnaehana neurological.
ʻO ka loiloi hoʻohana / ʻike ma hope o ka hoʻohana ʻana iā J-147
Eia kekahi o nā loiloi J-147;
Wahi a ka Capybara;
“… Hiki i kekahi ke ʻano o ka ikaika loa i ka hoʻomaka. ʻAʻole kahi ʻano caffeine a i ʻole amphetamine o ka ikehu, akā ʻoi aku ka ikehu maoli. Ua hauʻoli wau i kēia pae mai ka hiki iaʻu ke noʻonoʻo e pili ana i ka hana ʻana i kekahi mea e like me ka holo kaʻa, a laila hana me ka hopohopo ʻole a i ʻole e hōʻoiaʻiʻo iaʻu e hoʻomaka. ʻO ka hoʻonāukiuki iaʻu iho he hana ʻole. Ua hoʻopau ʻia kēia ma hope o kekahi mau pule, a ʻoiai ua hauʻoli wau i kēia manaʻo, ʻaʻole paha nā mea ʻē aʻe, a no laila ke helu nei wau i kēia ma ke ʻano he hopena hopena. "
'Saysleloʻo F5fireworks;
"Me he mea lā he nootropic hoihoi a hoʻohiki hoʻi. Aia paha kahi noiʻi lapaʻau i ka US i ka makahiki i hala. "
Wahi a kekahi mea hoʻohana;
"ʻAe, ua loaʻa iaʻu i nehinei a ua lawe au i 10mg no 3 mau lā. Ua lawe au iā ia ma muli o ka hana a hemo maikaʻi loa ia. ʻAno maikaʻi ʻole. Hoʻomaka loa ka hopena koke iaʻu. ʻO kaʻu hihiʻo a me koʻu noʻonoʻo me he mea lā ua ʻoi aku ia, akā he placebo wale nō ia. Me he mea lā ʻaʻohe hopena maikaʻi ʻole, akā wikiwiki ia e haʻi ... ua maikaʻi wau i nā mea āpau a hoʻoikaika i ka lā holoʻokoʻa me 10 mg hou i ke kakahiaka ma kahi o 6 am. ”
'Leloʻo Fafner55;
"Ke hoʻomau nei wau i ka lawe ʻana iā J147 me ka loaʻa ʻole o ka pōmaikaʻi ʻē aʻe ma mua o ka hoʻemi ʻia ʻana o ka mumū a me ka pehu i hōʻike mua ʻia."
J-147 mea hana pauka - Ma hea mākou e kūʻai ai i ka pauka J-147?
ʻO ke kānāwai o kēia nootropic he iwi hakakā akā ʻaʻole ia e pale iā ʻoe mai ka loaʻa ʻana o nā huahana kūpono. Ma hope o nā mea a pau, ke hoʻomaka nei nā hoʻokolohua lapaʻau o J-147 Alzheimer. Hiki iā ʻoe ke kūʻai i ka pauka ma nā hale kūʻai pūnaewele ke loaʻa iā ʻoe ka kuleana e hoʻohālikelike i nā kumukūʻai J-147 ma waena o nā mea kūʻai aku. Eia nō naʻe, pono ʻoe e hōʻoia i ka kūʻai ʻana mai nā mea hoʻolako kūpono me ka hoʻāʻo ʻana i ke keʻena kūʻokoʻa.
Inā makemake ʻoe i kahi J-147 no ke kūʻai aku, e nānā pū me kā mākou hui. Hāʻawi mākou i nā nootropics he nui ma lalo o ka mana maikaʻi. Hiki iā ʻoe ke kūʻai i ka nui a i ʻole e kūʻai i hoʻokahi kūʻai ma muli o kāu pahuhopu psychonautic. E ʻoluʻolu e hoʻomanaʻo i ke kumu kūʻai J-147 wale nō ke kūʻai ʻoe ma ke kūʻai nui.
E hoʻomaopopo '
- Lapchak, AP, Bombien, R., a me Rajput, SP (2013). ʻO J-147 kahi Novel Hydrazide Lead Compound e mālama i ka Neurodegeneration: Ceetox TM Palekana a me Genotoxicity Analysis. Ka Nupepa o Neurology a me Neurophysiology.
- Ma mua, M., et al. (2013). ʻO ka Neurotrophic Compound J147 Huli i ka Hewa Cognitive i nā ʻiole maʻi ʻo Alzheimer ʻo Aged. ʻO Alzheimer Research & Therapy.
- Hoʻohuli ka lāʻau lāʻau a Alzheimer i ka uaki i ka Powerhouse of Cell. Ke Alanui Institute.Ianuali 8, 2018.
- Qi, Chen., Et al. (2011). Kahi lāʻau Neurotrophic Novel no ka hoʻonui ʻana i ka cognitive a me ka maʻi ʻo Alzheimer. Waihona Puke o ka ʻEpekema.
- ʻO Daugherty, DJ, et al. (2017). ʻO kahi Novel Curcumin Derivative no ka hoʻomaʻamaʻa ʻana i ka Diabetic Neuropathy.
- Lejing, Lian., et al. (2018). Nā hopena anti-depressant-like o kahi Novel Curcumin Derivative J147: Ke komo ʻana o 5-HT1A ʻO Neuropharmacology.
