ʻO ka quinone Pyrroloquinoline (PQQ) (72909-34-3)

March 11, 2019
SKU: 108-09-8
5.00 i waho o 5 ma muli o 1 Customer pane lākiō

ʻO ka pyrroloquinoline quinone (PQQ) i kapa ʻia ka methoxatin, he cofactor ulaula. Loaʻa ʻia i ka lepo a me nā meaʻai e like me ka kiwifruit, e like me …… ..


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

ʻO ka quinone Pyrroloquinoline (PQQ) (72909-34-3) wikiō

Pyrroloquinoline quinone (PQQ) (72909-34-3) Nā hiʻohiʻona

Product Name Quinone Pyrroloquinoline (PQQ)
Hawaiian Name Coenzyme PQQ; Methoxatine; Pyrrolo-quinoline quinone;

Pyrroloquinolinequinone,4,5-Dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, Methoxatin, PQQ;4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid

Kāleka CAS 72909-34-3
InChIKey MMXZSJMASHPLLR-UHFFFAOYSA-N
SMILE C1=C(C2=C(C(=O)C(=O)C3=C2NC(=C3)C(=O)O)N=C1C(=O)O)C(=O)O
Ka Lā Molecular C14H6N2O8
Molecular Weight 330.21
Monoisotopic Mass 330.012415 g / mole
Ke Kula ʻo Boliing 1018.6 ± 65.0 ° C (Manaʻo ʻia)
Ke Alaula 569.8 ° C (1,057.6 ° F; 842.9 K)
nuʻa 1.963 ± 0.06 g / cm3 (Puhi ʻia)
kala like 'ole ʻ -lelo Hoʻolaha-ʻulaʻulaʻula
Nā kikowaena temp 2-8 ° C
Palekana Hoʻoheheʻeʻia i ka wai
noi Ua hōʻike ʻia ka PQQ e hana i ka wai waikā wai / cofactor a me kahi mea antioxidant. Hoʻohana ʻia no ia no ka hoʻohana ʻana i nā meaʻai i nā meaʻaiʻai, e like me ka ikehu, ke kau ʻana i ka pāʻina, a me nā pā paʻa i laila.

He aha ʻO ka quinone Pyrroloquinoline(PQQ)?

ʻO ka pyrroloquinoline quinone (PQQ) i kapa ʻia ka methoxatin, he cofactor ulaula. Loaʻa ia ma ka lepo a me nā meaʻai e like me ke kiwifruit, me ka umauma o ke kanaka. ʻO ka quinone Pyrroloquinoline kahi pyrroloquinoline i loaʻa nā pūʻulu oxo i ka 4- a me 5-kūlana a me nā hui carboxy ma ka 2-, 7- a me 9-mau kūlana. He kuleana ia e like me ka wai kala-wai kala a me kahi cofactor. A, he hālima hōʻailona ia no nā protein kinases e pili ana i ka hoʻohālikelike ʻana o nā sela mammalian. ʻO ka hiki ke hoʻoneʻe hou ʻia ʻo PQQ ka mea nui e hāʻawi iā ia i kahi ʻoihana lapaʻau e pale ai i ka neurodegeneration a me ka maʻi kanesa. (Ma ka mea e lilo ai ka redox, ʻo Pyrroloquinoline quinone kahi paʻa loa a hiki ke komo i nā haneli hou aku ma mua o nā antioxidants e like, me ka ascorbic acid, quercetin, a me epicatechin.

ʻO ka quinone Pyrroloquinoline kahi biofactor moʻolelo, a ua ʻike ʻia ʻo ia he cofactor enzyme i nā bacteria. Hōʻike nā hōʻike noiʻi inā loaʻa paha ʻo Pyrroloquinoline quinone ma nā hanana koi mua a me ka ulu ʻana. A he mea ulu nui o nā mea kanu ulu, aia i ka ulu o nā holoholona a me nā kānaka. Hoʻomaopopo ʻia ka quinone Pyrroloquinoline e komo i ka hana o nā hana olaola me nā pono ola kūlohelohe (ʻoi aku ka maikaʻi o ka ulu ʻana a me ka hana hoʻoulu) i nā holoholona.

Eia kekahi, ʻo Pyrroloquinoline quinone me nā hana antioxidant a me B-vitamin-like, me ka nui o nā pono pono no ka lolo a me ke kino. Hoʻokumu ia i ke olakino cognitive a me ka hoʻomanaʻo e ka hakakā ʻana i ka mitochondrial dysfunction a me ka pale ʻana i nā neurons mai i ka pōʻino poʻa. Ua hōʻike ʻia nā haʻawina haukaʻi i nā kānaka o ka Pyrroloquinoline quinone e hoʻonui i ka hoʻomanaʻo pōkole a me ka nānā ʻana, hoʻomaikaʻi i ka hoʻōla ʻana o ka ikehu a me ka wā o ke olakino olakino, a hōʻemi i nā mea hōʻailona o ka maʻi, a me ka hoʻomaikaʻi ʻana i nā manaʻo maʻamau o ka maikaʻi.

Pehea ʻo Pyrroloquinoline quinone(PQQ) hana?

Hōʻike nā papa hana ʻohi i ka hana maikaʻi no ka quinone Pyrroloquinoline i ka hoʻouluʻana i ka biogenesis mitochondrial. ʻO ka hepatocytes ratus i hoʻoiho ʻia me PQQ ma 10-30 μM no 24-48 h hōʻike i ka "hoʻonui nui citrate synthase a me ka hana cytochrome c oxidase, ka waiwai ʻo Mitotracker, ka maʻi DNA mitochondrial, a me ka hanu o ka oxygen cellular. ʻO ka hoʻokomo ʻana o kēia kaʻina hana ma o ka hoʻōla ʻana o ka cAMP pane element-binding protein (CREB) a me ka porexinome proliferator-activated activit-γ coactivator-1α (PGC-1α), he ala i ʻike ʻia e hoʻoponopono i ka biogenesis mitochondrial. " I nā haʻawina vivo i nā kiʻī kekahi e hōʻike pū i nā hopena maikaʻi mai ka papaʻaʻai me ka PQQ (2mg PQQ / kg o ka meaʻai). Hoʻopili kēia o ka triglycerides plasma, hoʻonui i ka lilo o ka ikehu. Hōʻike nā hōʻike hoʻokolohua o nā hōʻeha o ka hōʻeha a me nā hoiwi o ka maka o Pyrroloquinoline quinone e pili ana i ka make selona selona, ​​ma kahi ma waena o Pyrroloquinoline quinone e pale ana i ka N-methyl-d-aspartic acid (NMDA). Hōʻike nā kiʻina o ka maʻi maʻi o ka maʻi Parkinson e hoʻomau ka hoʻōla o Pyrroloquinoline i ka hōʻemi o ka neuronal, hoʻonui i nā mea hou o ka oxygen scavenging kaha, a hāʻawineuroprotection ma o nā hana hoʻomehana.

Nā pōmaikaʻi o ʻO ka quinone Pyrroloquinoline(PQQ) pōmaikaʻi

I loko o ka noʻonoʻo a me ke kino, PQQ he nui wale nā ​​pōmaikaʻi.

- PKākoʻo QQ maikaʻi i ka hana mitochondrial

ʻO Mitochondria nā mea hana ikehu i loko o kā mākou mau cell a he kuleana nui lākou i kā mākou olakino holoʻokoʻa. ʻO ka PQQ ma ka pale ʻana i ka mitochondria i kēia manawa a hoʻolaha i ka hanauna mitochondrial, no laila e hana iā ATP (Energy). ʻO ka mitochondria kaʻoi aʻe o ka hana, ʻoi aku ka ikaika.

- Kā kākoʻo ʻo PQQ i nā mea ulu ulu

Hoʻopuka ka PQQ i ka hoʻokumu ʻana o ka Nerve Growth Factor (NGF.), Pale a mālama i nā ʻōpū o nā lolo a me nā nerve, no laila e pale aku i ka emi ʻana o ka cognitive (hoʻoluhi hoʻomanaʻo, hopohopo hoʻoweliweli, a pēlā aku) ma muli o ka makahiki, ke kiki a i ʻole ka neurodegenerative disorders. hana, a me ka pale mai ka hanana ischemic cardiac a me ka hanana.

- PQQ pale i ka paʻakai oxidative

Hāʻawi ka PQQ i ka pale antioxidant ikaika, pale i nā ʻōpū i loko o ke kino mai ka pōʻino o ka oxidative a me ka demage free radical. Kākoʻo ia i ka metabolism o ka ikehu a me ka olakino olakino, a ua noʻonoʻo ʻia i kahi cofactor hou me ka hana antioxidant a me ka hana B-like-vitamin.

Ma waho aʻe, hiki paha i ka PQQ ke pale aku i ka mālama ʻana i ka pōʻino a me ka hana anticancer ikaika.

Ke noi / hoʻohana 'ana o ʻO ka quinone Pyrroloquinoline(PQQ)

Ma kahi noiʻi 2009 i paʻi ʻia ma ka nūpepa olakino ʻo Food Style, ua hōʻike ʻia ʻo Pyrroloquinoline Quinone i ka hiki ke pale aku i ka pale. Hoʻohana ʻia e mālama i ka hoʻohaʻahaʻa cognitive (neʻe ʻana i ka hoʻomanaʻo, hoʻoweliweli aʻoi aku, etc.) ma muli o ka makahiki o ke kuhi, ka maʻi a me nā pilikia neurodegenerative, a me ka pale mai ka hanana ischemic cardiac a me ka neurological. Ua hōʻike ʻia nā hopena like i loko o kahi hoʻokele hoʻokele ma 2011 kahi i hāʻawi ʻia ai ʻo Pyrroloquinoline Quinone me he mea la no kaʻai ʻana i ka papaʻai, e like me nā mea hoʻohua ʻai i ka waiū.

Pehea e loaʻa ai ʻO ka quinone Pyrroloquinoline(PQQ)?

I ke ola, hiki iā ʻoe ke loaʻa kekahi PQQ mai kekahi mau meaʻai momona, kū kūlohelohe ʻo ia ma kahi ʻano o nā meaʻai a me nā mea inu, ʻo ia hoʻi ka pepa kīmaha, pāhala, ʻili a me nā kiwifruit etc. akā, inā e helu ʻoe i ka nui o ka meaʻai e ʻai ai kekahi kanaka i kēlā me kēia lā, ʻo ka hapa nui ʻaʻole hiki iā mākou ke loaʻa i ka PQQ nui mai kā mākouʻai i kēlā me kēia lā. No laila, inā makemake ʻoe i nā pono keu aku, nui paha ʻoe e loaʻa PQQ e kekahi mau ala ʻē aʻe, e like me ka PQQ dietary supplementation.

Reference:

  • Drain, Kelsey (12 Pepeluali 2017). "Hiki i nā Antioxidant maoli e pale i ka maʻi maʻi". msn.com. Ua loaʻa iā 14 Pepeluali 2017.
  • Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). "Quinone Pyrroloquinoline: ʻo ka hoʻopuka e ka methylotrophs a me ka hoʻoulu ʻana i ka ulu ʻana no nā microorganism". Kūpono ʻO BioFactors. 1 (1): 51–3. PMID 2855583.
  • Felton LM, Anthony C (2005). "Biochemistry: ka hana a PQQ e like me ka cofactor enzyme cipactor?". Kalua. 433 (7025): E10, kūkākūkā E11–2. doi: 10.1038 / nature03322. PMID 15689995.
  • Westerling J, Frank J, Duine JA (1979). "ʻO ka hui prosthetic o methanol dehydrogenase mai Hyphomicrobium X: electron spin resonance hōʻikeʻike no kahi quinone struktur". ʻO Biochem Biophys Res Komun. 87 (3): 719–24. doi: 10.1016 / 0006-291X (79) 92018-7. PMID 222269.
  • Matsutani M, Yakushi T. Pyrroloquinoline quinone-hilinaʻi i ka dehydrogenases o nā mea acetic acid bacteria.Appl Microbiol Biotechnol. 2018 Nov; 102 (22): 9531-9540. doi: 10.1007 / s00253-018-9360-3. Epub 2018 Sep 15. PMID: 30218379.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.