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ʻO ka pāpū Caffeic acid phenethyl ester ka pauka (104594-70-9)

ʻO kaʻaila Kaʻikapika phenethyl ester ka pauka ka phenethyl waiʻona ester o ka mea'alakalo a me kahi mea ola ... ..


Kūlana: I ka Production Production
Mokuna: 25kg / Drum
nona iho: 1180kg / ka mahina

Description

ʻO ka pākī Kaloʻo acid phenethyl ester (104594-70-9)

ʻO ka pāpū Caffeic acid phenethyl ester ka pauka (104594-70-9) Snāʻike

Product Name ʻO ka pāpū Caffeic acid phenethyl ester ka pauka
Hawaiian Name Ka mea'alaka Caffeic acid phenethyl ester ka pauka;

ʻO ka caffeate Phenylethyl; ʻO ka Pestetyl caffeate; Ka meaʻona Caffeic 2-phenylthyl ester; β-Phenylethyl caffeate;

2-Phenylethyl (2E) -3- (3,4-dihydroxyphenyl) acrylate

Brand Name ʻAʻoheʻikepili no ka loaʻa
Kōpana Drug ʻO Tyrosine Kinase Hoʻonāuki, Hoʻopilikia
Kāleka CAS 104594-70-9
InChIKey KANUWAWKZWEQQ-VQHVLOKHSA-N
hakakino F'Oula C17H16O4
hakakino Wʻewalu 284.311 g / mole
Monoisotopic Mass 284.31 g · mol-1
Hoʻolaha Pʻo kaʻaila 125-126ºC (dec.)
ʻO ka paila 498.6 ± 45.0 ° C ma 760 mmHg
ʻO ka Halifa-Ola ʻAʻoheʻikepili i loaʻa
kala like 'ole i keʻokeʻo
Solakino Hoʻopaʻaʻia ma ka ethyl acetate ma 50mg / ml. Hoʻopukaʻia ma DMSO a me ka ethanol.
Ska hoʻokele Tka mahana E kūʻai i 0 ° C
ʻO ka pāpū Caffeic acid phenethyl ester kalo Apaukū He mea hōʻailona Cytotoxic e pili ana i nā laina pūpū. ʻO ka mea nāna i hana i ka ornithine decarboxylase a me ka tyrosine kinase pūmua. Loaʻaʻiaʻo ia he mea hōʻailona o ka mea kākau hōʻano, NF-kB. Ua hōʻikeʻia hoʻi i ka nui o ka hoʻopiliʻana i ke ala lipoxygenase o ka waikapona acid metabolic i loko o ka lume.

ʻO ka pāpū Caffeic acid phenethyl ester ka pauka (104594-70-9) Hōʻike

ʻO kaʻaila Kaʻikapila ka phenethyl ester ka pauka a me ka ester alcohol alcoholic ester o ka mea'alakalo a me kahi mea olapaʻa o ka hive propolis, me ka hana'āpana hana, cytoprotective a me nā pono hana. Ma luna o ka hoʻolālāʻana, hikiʻole i ka caffeic acid phenethyl ester kaala (CAPE) ka mea hoʻonā i ka hoʻonāʻana i ka mea kākau NF-kappa B a hiki iā ia ke hoʻopau i nā alaʻokoʻa hōʻailona p70S6K. Hoʻohui pūʻia ka CAPE i ka hoʻonuiʻiaʻana o nā puʻupuʻu puʻupuʻu maʻemaʻe e ka PDGF ma o ka hoʻonāukiʻana i ka kinzy kinosia pūmua P38 (MAPK) a me ka helu hypoxia-hoʻokomoʻia (HIF) -1alpha a me ka hoʻokomoʻana o hehe oxygenase-1 (HO-1) .

Uaʻikeʻia ka loaʻaʻana o kaʻeke caffeic acid phenethyl ester i nā kinoinoino, anti-inflammatory, a me nā pono immunomodulatory. Hoʻopilikia ka CAPE iā HIV-1. Ua manaʻoʻia nāʻano anti-inflammatory ma muli o ka hoʻopauʻiaʻana o ke ala lipoxygenase o ke kahe o ka waikadonic acid i ka CAPE. Ua hōʻike pū aku kaʻikeʻana i ka CAPE he mea hōʻokoʻa pono a hoʻonāuki paha i ka hoʻonāʻana o ka mea kākau NF kappa B, kahi puʻupuʻu pūnaewele e mālama ana i ka transcription o DNA. ʻO ka Caffeic Acid Phenethylester he mea hana i ka'ODC a me Tyrosine Kinase

ʻO ka caffeic acid phenethyl ester ka pauka (104594-70-9) Mākaukau o ka Hana

ʻO ka caffeic acid phenethyl ester he mea ia o ka propolis o nā hives o ka honeybee,'āpīpō i ka hoʻouluʻana NF-κB i hoʻokomoʻia e ka phorbol ester, ceramide, okadaic acid, a me hydrogen peroxide ma ke kāohiʻana i ke kāpiliʻana o ka p65 subunit o NF-κB i ka pūpū. Ma keʻano o nā laina pūlū tumor,ʻo ka Caffeic acid phenethyl ester e hōʻike ana i ka hana hana antiproliferative me EC50 o 1.76, 3.16, 13.7, a me 44.0 μM e pili ana i ka column murine 26-L5, murine B16-BL6 melanoma, HT-1080 fibrosarcoma kanaka a me ka maʻi A549 kanaka. nā laina lola adenocarcinoma, ma kēlā me kēia. ʻO ka caffeic acid phenethyl ester, he manaolapila nui, ke hoʻohana nei i kona hopena anti-apoptotic ma nā pūnaewele granulela ma ka paleʻana i ka hana a ROS a me ka hoʻoneʻeʻana i ka hana puʻupuʻu. Eia kekahi,ʻo ka Caffeic acid phenethyl ester ka mea i hoʻokomo i ka phenotype pro-inflammatory o LPS-hoʻonāukiʻia i nā HSC, a me ka hoʻokomoʻana o LPS i nā HSC i nā cytokines fibrogenic ma ka hanaʻana i ka hōʻailona NF-κB.

In vivo, Caffeic acid phenethyl ester (10 mg / kg, ip) hiki i ka ulu a me ka angiogenesis o nā maʻi koko mua ma C57BL / 6 a me BALB / cʻiole i hoʻopiliʻia me Lewis pulic carcinoma, kapalina kala, a me nā pūpili melanoma. ʻO ka'āpana caffeic acid phenethyl ester (5, 10, 20 mg / kg) hōʻike pū i nā hopena immunomodulatory i loko o ka nohoʻana ma o ka emiʻana o ka momona a me ka launa o kou momona a me ka'ō.

Ke hoʻohanaʻiaʻana o kaʻepa Caffeic acid phenethyl ester kaala (104594-70-9)

▪ Hoʻomāhala

▪ Aantiinflammatory

▪ Iimmunomodulator

▪ NFkB pa'ū

pomaikai o ʻO ka caffeic acid phenethyl ester ka pauka (104594-70-9)

ʻO ka Pestetyl caffeate he mea i loaʻa ma propolis, kahi hui i hanaʻia e ka pi. Hiki i ka caffeic acid phenethyl ester (CAPE) ke hoʻohana pono i ka paleʻana a me ka mālamaʻana i nā maʻi inflammatory, e like me ka maʻi rumatika, lupus erythematosus a me psoriasis, nā maʻi pipili a me nā maʻi e pili ana i ka hanuʻana, ka hōʻailona, ​​a me nā maʻi'ē aʻe e hopena mai i ke kaumaha. Eia kekahi, hiki ke hoʻohanaʻia ka CAPE no ka mālamaʻana i kahi maʻi o ka maʻi HIV ma ka huiʻana i loko o kahi hana lāʻau lāʻau me kahi mea e pāpā ai i ka hoʻopiʻiʻana o ka maʻi. Hiki ke hoʻohanaʻia i ka anti-atherosclerotic, antioxidative, cardioprotective, anti-obesity and antimitogenic.

NA HALO A E HOOLAHA:

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