L - (+) - Ergothioneine (EGT) (497-30-3)

March 15, 2020
SKU: 1010396-29-8
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ʻO Ergothioneine kahi hana waikina amino e kū mai ana a he thiourea derivative o ka histidine, aia i ka pūpū lepo ma ka …… ..


Kūlana: I ka Production Production
Mokuna: 25kg / Drum

L - (+) - wikiō Ergothioneine (EGT) (497-30-3)


L - (+) - Ergothioneine (EGT) ka lehu Snāʻike

Product Name L - (+) - Ergothioneine (EGT)
Hawaiian Name ʻOKAHOLOAE;

L-Ergothioneine;

Hoʻolaha;

l ergothioneine

Brand Name N / A
Kōpana Drug N / A
Kāleka CAS 497-30-3
InChIKey SSISHJJTAXXQAX-ZETCQYMHSA-N
hakakino F'Oula C9H15N3O2S
hakakino Wʻewalu 229.3 g / mole
Monoisotopic Mass 229.088498 g / mole
ʻO ka paila N / A
Fkū hou Pʻo kaʻaila N / A
ʻO ka Halifa-Ola N / A
kala like 'ole Kūleʻele a iʻole keʻokeʻo
Solakino Hoʻopau i ka wai (a hiki i ka 10 mg / ml)
Ska hoʻokele Tka mahana -20 ° C
Apaukū Ua hoʻohana ʻo l ergothioneine pauku i ka hoʻohui kino

L - (+) - Ergothioneine (EGT) (497-30-3) Hōʻailona

ʻO Ergothioneine ka hana waikina amino e kū mai ana a he thiourea derivative o ka histidine, aia i loko o kāʻona pele i ka pā imidazole. Hana ʻia kēia ʻano pūʻai i nā mea liʻiliʻi liʻiliʻi, ʻo Actinobacteria, Cyanobacteria, a me kekahi mau fungi. Pono ʻo Ergothioneine i kahi mea lawe kūikawā, EGT, i ʻike ʻia ʻo OCTN1 (hōʻailona hōʻailona SLC22A4), e komo i nā pūlaka. Ua hōʻoiaʻiʻo ʻia ka hōʻike EGT i nā laina pānaʻi kanaka a me nā holoholona a me kona hiki ke hoʻokau i ka ergothioneine i hoʻopaʻa ʻia i vivo.

L-ergothioneine kahi hana i kūlohelohe amino a he thiol / thione derivative o ka histidine. Loaʻa ka L-ergothioneine i nā ʻike koikoi o ka nui o nā pakanā a me nā maʻi a me nā haʻahaʻa ma lalo o nā meaʻai ʻē aʻe e pili ana i ka kīʻaha aliʻi, ka pipi, ka puaʻa, ka hipa a me ka moa.

ʻOiai ka noho ʻana o L-ergothioneine i nā meaʻai a nā kānaka e ʻai ai, ua nānā wale ʻia kona biosynthesis i kekahi mau baki a me nā pua.

He aha L - (+) - Ergothioneine (EGT) ?

ʻO ka L-Ergothioneine ka waikawa amino i loaʻa i ka nui o nā ʻūhā, akā i ka ʻāʻī aliʻi, ka ʻiʻo i nā holoholona i loaʻa i ka mauʻu i loaʻa nā ergothioneine, a me nā mea ʻai ʻē aʻe. ʻO nā mole Amino nā mea kanu e hoʻohana ai nā poloka hale no nā protein. Hoʻohana ʻia ka Ergothioneine i lāʻau lapaʻau.

Lawe ka poʻe i ka ergothioneine no ka pōʻino o ka puʻuwai, cataract, maʻi o Alzheimer, maʻi maʻi, a me ka maʻi puʻuwai.

L - (+) - ʻO ERGOTHIO kahi ʻano chiral amino-acid antioxidant biosynthesized i kekahi mau bakela a me nā pua. He mea nui e hoʻohui i ka bioactive i hoʻohana ʻia a ʻo ia ka mea hōʻano scicalnger, kahi kānana hihi ultraviolet, kahi hoʻoponopono o nā hāmeʻe o nā hoʻoneʻe i ka hoʻoneʻe ʻana a me nā bioenergetics cellular, a he cytoprotector physiological, etc.

Hoʻopili pinepine ʻia ʻo L-Ergothioneine i ka ʻili i ka hōʻili i ka ʻūhā, hōʻemi i nā hōʻailona o ka ʻiliʻili o ka ʻili, a hoʻēmi i ka pōʻino o ka lā.

L - (+) - pono ʻo Ergothioneine (EGT)

He mea ʻokoʻa ka L-ergothioneine ma ka hiki ke hiki i ka palena nui o kekahi mau kelepona e like me ka erythrocytes, ʻaʻole like me nā antiioxidants maʻamau e like me nā huaora C a me ka mea maoli he loina i mea e lawe ai i ka protein kalaka, ae ʻae ʻia e lawe pololei ka puʻuwai o nā huaʻelima. Pēlā ʻo ia nō ka ikaika o antioxidant intracellular, e like me ka nui o L-glutathione. Eia kekahi, ua hōʻike pū ʻia he chelator ikaika, hiki iā ia ke nakinaki i nā metala momona hōʻona, ʻoiai pale ʻia nā pūnāwai koko mai nā ʻano āpau.

Paipai ʻia e kona mau waiwai antioxidant, ua noiʻi nā mea noiʻi i nā hopena anti-inflammatory, ʻoiai ke hana nei ka ergothioneine ma waena o nā mea ʻē aʻe, ka cytokine pro-inflammatory, interleukin. L - (+) - Ergothioneine (EGT) no laila he nui nā waiwai e hana ana i loko o ke kino kanaka:

  • neutralizing react oxygen molekue (free radical), ka mea ke pale aku i ke kaumaha oxidative a hoʻemi i ka hōʻino ʻana i ka DNA mitochondrial, ka hoʻōla o ka protein a me ka lipid peroxidation;
  • Kelima - a i ʻole pahele - i nā cali metallic maikaʻi;
  • Hiki i hiki ke hoʻōla i nā enzyme antioxidant e like me glutathione peroxidase a i SOD, ʻoiai ke keakea nei i nā huina e hoʻopuka ai i ka radica superoxide;
  • Hoʻemi i ka manawa o nā haemoproteins e like me ka hemoglobin a me myoglobin;
  • Mālama i ka mitochondria;
  • ʻO L-ergothioneinereduces ka hopena o nā hopena UV, e like me ka pale i pale no ka mālama ʻili.
  • Mālama a mālama i nā pae o nā antioxidants e like me nā huaora C a me E, glutathione a me SOD;
  • Mālama i ka lolo mai ka neurotoxins a laila hoʻokani i ka pale pale e kū i ka emi cognitive;
  • Paipai i ka hanu cellular a me nā lipolysis momona, no laila e hoʻonui ai i ka ikaika a me ka stamina no ka hoʻoikaika kino;
  • I ka manawa e hui pū me ka acid hyaluronic, glucosamine, collagen, hōʻike ʻia i ka nui o ka hōʻemi ʻana i ka ʻehaʻeha ʻana a hoʻonui i nā pihi hoʻohui, e pili pū ana me nā hana hana postural maikaʻi, ma hope o ka hana ʻeono mau pule.

L - (+) - Ergothioneine (EGT) maluhia

ʻOiai l-ergothioneine ke kaʻana a i ka inoa a hiki mai ka ergot fungus, ʻaʻole i nā mea ʻino loa i kekahi ala.

He ʻoi aku ka paʻakikī o ka European Union ma mua o ʻAmelika Hui Pū ʻIa a ua hoʻoholo ʻo ia ka palekana o ka lako l-ergothioneine a palekana ʻole ka hopena i nā pākeke a me nā keiki.

Aia ka Panel i nā huahana Dietetic no ka Hoʻomaopopo ʻO ka Papa Hoʻomaʻi Pākīpika e palekana i nā lā maʻamau i nā lā 2.82 mg / kg o ke kaumaha o ke kino no nā pēpē, 3.39 mg / kg no nā keiki liʻiliʻi, a me 1.31 mg / kg no nā pākeke, me nā wahine hāpai a me ka hānai.

L - (+) - ʻO Ergothioneine (EGT) peni hana a me ke noi

Hoʻopili kūpono a me / a i ʻole e hoʻomaikaʻi ʻia ke kīlea me ka hua o ka lōʻihi e like me ka L-ergothioneine supplementine e hōʻemi i ka nui o ka hopena o ka hopena o ka maʻi maʻi a me ka wā kahiko.

ʻO ka pauka L-ergothioneine kahi mea kūpono kūpono no ka pākeke olakino, ka paila wai i hāʻawi ʻia.

Ua hōʻike aku ka noiʻi ʻana i nā hana pono anti ExidT e like me ka anti-inflammatory e pale aku i nā cell i nā maʻi physiological a me neurodegenerative.

  1. li nui

Hōʻike nā noiʻi e like me ka antioxidant, pale ʻo EGT i ka pale ʻana.

ʻO ka pīhoihoi Rheumatoid kahi maʻi autoimmune i hōʻailonaʻia e ka huhū (a i ʻole pinepine ʻike).

Hiki paha iā ia ke hōʻemi i ka maʻi o ka EGT i nā maʻi me ka rheumatoid arthritis.

  1. Nā maʻi neurodegenerative

Me he cytoprotectant, ʻo EGT kahi mea punahele punahele ma waena o nā mea maʻi a Alzheimer a me Parkinson.

Kākoʻo ʻo EGT i kāu ʻōnaehana antioksidan kūloko o kou kino a pale aku i nā pūpū o ka lolo mai ka hōʻeha o ka oxidative a me ke kaumaha mai nā radical free.

I ka pale aku i nā pūlima o ka lolo, hiki i ka nui ke pale i ka make o ka lolo ma kahi mua a pale i nā maʻi neurodegenerative.

  1. Ka maʻi maʻi

Mahalo i kona mau cytoprotectant a me nā mea antioxidant, ʻo EGT kahi puna amino amino punahele i nā mea maʻi me ka maʻi o ka naʻau.

  1. Nā Analaha Anuanu

E ʻike pinepine ʻoe iā EGT i nā huahana skincare no ka mea he ona cytoprotectant a me nā mea antioxidant- e pale aku paha i nā selu o ka ʻili mai ka ʻeha kino.

ʻO nā hōʻeha radical a me ke kaumaha oxidative he mea nui nui i ka ulia mua, ka ʻū ʻana o ka ʻili, a me nā manamana.

  1. Nā maʻi ʻeha

Ua hāʻawi ka US Department of Defense i kahi ʻāpana kālā no $ 1.34 miliona i nā mea noiʻi ma ke Kulanui o Colorado e aʻo i ka hana antioxidant o EGT no ka hakakā ʻana i nā maʻi ʻōlohelohe i ka poʻe koa.

Reference:

  • Oumari M, et al. ʻO ka hoʻoponopono ʻana o ka ergothioneine ma hope o ka hopena me ka oxygen singlet. Hoʻolaha ka lāʻau Radic Biol Med. 2019 Apr; 134: 498-504.
  • Cheah, LK, Halliwell, B. Ergothioneine; antioxidant hiki, hana pilikino a me nā hana i ka maʻi, Biochim. Nā Biophys. Acta 2012; (5): 784-793.
  • Genghof, DS Biosynthesis o Ergothioneine a me Hercynine e. Kuku me nā Actinomycetales, J. Bacteriol., 1970; 103 (2): 475–478.
  • ʻO ka repine, JE, Elkins, ND Pahu o ka ergothioneine ma ka hōʻeha pūpū a me ka huhū ʻana ma nā kīpoki i hoʻonāukiuki ʻia ʻo cytokine, Prev. Med. 2012; (54): S79-S82.
  • EFSA Panel i nā huahana Dietetic, nā meaʻono a me nā maʻi (2017). "'Onlelo e pili ana i ka palekana o ka synt-l-ergothioneine ma ke ʻano he mea kīhāpai - nā mea e pono ai nā meaʻai a me nā loiloi palekana no nā pēpē a me nā keiki liʻiliʻi, nā wahine hāpai a me nā hānai wahine". Hōʻike Pūnaewele EFSA. 15 (11): 5060. doi: 10.2903 / j.efsa.2017.5060.

NA HALO A E HOOLAHA:

E kūʻai ʻia ana kēia ʻano mea no ka noiʻi noiʻi wale nō. Wahi a ke kūʻai aku. ʻAʻole no ka loiloi kanaka, ʻaʻole lāʻau lapaʻau, manu hoʻāno, a i ʻole e kōkua ʻia nā mea hale.