sperm

Spermine a me polyamines

No laila he aha nā polyamine? A no ke aha lākou i koʻikoʻi ai i ka hana o ka ʻelemakule? Aia nā polyamines ma nā wahi a pau i loko o nā pūnaewele ola a me nā ʻiʻo. Ua ʻike ʻia lākou he biogenic amines i hui pū ʻia me ʻelua mau pūʻulu amino. Hiki maoli ka polyamines i loko o ko mākou kino a me ka pōʻino, ke emi nei kēia mau pae.

He kuleana ko Polyamines i:

• Māhele pūnaewele a me ka ʻokoʻa
• ʻO ka hoʻonui ʻana o ke kelepona
• ʻO ka DNA a me ka protein synthesis
• Homeostasis (ka hiki i ke kino ke hoʻololi a mālama i kahi kūlana paʻa)
• A me ka hōʻike gene (ke code o kahi gene i hoʻohana ʻia e kuhikuhi i ka synthesis protein)

Ke nānā nei i nā hana a pau o nā polyamines, hiki iā mākou ke ʻike i ke kumu e hopohopo ai mākou inā ʻo ka ʻelemakule e hāʻule ai ko mākou pae. ʻO kēia mau pūhui koʻikoʻi e pili nui ana i nā kaʻina o ka ulu ʻana o ke kelepona a me ka mālama ʻana i ke kūpaʻa genetic. No laila, kōkua lākou i ka lohi i ke kaʻina o ka ulu ʻana a hoʻomaikaʻi i ko mākou ola a me ko mākou ola olakino (ko mākou maikaʻi o ke ola). ʻO ka hāʻule ʻana o kā mākou pae polyamines no laila ke hōʻole nei iā mākou i kekahi mau pono therapeutic waiwai.

ʻO nā polyamine nui i loaʻa i loko o nā pūnana mammalian a me nā mea kanu ʻo spermidine, spermine, a me putrescine. He nui nā mea like ʻole o ke kanaka a me nā mea kanu, ʻo kekahi o ia mau mea ʻo ia kā mākou hana ʻelua i nā mea a pau e hiki ai ke ola i ka lōʻihi o ka hiki. ʻO kekahi o nā ala e hiki ai iā mākou ke hoʻokō ma o ka lawe ʻana i nā polyamines a me ka polyamine synthesis. Hoʻoikaika kēia kaʻina hana i ka autophagy, ʻo ia ke kaʻina hana o ko mākou kino e hoʻololi i nā cell i hōʻino ʻia me nā pūnaewele hou a hou. E like me kāu e noʻonoʻo ai, hiki i kēia kaʻina hana ke kōkua iā mākou e ola lōʻihi, hauʻoli, ola olakino. ʻO Spermine kahi laʻana o ka polyamine hiki ke kōkua i ka hoʻolaha ʻana i ka autophagy.

He aha ka Spermine?

ʻO Spermine kahi polyamine kūlohelohe i loaʻa i nā eukaryotes a pau, akā kakaikahi i nā prokaryotes. He mea nui ia no ka ulu ʻana o nā cell i nā ʻiʻo maʻamau a me nā neoplastic. Hoʻokumu ʻia ka sperm ma o ka hoʻohui ʻana o kahi hui aminopropyl i spermidine e ka spermine synthase. He mea koʻikoʻi ka Spermine ma ke ʻano, a ma ka hoʻonā wai i ka pH physiological, e ʻike ʻia kāna mau pūʻulu amino āpau ma ke ʻano he polycation.

Hiki ke hoʻohana ʻia ʻo Spermine i nā ʻano noiʻi olaola like ʻole ma ke ʻano he mea hoʻohui a mea hoʻoponopono. Hoʻohana ʻia e like me ka co-matrix me DHB no MALDI-MS o nā glycans sialylated ma ke ʻano ion maikaʻi ʻole.

He aha ka spermine tetrahydrochloride pauka?

ʻO ka Spermine tetrahydrochloride he polyamine e hoʻopuka ana i nā hopena modulatory like ʻole ma ka NMDA receptor channel, e hana ana ma kahi kahua kikoʻī ma ka paʻakikī e hiki ke hoʻoulu i nā hopena agonist a me nā antagonist. ʻO ka pauka Spermine tetrahydrochloride ka ʻano tetrahydrochloride o Spermine. ʻO ka pauka Spermine tetrahydrochloride he ʻano pauka keʻokeʻo ʻoiai ʻo Spermine free base i loko o ke ʻano wai. Ua like nā pōmaikaʻi o ka pauka Spermine tetrahydrochloride me nā pono Spermine.

Spermine Mechanism o ka hana: Pehea e hana ai?

Loaʻa ka sperm mai ka spermidine e ka spermine synthase. ʻO ka Spermine he polyamine, he cation organic liʻiliʻi i koi nui ʻia no ka ulu ʻana o nā cell eukaryotic. ʻO Spermine, loaʻa maʻamau i ka millimolar concentrations i loko o ka nucleus. Hana pololei ʻo Spermine ma ke ʻano he scavenger radical manuahi, a hana i nā ʻano mea hoʻohui like ʻole e pale ai i ka pōʻino oxidative i ka DNA. ʻO ka pōʻino oxidative i ka DNA e nā ʻano oxygen reactive he pilikia mau ia e pono e kiaʻi ʻia nā cell e ola ai. No laila, ʻo ka spermine kahi pūhui intracellular kūlohelohe nui i hiki ke pale i ka DNA mai ka hoʻouka kaua radical manuahi. Hoʻopili pū ʻia ʻo Spermine i ka hoʻoponopono ʻana i ka hōʻike gene, ka hoʻopaʻa ʻana o ka chromatin, a me ka pale ʻana i ka endonuclease-mediated DNA fragmentation.

Nā pōmaikaʻi ʻo Spermine - He aha ka spermine i hoʻohana ʻia no?

ʻO Spermine kahi polyamine endogenous e lawe ana i nā pūʻulu amino he nui. Ua ʻike ʻia e pāʻani i nā kuleana koʻikoʻi i ka metabolism cellular i nā cell eukaryotic āpau. ʻO Spermine, kahi polyamine kūlohelohe, ua puka mai nei e hōʻike ana i nā waiwai anti-kahiko. ʻO nā mea hoʻopihapiha sperm i hana ʻia e Spermine tetrahydrochloride pauka e hoʻonui i ke ola a me ke kū'ē ʻana i ke kaumaha, a hoʻemi i ka hiki ʻana o ka maʻi maʻi pili makahiki a me ka nalowale o ka hiki o ka locomotor.

Hoʻonui ka Spermine i ka nalowale o ka hoʻomanaʻo.
Ma hope o ka mālama ʻana iā Spermine, ua hoʻomaikaʻi maikaʻi ʻia ka hiki o ka hoʻomanaʻo ʻana i nā ʻiole SAMP8. ʻO ka pauka Spermine tetrahydrochloride i hoʻomaikaʻi maikaʻi i ka lōʻihi o ka manawa e ʻimi ai i ka mea hou.

Hoʻopau ka Spermine i ke koʻikoʻi oxidative i ka lolo o nā ʻiole.
Ua loiloi mākou i ka hopena o ka polyamine a me ka rapamycin i ke kaumaha oxidative. Ua hoʻemi ʻo Spermine i nā pae o MDA ma ka lolo o nā ʻiole SAMP8. Ua hoʻonui nui ʻia ka hana o SOD i ka hui o ka spermine. Ua hōʻike kēia mau hopena i ka Spermine tetrahydrochloride pauka e hoʻomaikaʻi nui i ke koʻikoʻi oxidative ma SAMP8.

Hoʻonui ka sperm i ka synaptic plasticity a me nā mea neurotrophic
Ua ʻike ʻia ka ʻōlelo o nā mea neurotrophic a me nā protein synaptic i ka hui spermine. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), postsynaptic density and postsynaptic density ua maopopo i ka hoʻomaikaʻi ʻana i ka hui o spermine.

Hoʻoponopono ʻo Spermine i ka hana mitochondrial
E like me ka hopena i hōʻike ʻia, ua hoʻomaikaʻi maikaʻi ʻia ka ʻōlelo o nā protein e pili ana i ka mitochondrion i ka hui spermine. Hoʻokomo maopopo ʻia ka Spermine i ka phosphorylation o DRP 1. Ua haʻahaʻa ka neʻe ʻana o ka ATP i ka hui ʻiole SAMP8 ma mua o ka hui spermine.

Hoʻoulu ka sperm i ka autophagy
Ma hope o ka mālama ʻana i ka pauka Spermine tetrahydrochloride, ua hoʻokiʻekiʻe ʻia ke kiʻekiʻe o ka phosphorylation o AMPK. Ua hoʻonui nui ʻia ka pae o nā protein e pili ana i ka autophagy i ka hui spermine.

Hoʻonui ka sperm i ka apoptosis

Hoʻopau ka sperm i ka mumū
E like me ka hopena i hōʻike ʻia, Ma hope o ka mālama ʻana i ka spermine, ua hoʻemi nui ʻia ka hōʻike o nā protein inflammatory. ʻO nā mea hoʻohui spermine i hana ʻia e Spermine tetrahydrochloride pauka hiki ke hoʻohaʻahaʻa i ka mumū i ka lolo.

Spermine a me Spermidine

He kuleana koʻikoʻi ka ʻike o ka spermidine a me ka spermine i loko o ka protein a me ka nucleic acid synthesis a me ke kūkulu ʻana, ka pale ʻana mai ka pōʻino oxidative, ka hana o nā kaila ion, ka hoʻonui ʻana o ka cell, ka ʻokoʻa, a me ka apoptosis.

ʻO Spermine kekahi ʻano polyamine. Pili nā pūhui ʻelua i kekahi i kekahi. Loaʻa ka Spermine mai Spermidine a he mea koʻikoʻi ia no ka metabolism cell i loko o ke kanaka a me nā mea kanu. ʻO ka lawe ʻana i nā mea hoʻohui spermidine e hōʻoiaʻiʻo e loaʻa iā ʻoe nā pono spermine pū kekahi.

Ka hoʻohana ʻana i ka pauka Spermine tetrahydrochloride

Ua hoʻohana ʻia ka pauka Spermine tetrahydrochloride e precipitate DNA no ka hoʻoheheʻe ʻana o ka cytometric mai ka ʻiʻo maʻi maʻi umauma maloʻo hou, ka waihona waihona o ka salivary gland, renal a me thyroid tumors2 a me nā keʻena koko ʻulaʻula o ka moa. I kēia manawa ua hoʻohana ʻia ka pauka Spermine tetrahydrochloride i nā mea hoʻohui anti-aging. E kūʻai aku i ka pauka Spermine tetrahydrochloride ma ka pūnaewele.

Ma hea e kūʻai ai i ka nui o Spermine?

I ka honua hou, hiki iā ʻoe ke kūʻai i nā mea hoʻohui Spermine i hana ʻia e Spermine tetrahydrochloride pauka ma ka ʻoluʻolu o kou home ma ka pūnaewele. Eia nō naʻe, pono ʻoe e nānā ākea no nā mea hoʻolako pauka Spermine tetrahydrochloride kiʻekiʻe. ʻO nā loiloi o nā mea kūʻai aku kahi ala e hōʻoiaʻiʻo ai i ka pono o ka pauka Spermine tetrahydrochloride a hōʻiliʻili pū i ka ʻike e pili ana i nā hopena ʻaoʻao spermine.

Nui nā spermine tetrahydrochloride pauka no ke kūʻai aku ma ka mākeke. ʻO Phcoker ma ke ʻano he hale hana hana e hāʻawi i ka nui o ka spermine tetrahydrochloride pauka. ʻO ka pauka spermine supplement maikaʻi loa me ka maʻemaʻe kiʻekiʻe a me ka bioavailability. E loaʻa i ke kumu kūʻai maikaʻi ka Spermine tetrahydrochloride pauka kūʻai kūʻai.

NPP

ʻO Spermine Anti aging?
ʻO kahi pepa i paʻi ʻia i ka makahiki 1992 i manaʻo ʻia e pale ka spermine a me ka spermidine i ka DNA mai ka hōʻino oxidative free-radical. Ke hāʻule nei kā mākou mau Spermine i ko mākou mau makahiki, ʻaʻole ia he nūhou maikaʻi iā mākou no ka mea e nalowale ana mākou i kēlā mau pono anti-kahiko a me ke olakino. Ma hoʻokahi hoʻokolohua, lilo nā ʻiole transgenic i hiki ʻole ke hana i ka spermine a me ka spermidine i ko lākou lauoho, loaʻa ka ʻili wrinkly, a make ʻōpio ma mua o nā ʻiole maʻamau, akā ʻaʻohe mea i ʻike ʻia i loko o kekahi o nā kino.

He antioxidant ka spermine?
Wahi a kekahi mau noiʻi, hiki i ka hoʻokele spermine ke hoʻonui i ka mana antioxidant i loko o ke ake a me ka spleen a hiki ke hoʻonui i ke kūlana antioxidant i ka spleen a me ka ate ma lalo o ke kaumaha oxidative. Ua ʻike ʻia ʻo Spermine ma ke ʻano he antioxidant potent a he anti-inflammatory agent. Aia ka pūhui i loko o nā mea ola a me nā ʻāpana āpau.

He aha ka hana o ka sperm i loko o ka sperm?
No ka mea he mea koʻikoʻi ka manawa kūpono o ka capacitation a me ka hopena acrosome no ka hoʻohua maikaʻi ʻana, ua manaʻo ʻia ʻo ke kuleana o ka spermine seminal ka pale ʻana i ka capacitation premature a me ka hopena acrosome.

Aia i hea ka spermine?
ʻO ka Spermine he polyamine, he cation organic liʻiliʻi i koi nui ʻia no ka ulu ʻana o nā cell eukaryotic. ʻO Spermine, loaʻa maʻamau i ka millimolar concentrations i loko o ka nucleus. Hana pololei ʻo Spermine ma ke ʻano he scavenger radical manuahi, a hana i nā ʻano mea hoʻohui like ʻole e pale ai i ka pōʻino oxidative i ka DNA.

He protein anei ka spermine?
ʻOiai he kuleana koʻikoʻi a kū hoʻokahi ka spermidine ma ke ʻano he precursor o hypusine kahi hoʻololi post-translational o ka elongation factor eIF5A, kahi mea e pono ai kēia protein e hana i ka synthesis protein, ʻaʻohe kuleana kūʻokoʻa no ka spermine i ʻike maopopo ʻia.

Pehea ʻoe e mālama ai i ka hopena spermine?
E mālama i ka 2-8 °C. Hoʻopili koke ʻia nā hopena o ka base free spermine. ʻOi aku ka paʻa o nā haʻina inā hoʻomākaukau ʻia i loko o ka wai degassed a mālama ʻia i loko o nā aliquots hau, ma lalo o ka argon a i ʻole ke kinoea nitrogen. ʻO ka pauka spermine tetrahydrochloride ka ʻano paʻa o ka waihona manuahi spermine.

No hea mai ka spermine?
Aia ka Spermine i loko o nā mea ola he nui e like me nā holoholona, ​​​​nā mea kanu, nā haʻani, kekahi archaea, a me kekahi mau bacteria. Hoʻopili ʻia ia e ka spermine synthase, kahi aminopropyltransferase kikoʻī. Loaʻa ka sperm mai ka spermidine e ka spermine synthase.

He aha ka pH o ka spermine?
No ka hōʻoia ʻana i ka hana biologically spermine ma ka pH 7.4 ua hoʻāʻo mākou i kona hopena ma nā mea hoʻokipa glutamate heterologously i hōʻike ʻia (GluR3)

He maikaʻi ka sperm no ka ʻili?
ʻO ka ʻoiaʻiʻo, ʻaʻohe hōʻike ʻepekema e kākoʻo i ka manaʻo o ka hoʻokomo ʻana i ka pua ma kou ʻili. Ma waho aʻe o ka hana liʻiliʻi e kōkua ai i kou ʻili, hiki ke hopena i nā hopena maʻi a me nā maʻi i lawe ʻia e ke kāne (STI).

1. ʻO kekahi o nā koi o ka pono o ka sperm no ka ʻili maka ʻo ia ka mālama ʻana i ka ʻekene. ʻO nā pōmaikaʻi o ka sperm no ka nani i manaʻo ʻia mai ka mea spermine. ʻO ka Spermine ka mea i loaʻa i ka waiwai spermidine i loko o ka semen kāne, i manaʻo ʻia he hana antioxidant a me ka anti-inflammatory agent. Ma waho aʻe o ka sperm kāne, hiki ke loaʻa ka spermine i loko o nā pūnaewele o ke kino kanaka. Manaʻo ʻia ʻo Spermine e mālama i ka ʻeʻe a me ka hakakā ʻana i nā ʻeleʻele.

ʻO ka mea pōʻino, ʻaʻohe hopena noiʻi ʻepekema e hiki ke hōʻoia i ka pono o ka sperm no ka ʻili ʻeleʻele.

2. Claims ʻO nā pōmaikaʻi o ka sperm no ka nani, ʻo ia ka pale ʻana i nā hōʻailona o ka wā ʻelemakule, e like me nā wrinkles a i ʻole nā ​​laina laina. Manaʻo ʻia ʻo Spermine he antioxidant hiki ke hoʻokaʻawale i nā hōʻailona o ka ʻelemakule, e like me nā wrinkles a me nā laina maikaʻi, e ʻoi aku ka ʻōpio. ʻO kahi haʻawina i paʻi ʻia ma ka puke pai Nature Cell Biology e ʻōlelo ana e hiki i ka spermine ke hoʻolohi i ke kaʻina hana ʻelemakule ke hoʻohana ʻia ma ka hoʻokomo pololei ʻana i loko o nā ʻili o ke kanaka.

Eia nō naʻe, ʻaʻole i hōʻoia ʻia nā pono o ka sperm no ka maka, i hoʻohana ʻia ma ka hoʻopili pololei ʻana i ka ʻili. ʻO ia hoʻi, ʻo nā pōmaikaʻi o ka sperm no ka maka o nā wahine i ka pale ʻana i ka wā ʻelemakule he moʻolelo wale nō.

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