α-ketoglutaric

ʻO wai nā inoa ʻē aʻe i ʻike ʻia e ka Alpha-ketgoglutaric acide?

A-cétoglutarate, A-Ketoglutaric Acid, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate dʻArginine, Alpha-Cétoglutarate de Calciine , ʻO Alpha-Cétoglutarate de Glutamine, ʻo Alpha-Cétoglutarate de L-Arginine, ʻo Alpha-Cétoglutarate de L-Leucine, ʻo Alpha-Cétoglutarate de Taurine, ʻo Alpha Keto Glutaric Acid, ʻo Alpha Ketoglutarate, ʻo Alpha Ketoglutaric Acid, Alpha KG, AAKG, AKG, Arginine Alpha -Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate, 2-Oxoglutaric Acid, 2-Oxopentan ʻĀkika.

He aha ka acid acid Alpha-Ketoglutaric?

ʻO ka Alpha-ketoglutaric (AKG) kahi waikawa olaola i mea nui no ka metabolism kūpono o nā amino acid pono āpau a me ka hoʻololi ʻana o ka ikehu cellular i ka pōʻaiapuni citric acid. He mea mua ia i ka glutamic acid, ka amino acid pono ʻole e pili ana i ka synthes synthes a me ke kaohi o nā pae glucose glucose. I ka hui pū ʻana me L-glutamate, hiki i ka AKG ke hoʻēmi i nā pae o ka amonia i hana ʻia i ka lolo, nā mākala a me nā puʻupaʻa, a kōkua pū me ke kaulike ʻana i ke kemika nitrogen o ke kino a pale i ka nui o ka nitrogen i loko o nā kino a me nā wai. ʻO nā kānaka me ka loaʻa ʻana o ka protein kiʻekiʻe, nā maʻi koʻohune, a i ʻole ka gastricestinal dysbiosis e pōmaikaʻi ʻia mai ka AKG kōkua e kōkua i ke kaulike i nā pae amonia a pale i nā aʻa.

Lawe kekahi poʻe i ka alpha-ketoglutarate e hoʻomaikaʻi i ka hana pāʻani kiʻekiʻe. Hāʻawi nā mea hoʻolako i nā mea hoʻowaiwai pāʻani ʻālapa he mea nui paha ka alpha-ketoglutaric acid i ka papaʻai kūpono a me ka hoʻomaʻamaʻa ʻana no ka mea ʻaʻa e makemake i ka hana kiʻekiʻe. Hoʻokumu lākou i kēia koi ma nā noiʻi e hōʻike ana i kahi amonia keu i loko o ke kino hiki ke hui pū me ka alpha-ketoglutarate e hōʻemi i nā pilikia e pili ana i ka nui o ka amonia (ʻona amonia). Akā, i kēia manawa, ʻo nā noiʻi wale nō e hōʻike ana i ka alpha-ketoglutarate hiki ke hōʻemi i ka lāʻau ʻona amonia i hana ʻia i nā maʻi hemodialysis.

Hāʻawi nā mea lawelawe olakino i kekahi manawa i ka alpha-ketoglutarate intravenously (e IV) no ka pale ʻana i ka ʻeha i ka puʻuwai i hoʻokumu ʻia e nā pilikia kahe o ke koko i ka wā o ka puʻuwai puʻuwai a no ka pale ʻana i ka haʻihaʻi o nā mākala ma hope o ke ʻoki a trauma paha.

Nā Hana o ka hana o Alpha-Ketoglutaric acid

ʻO nā ʻano hana o ka hana no ka α-Ketoglutarate ʻaʻole i wehewehe ʻia. ʻO kekahi o nā hana a α-Ketoglutarate e pili ana i ka hana ʻana i ka pōʻai Krebs ma ke ʻano he waena, nā hopena transamination i ka wā o ka metabolism o nā amino acid, e hana ana i ka waikawa glutamic ma o ka hui pū ʻana me ka amonia, a me ka hoʻēmi ʻana i ka nitrogen e ka hui pū ʻana pū me ia. No nā hana a α-Ketoglutarate me ka amonia, noi ʻia e hiki i ka α-Ketoglutarate ke kōkua i nā mea maʻi me ka propionic academia i loaʻa nā pae kiʻekiʻe o ka amonia a me nā pae haʻahaʻa o glutamine / glutamate i loko o kā lākou koko. Ma muli o ka hopena o ka glutamate / glutamine i hana ʻia mai α-Ketoglutarate, ua hoʻopōʻino nā mea maʻi propionic acidemia i ka hana ʻana o α-Ketoglutarate a me ka supplementation o α-Ketoglutarate e hoʻomaikaʻi ai i ke kūlana o kēia mau maʻi. Ua hōʻike pū kekahi mau noiʻi hoʻokolohua ʻē aʻe i ka lawelawe ʻana o α-Ketoglutarate i ka meaʻai makua i hāʻawi ʻia i nā mea maʻi ma hope o ka hana i kōkua i ka hoʻoliʻiliʻi o ka synthes muscle o ka protein muscle i ʻike pinepine ʻia ma hope o kahi ʻoki. Kuhi ʻia kēia hoʻoliʻiliʻi hoʻoliʻiliʻi musse ma muli o nā pae α-Ketoglutarate haʻahaʻa loa.

Kākoʻo ʻo Alpha ketoglutaric acid (AKG) - He aha nā pono o ka Alpha ketoglutaric acid?

ʻO Alpha-Ketoglutarate (AKG) ma ke ʻano he hoʻokō hoʻokō Athletic

ʻO ka Alpha ketoglutaric acid, a ʻo Alpha-ketoglutarate kahi huahana o ka mitochondria a he mea nui i ka hoʻololi ʻana i ka meaʻai i ka ikehu. He kumu ia no ka glutamine a me ka glutamate. I nā mākala, pale ka glutamine a me ka glutamate i ka haʻihaʻi o ka protein a hoʻonui i ka synthes protein.

Hoʻonui ka Alpha-ketoglutarate i ka hoʻokumu iwi. Hoʻoponopono ia i ka synthes o collagen ma o ka hoʻonui ʻana i ka nui o nā mole i loaʻa no ka synthes. ʻO Collagen kahi mea nui o ka iwi iwi.

Hoʻoulu ka Alpha-ketoglutarate i ka hana ʻana o ka insulin-like me ka mea ulu-1 a me ka ulu ulu. ʻO kēia nā hormones ʻelua e hoʻoponopono i ka hana hou ʻana o ka iwi a me ka hoʻokumu ʻana i nāʻiʻo iwi hou.

Pōmaikaʻi ka alpha ketoglutaric acid i ka ʻelemakule

Ua hōʻike ʻia nā noiʻi e hiki i ka AKG ke mālama i nā kūlana he nui ke lawe ʻia e like me ke kuhikuhi.

Eia nō naʻe, aia kekahi mau hōʻailona ʻē aʻe e hiki paha i ka Alpha-Ketoglutarate (AKG) ke kōkua me nā waiwai anti-kūnewa.

Hoʻokahi aʻo nui i mālama ʻia ma ka Buck Institute no Research on Aging me Ponce de Leon Health i loaʻa kahi hoʻomaikaʻi olakino e like me 60% i kā lākou mammalian hoʻopaʻa haʻawina.

Hoʻonui aku ʻo AKG i ke ola o nā mākua o C. elegans. (A) hoʻolōʻihi ʻo AKG i ke ola o nā ʻenuhe makua. (B) Piko-pane pālākiō o ka hopena AKG i ke ola lōʻihi.

Hoʻohui ʻia, ua hoʻokuʻu ʻo Ponce De Lon Health (PDL) i kahi hōʻike hoʻokolohua, ka hōʻike e hōʻike ana ma hope o ka hapalua makahiki, ua emi ka makahiki physiological o nā kumuhana ma ka awelika 8.5 mau makahiki ma hope o ka lawe ʻana i ka alpha-ketoglutarate (AKG) i loko o ka ʻoihana.

ʻO nā mea hoʻohui ʻē aʻe, e like me ka lāʻau antiamy rapamycin a me ka mālama ʻana i ka maʻi diabetes i hōʻike ʻia, ua hōʻike ʻia nā hopena like i nā hoʻokolohua iole. Akā AKG hana maoli ʻia e nāʻiole a me ko mākou mau kino ponoʻī, a ua manaʻo ʻia he palekana ia e ʻai ʻia e nā mea hoʻokele.

ʻO nā mea a mākou e pono ai e hoʻolohe aku, ʻo ia ka alpha ketoglutaric acid maʻakika loa a ʻaʻole maʻalahi e ʻai. Hoʻohui ʻia nā mea hoʻopiha hoʻoikaika kino ma ka mākeke me ka arginine-α-ketoglutarate (AAKG), ka mea nui o ia mau mea he arginine, ʻoiai ka mea i hoʻohana ʻia e Ponce De Lon Health he α-ketoglutarate calcium.

Loaʻa i ka Alpha-ketoglutarate kekahi mau pono pale-pale

Kāhea ʻia ʻo AKG ka meaola nutrient pale a he mea nui ia i ka metabolism immune āpau. Ua ʻike ʻia ʻo AKG kahi kumu nui o ka glutamine a me ka glutamate, ua wehewehe ʻia e like me ka homologue glutamine a me nā mea loaʻa. I ke kino, hoʻololi ʻia i glutamine. Hiki i ka glutamine ke hoʻonui i nā pae o nā hunaola keokeo (macrophages a me neutrophil) .AKG me ka homologue glutamine he waiwai immuno-hoʻonui, hiki ke mālama i kahi pale o ka ʻōpū, hoʻonui i nā hunaola a me nā hana o neutrophil a me phagositosis, hoʻoliʻiliʻi i ka hoʻoliʻiliʻi o ka maʻi i loko o vivo.

Reference:

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4. Mālama ʻo Hammarqvist F, Wernerman J, von der Decken A, ʻo Vinnars E. Alpha-ketoglutarate i ka synthes protein a me ka glutamine manuahi i nā mākala iwi ma hope o ke kahakaha ʻana. ʻOki kino1991; 109: 28-36.
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