ʻO Nicotinamide riboside (NR) a me ka nikotinamide riboside (Chloride)

ʻO Nicotinamide riboside (NR) chloride kahi ʻano chlorinated o ka nicotinamide riboside (NR).

1.He aha ka Nicotinamide Riboside (NR)?

ʻO NR kahi ʻano o ka huaʻai B3 a i ʻole niacin. Ua ʻike ʻia ka hui ʻana i nā makahiki 1940 ma ke ʻano he ulu ulu no H. influenza. I ka hoʻomaka o ka 21st kenekulia, nā helu o nā noiʻi e hōʻoia i ka NR i mua o NAD +. I ke kino o ke kanaka, hoʻohaʻahaʻa kēia nutrient i nā pae kolesterol, hoʻomāmā i ka makaʻi o nā maʻi maʻi maʻi, hoʻonui i nā hana o ka lolo, a hoʻoliʻiliʻi i ka maʻi kō.

ʻO Nicotinamide riboside (NR) kahi pyridine-nucleoside, e lawelawe ana ma ke ʻano mua i NAD + (Nicotinamide adenine dinucleotide). Hoʻohana ka NAD + i nā hanaolaola e like me ka hoʻoponopono ʻana o DNA, ka hanauna o ka ikehu paʻa, hoʻonohonoho ʻana i ka mana o ka kino o ke kino, a me nā mea hou aʻe. Minamina, hāʻule kūlohelohe kēia mau moleola me ka senescence.

2.He aha ka Nicotinamide Riboside (NR) Chloride?

ʻO Nicotinamide Riboside (NR) chloride (NIAGEN) kahi mea loaʻa o NR a me ka māʻalani. Hoʻonui ka hui i nā pae o NAD + a hoʻoulu iā SIRT1 a me SIRT3. Hoʻohuli ia i ka ʻelemakule e ka hoʻonui ʻana i ka metabolism oxidative a me ka pale ʻana i nā comorbidities metabolic pili i ka papaʻai.

I ka US nikotinamide riboside koloride ʻike ʻia he palekana. No laila, he mea hoʻohui papaʻai i ʻae ʻia no ka hoʻohana ʻana i nā lulu protein, nā wai huaora, nā gum, a me nā mea e pili ana kumukanawai a.

3.Panina

Ke pale nei ke kanaka i ka ʻelemakule e ka ʻimi ʻana i ka ʻili. I hoʻokahi manawa, ua ʻike paha ʻoe i kekahi Anati-oo hoi nā kalima no ka hoʻomaʻemaʻe ʻana i nā wrinkle hohonu o ka maka, ka pale ʻana o ka ʻili, a me ka blotchiness. Eia nō naʻe, kuhi hewa kēia mau mālama ʻana a me kahi wā pōkole. ʻO ke ala i hoʻohiki ʻia o ka ʻelemakule lokomaikaʻi ʻana ma o ka hoʻokumu ʻana i nā loli olakino ma hope o ka senescence a me ka hana ʻana me ke kumu kumu.

Ua hoʻokumu nā kānaka noiʻi mai ka pilina ma waena o nā pae NAD + haʻahaʻa a me nā maʻi e pili ana i ka makahiki. ʻO kēia ʻike radical ka icing o ka keke i ka laulā olakino e ka hoʻonui ʻana i ka likelika o ka hoʻohuli i ke kaʻina ʻelemakule. No kēia kumu, nicotinamide riboside chloride pauka ua hele pinepine i nā alaloa o nā keʻena hoʻokolohua hoʻokolohua hoʻokolohua ma muli o kona hopena i ka hoʻokahuli ʻana i ka uaki olaola.

ʻO ka wehewehe kemikala o ka Nicotinamide Riboside (Chloride) Powder

Product Name ʻO Nicotinamide riboside chloride (NR-CL) (23111-00-4)
Hawaiian Name NRC; 3-Carbamoyl-1-beta-D-ribofuranosylpyridinium chloride; Nicotinamide ribose chloride; 3-Carbamoyl-1- (β-D-ribofuranosyl) pyridinium chloride; 3-carbamoyl-1 - ((2R, 3R, 4S, 5R) -3,4-dihydroxy-5- (hydroxymethyl) tetrahydrofuran-2-yl) pyridin-1-ium chloride; Nicotinamide BD Riboside Chloride (WX900111); NR-CL;
Kāleka CAS 23111-00-4
InChIKey YABIFCKURFRPPO-IVOJBTPCSA-N
SMILE C1 = CC (= C [N +] (= C1) C2C (C (C (O2) CO) O) O) C (= O) N. [Cl-]
Ka Lā Molecular C11H15ClN2O5
Molecular Weight 290.7002
Monoisotopic Mass 290.066949 g / mole
Point Hoʻolālā N / A
kala like 'ole keʻokeʻo
Nā kikowaena temp -20 ° C Pākiho
noi i nā meaʻaiʻaiʻaiʻai, nā lāʻau lapaʻau

ʻO Nicotinamide riboside chloride

Ke ʻike nei i nā pono o ka Nicotinamide riboside (NR), he aha nā pono o Nicotinamide Riboside Chloride?

ʻO nā pōmaikaʻi o ka nikotinamide riboside chloride a me ka nikotinamide riboside he like ia no ka mea e hana ana lāua ʻelua e hoʻoulu i nā protein NAD a me sirtuin 1.

ʻO ka Metabolism olakino no ka mālama ʻana i ka momona

Ua hōʻoia nā helu o ka noiʻi i ka pono o ka nicotinamide riboside chloride i ka hōʻemi ʻana i ka kaumaha. Hiki i nā mea hoʻohana ke lilo i 10% o ko lākou kino momona me ka ʻole o ka pakani a me ka hoʻomaʻamaʻa kino.

ʻO ka lawe ʻana i ka lāʻau e kōkua i ka hoʻohaʻahaʻa ʻana i ka LDL cholesterol ʻoiai e hoʻāla ana i nā kiʻekiʻe o ka maikaʻi o ke kō. Hana ʻia kēia ke kāohi i ka hana o nā enzyme ke kuleana no ka synthesly o triglycerides. A laila, lohi ka hana ʻana o nā lipoproteins haʻahaʻa haʻahaʻa.

Hoʻopōmaikaʻi ʻo Nicotinamide riboside chloride i nā mea maʻi momona me ka maʻi kō. Hoʻonui ka mea hoʻonui i ka metabolism ma o ka hoʻomaikaʻi ʻana i ka hoʻomanawanui ʻole o ka glucose

neuroprotection

Ke hāʻule nā ​​pae NAD ma lalo o ka optimum, hiki i kāu ʻōnaehana neurological a me kou olakino noʻonoʻo ke pili. Lawe, i laʻana, nā mea maʻi me ka maʻi ʻo Alzheimer e hōʻike i ka hoʻohaʻahaʻa haʻahaʻa o NAD + a me ka hana mitochondria.

Ma waena o ka lāʻau nicotinamide riboside chloride e hoʻohana ai, ka mālama ʻana i ka neurodegeneration i ke poʻo kiʻekiʻe o ka papa inoa. Hana ka lāʻau i ke kūpikipiki intracerebral, hahau ʻana ischemic, hoʻohaunaele neurological, a me ka make neuronal.

Pākuʻi anti-kūnewa

ʻO kekahi o nā kī nui ʻo Nicotinamide riboside chloride e hoʻohana nei me ka hoʻolaha ʻana ola ʻelemakule Ke alakaʻi nei ka hui i ka hoʻonui ʻana o ka hana NAD, kahi mea nui i ka paʻalima. ʻO kahi laʻana, hoʻāla ia i nā pae ikehu pūnaewele i loko o nā mākala, ka ake, a me nā puʻupaʻa. Ma waho aʻe, pale aku ʻo Nicotinamide riboside chloride i ka senescence e ka hoʻonui ʻana i ke kahe o ke koko i loko o kēia mau mea ola.

Hoʻoponopono DNA

Hoʻopōmaikaʻi ʻo Nicotinamide riboside chloride i nā mea hoʻāo kino ma o ka hoʻoponopono ʻana i ka DNA kahiko a ʻino hoʻi. Inā hāʻule ka paʻa o NAD, hiki i ka deoxyribonucleic acid ʻeha ke hoʻoulu i nā ʻano oxygen reactive, e alakaʻi ana i ke koʻikoʻi oxidative, a me ka maʻalahi i ka maʻi ʻaʻai.

ʻO Nicotinamide riboside chloride

Pehea e hiki ai iā Nicotinamide Riboside Chloride Reverse Aging?

I ka wā ʻelemakule, ʻike ke kino i kekahi mau loli physiological ke hoʻi i hope nā hana pūnaewele. ʻO kahi laʻana, hoʻopau ke kino i nā protein NAD + a me SIRT1 ma mua o ka synthesize. ʻO nā pae haʻahaʻa o kēia mau coenzymes e hōʻeleu i ka senescence ʻoiai ke kīkē nei i nā comorbidities e pili ana i ka makahiki e like me ka maʻi diabetes, nā maʻi maʻi maʻi, a me ka momona.

Ke lawelawe nei i ka nikotinamide riboside chloride pōmaikaʻi i ka ʻōnaehana pale maʻi e ka hoʻoikaika ʻana i nā kīʻaha koko, e like me nā lymphocytes a me nā leucosit. Hoʻonui ka hui i ka synthesity o NAD +, no laila, e piʻi i luna nā pae o nā protein SIRT1. No laila, hoʻolohi ʻo SIRT1 i ka ʻelemakule vascular e ka hoʻonui ʻana i ke kahe o ke koko i nā mākala iwi, ʻōnaehana cardiovascular, a me nā aʻa neurological.

Ma waho aʻe, ʻo ka nikotinamide riboside chloride kumukanawai hoʻohuli i ka ʻelemakule e ka hana ʻana i ka NAD + hou aʻe e kōkua i ka hoʻoponopono ʻana o DNA ma loko o ka hanana pūnaewele. Pale kēia hopena i ke koʻikoʻi oxidative

Ke hōʻoia nei ka noiʻi i loaʻa i ka helu ʻana o ka nicotinamide riboside chloride countersion iwi i ka pau ʻana o ka iwi, ka hoʻemi ʻana o ka hana waimaka, a me ka hypopigmentation fundus. Hoʻonui kēia mau ʻano āpau i waena o ka poʻe ʻelemākule.

NADurs Precursors: ʻO Nicotinamide Riboside Chloride a me Nicotinamide Mononucleotide

Aia ma mua o ʻelima mau mea mua o NAD + akā no kēia manawa, hiki iā mākou ke hoʻololi i kā mākou nānā i ka nikotinamide riboside chloride vs. nicotinamide mononucleotide (NMN).

Hoʻonui kēia mau mea hoʻohui ʻelua i nā pae NAD + i ke kino e hoʻomaikaʻi ai i nā hana pūnaewele a hoʻolōʻihi i ka senescence.

ʻO ka mea e haʻi aku ai i kēia mau mea ʻelua ʻaʻole ka NMN kahi ʻano wikamina B3. ʻAʻole komo ka kemika i loko o ke kolamu a hiki i ka hoʻololi ʻana i ka ribotide nikotinamide. ʻO ke kumu o ka nui o ka nui o ka mole molaki i ʻoi aku ka nui ma mua o ka nicotinamide riboside chloride pauka. Ma muli o kēia waiwai, ka bioavailability o NMN a me kāna mau manaʻolana o ka hoʻoulu ʻana i nā pae NAD + i iwi o ka paio ma ka papa noiʻi.

Wahi a Dr. Sinclair, he genistist ma ke Kulanui ʻo Harvard, kūlike ʻole ka hoʻokō ʻana o ka NMN. Hōʻoiaʻiʻo ʻo ia i ka hoʻohana ʻana i kēia hoʻoponopono hou, ka mea e manaʻo ai iā ia he ʻōpio a hoʻoulu hou ʻia. Kūlike ʻo Sinclair i ka pono o NMN i ka holo ʻana i kahi papa hana. Ua ʻōlelo ka ʻepekema ua hoʻomaikaʻi ia i ke kahe o ke koko, paipai i ka hoʻomanawanui ʻana i nā mākala, a me ka metabolism pono.

ʻO ka mea ʻē aʻe, lawe pololei ʻia ʻo Nicotinamide riboside chloride e ka huna. ʻO ka molehe he huaʻa B3 ʻokoʻa. E hoʻonui ia i nā pae NAD + ma kahi o 60% i ke kino o ke kanaka. ʻAʻole like me ka hapa nui ʻO NAD nā mea mua, aia ma ka papa inoa kiaʻi o ka FDA, aia ka nicotinamide riboside (NR) chloride i loko o ka keʻokeʻo keʻokeʻo o GRAS (Generally Recognised as Safe) nā huahana meaʻai.

No ke aha e lawe pololei ʻole ai i ka pauma NAD? ʻO Nicotinamide Riboside Chloride vs. Nicotinamide Adenine Dinucleotide (NAD)

ʻOiai ke nānā nei mākou e pili ana i ka hoʻokiʻekiʻe ʻana i ka NAD i loko o ke kino, ke nīnau nei paha ʻoe no ke aha ke kumu o ka nicotinamide riboside chloride. ʻAʻole pono ʻoe e hoʻokele NAD pololei i kāu ʻōnaehana ma mua o ka hele ʻana i loko o ka hassle o ka hoʻohana ʻana i nā waena e like me NIAGEN, NR, a me NMN paha? ʻĀ, e ʻae ʻoe iaʻu e hoʻopōkole iā ʻoe e pili ana i ka ribotide nikotinamide klide vs nikotinamide adenine dinucleotide.

ʻO ke kumu nui āu e lawe ʻole ai iā NAD pololei ʻo ia ka meaola ʻole o ka biomarker i ka pūnaewele.

ʻO ka hoʻohui o ka hoʻohana ʻana i ka ribotide floride nikotinamide a me ka nikotinamide adenine dinucleotide ʻo ia ka permeable o ka mea mua i ka membrane plasmic. ʻOi aku ka kiʻekiʻe o ka helu o ka absorption ma o ka ʻōnaehana digestive, i loko o ke kahe o ke koko, a ʻo ka hope i ka lolo.

ʻO Nicotinamide riboside chloride

ʻO Nicotinamide riboside (NR) Chloride Dosage: Pehea e hoʻohana ai?

I ka 2016, ua lanakila ke koloka ribotide nikotinamide koloride i ke kūlana GRAS. I hoʻokahi makahiki ma mua, ua ʻae ʻo FDA iā ia ma ke ʻano he kumu o ka niacin a me kahi mea hoʻopili i nā meaʻai i kēlā me kēia lā o 180mg.

I kēia manawa, ke kiʻekiʻe o ka laikini nikotinamide riboside chloride i nā pae ma 300mg i kēlā me kēia lā. Eia nō naʻe, i loko o kekahi mau hoʻāʻo ʻana o ke kanaka, e ʻaʻai ana nā kumuhana i ka 2000mg o ka lāʻau. Pono ʻoe e hoʻomaopopo i ka ʻoi loa ʻana i ka hopena o 500mg e alakaʻi i nā hopena ʻaoʻao nicotinamide riboside insufferable

Pili wale ka lāʻau niacin ola makua, komo pū me nā wahine e kali ana a me nā makuahine lactating.

Nā hopena ʻaoʻao ʻaoʻao ʻo Nicotinamide Riboside Chloride: Palekana ia e hoʻohana i ka Nicotinamide Riboside Chloride supplement?

Palekana ʻo Nicotinamide riboside chloride pauka a palekana ia i ke kūlana i makemake nui ʻia o nā mea GRAS. ʻAʻole kēia manaʻo he kumu ʻole ko ka hui. Ma hope o nā mea āpau, he wai ke ola akā huki pū kekahi i nā upshots maikaʻi ʻole ke hōʻino ʻoe iā ia. I mea e pale ai i nā hopena ʻaoʻao, e hōʻoia i ka haʻahaʻa o kāu mea Nicotinamide riboside chloride.

ʻO kekahi o nā hopena maikaʻi ʻole e komo pū me;

  • Hoʻonāukiuki
  • 'O Nausea
  • ʻO ka wai
  • Kōkua
  • ʻO nā hopena o ka ʻili e like me ka hū a me ka hoʻonui ʻana i ka palapū

Ma waho aʻe o nā hopena ʻaoʻao nicotinamide riboside chloride, e ʻike paha ʻoe kaumaha lilo. Eia nō naʻe, he hoʻomaikaʻi kēia hopena ma ke ʻano huna inā ʻoi nui kou momona, momona, a ke hoʻāʻo nei ʻoe e mālama i kāu kaupaona.

Ma hea e kūʻai ai (NR) Nicotinamide Riboside Chloride ma Bulk?

Hiki iā ʻoe ke kūʻai i ka ribotide nikotinamide klorida e kūʻai ai ma kahi hale kūʻai pūnaewele. Inā makemake ʻoe i ka paukū papa lāʻau lapaʻau i ka nui a i ʻole i kahi papa ʻaina meaʻai, e hōʻoia e nānā i waho no kahi mea hoʻolako maoli. ʻO ka pākuʻi o ke kūʻai uila ʻana hiki iā ʻoe ke hoʻohālikelike i ke kumu kūʻai a nānā i nā manaʻo o ka mea kūʻai manawa maoli. Eia nō naʻe, e hāʻule paha ʻoe i nā mea hoʻopunipuni.

He inoa hilinaʻi mākou a pili pono kā mākou huahana i nā ana kaohi e like me ka maikaʻi. Hana mākou me nā kemika ʻokoʻa a dietary kumukanawai a. Kāhea iā mā ou no kāu kauoha a me kahi ʻōlelo aloha.

E hoʻomaopopo '
    1. Conze, D., Brenner, C., & Kruger, CL (2019). Ka palekana a me ka metabolism o ka hoʻokele wā lōʻihi o NIAGEN (Nicotinamide Riboside Chloride) i kahi hoʻokolohua kaulike kaulike, pālua makapō, Placebo-Controlled Clinical Trial of Healthy Overweight Ad pakeke. Hōʻike Pūnaewele.
    2. ʻO Bogan, KL & Brenner, C. (2008). ʻO Nicotinic Acid, Nicotinamide, a me Nicotinamide Riboside: ʻO kahi loiloi Molecular o NAD + precursor Vitamins i Human Nutr. ʻO ka loiloi makahiki o ka meaʻai.
    3. Mehmel, M., Jovanovic, N., & Spitz, U. (2020). ʻO Nicotinamide Riboside - Ke kūlana o ka noiʻi a me nā hoʻohana therapeutic.
    4. Turck, D., Castenimiller, J., et al. (2019). Ka palekana o Nicotinamide Riboside Chloride ma ke ʻano he meaʻai novel e like me ke kānāwai (EU) 2015/2283 a me ka Bioavailability o Nicotinamide mai kēia Puna, ma ka Context of Directive 2002/46 / EC. Pepa Pai ʻo EFSA.
    5. Elhassan, YS et al. (2019). Hoʻohui ʻo Nicotinamide Riboside i ka mākala kanaka ʻelemakule NAD + Metabolome a me nā Induces Transcriptomic a me nā Anti-Inflammatory Signature. Nā Pūnaewele Pūnaewele.
    6. Aman, Y., Qiu, Y., Tao, J., & Fang, EF (2018). Ka Manaʻo Therapeutic o ka Boosting NAD + i nā maʻi kūpuna a me nā makahiki. Lapaʻau unuhi o ka ʻelemakule.
    7. RAW NICOTINAMIDE MONONUCLEOTIDE (NMN) POWDER (1094-61-7)
    8. RAW LORCASERIN HCL POWDER (846589-98-8)

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