1. He aha ka Linaclotide (Linzess)?
2. He aha ka mea i hoʻohana ʻia ai ʻo Linaclotide?
3. He aha ka hana o ka hana a Linaclotide?
4. Pehea e hoʻohana ai ʻo Linaclotide?
5. He aha ka hopena no ka Linaclotide (Linzess)?
6. He aha nā hopena kūpono hiki i Linaclotide ke kumu?
7. ʻO nā lāʻau a me nā mea hoʻohui aʻe e hoʻopili ʻia me Linaclotide?
8. He aha ka ʻokoʻa ma waena o Linaclotide a me ka lubiprostone?
9. He aha nā manaʻo e pili ana iā Linaclotide e ʻike wau?


1. He aha ka Linaclotide (Linzess)?ʻO Phcoker

Linaclotide (Linzess) he lāʻau lapaʻau paʻa FDA-ʻāpono i hana pinepine ʻia e nā poʻe maʻi e loaʻa ana i ka maʻi constipation a constipation ma muli o ka huhū o ka bowel syndrome. Linaclotide 851199-59-2 hele mai ma luna pono o ka papa inoa o kahi papa lāʻau hou hou i kapa ʻia ka guanylate cyclase-C agonists.

ʻO Linaclotide ka inoa inoa inoa ʻo Linzess a he mea nui ia e hoʻomanaʻo i kēlā manawa i kēia manawa, ʻaʻohe ʻōnaehana Linaclotide. No laila, inā ke ʻimi nei ʻoe iā Linaclotide no ke kūʻai aku a hoʻohana ʻole ʻia, e kiaʻi ma luna o nā mea kūʻai kūʻē i ka lāʻau lapaʻau ʻokoʻa kūleʻa i kūʻai kūleʻa ʻole ʻole ʻia ʻO Linaclotide generic ka lāʻau lapaʻau.

ʻO Linzess kahi guanilate cyclase-C agonist a me kahi peptide 14-amino acid. ʻo ia ka inoa kimia ka L-cysteinyl-L-cysteinyl-L-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonyl-glycyl- L-cysteinyl-L-tyrosine, cyclic (1-6), (2-10), (5-13) -tris (disulfide).

ʻO kāna hana molekole ʻo C59H79N15O21S6 aʻo ke kaupaona molekala ʻo 1526.

Lokeclotide pauka ka keʻokeʻo ma keʻokeʻo a keʻokeʻo iki i ka wai. Hiki iā ia ke lemu iki i loko o ka wai sodium chloride (0.9%).

ʻO ka hope Linzess aia ma ke ʻano o nā kapula gelatin paʻakikī e loaʻa ana i nā manikele i hoʻolele ʻia ʻo Linaclotide. ʻO ka calcium calcium chloride dihydrate, L-leucine, titanium dioxide, microcrystalline cellulose, gelatin, me ka hypromellose aia kekahi o nā mea hana a Linzess

2. He aha ka mea i hoʻohana ʻia ai ʻo Linaclotide?ʻO Phcoker

A hiki aku ʻo Linaclotide e hoʻohana, hoʻohana nā kānaka iā ia ma ka mālama ʻana i nā pilikia bowel kūikawā e like me ka irritable bowel syndrome i hōʻailona ʻia e nā constipation a me kahi maʻi idiopathic constipation.

He aha kāu e ʻike pono ai e pili ana i ka constipation Linaclotide

Linaclotide no nanaina aku na naau oʻu syndrome nā hōʻailona

Nā maʻiʻeha o ke kīhaʻeʻole (IBS) he manawa lōʻihi ka mea e pale aku ai i nā ʻōpū i hana maʻamau. ʻO kēia hōʻailona Linaclotide ka mea i kapa ʻia ʻo ia ka lāʻau spastic a i kekahi manawa nā maʻi bela i hana ʻia. ʻO nā hōʻailona nui o ka maʻi ka constipation, ke nānā ʻana a me ka ʻeha o ka ʻōpū me ka constipation a i ʻole ke hoʻololi ʻana me ka maʻi ʻaʻai.

I loko o kahi noiʻi haukapila e hoʻokumu ai i ka hopena o Linaclotide no ka hōʻoluʻolu o ka maʻi ʻoluʻolu bowel syndrome hōʻailona, ​​ua hoʻohana ʻia nā mea maʻi ma nā hanana ʻelua, hoʻokolokolo multicenter. ʻO ka hoʻokolokolo mua e pili ana i nā maʻi 800 i kau ʻia ma 290 mcg papa lāʻau maʻamau linzess i kēlā me kēia 804 i hāʻawi ʻia i ka lua o ka mea ma ka placebo.

Ua loaʻa nā maʻi āpau i hoʻohana ʻia i nā ʻāpana ʻelua i nā kūloko a IBS Roma II a manaʻo ʻia e hoʻokō ʻia nā loaʻa ʻana o ka ʻeha o ka ʻōpū o 3 ma ka liʻiliʻi ma ke kiko o ka ʻumi a ʻumi a he ʻekolu mau kiki o ka hanana kiki kūpono i kēlā me kēia pule i kēlā me kēia pule o ka mālama ʻana. wā hana.

Ma ka hopena o ke kaʻina hana, ʻoi aku ka nui o nā mea maʻi ma ka papa linzess e hoʻomaikaʻi ʻia e hoʻomaikaʻi hou aku i nā hōʻailona BIS e like me ko lākou kikoʻī placebo i nā ʻōlelo o ka

  • Kūleʻa hāmeʻa i ka piʻokeʻo
  • Ka lahui ʻo Stool
  • Ka nui o ka manawa a me ke ʻano ikaika e hoʻohana ai kekahi i nā kaʻa.
  • ʻAlaʻeha hōʻeha ʻeha

Ua hōʻoiaʻiʻo ʻo ia i ka hōʻike Linaclotide ma ke ʻano he lawelawe kūpono no ka BIS.

Linaclotide no Nā hōʻailona maʻi Idiopathic Constipation (CIC)

I ke aʻo ʻana e nānā ai i ka pono o Linzess no CIC nā hoʻokolohua hōʻailona, ​​nā poʻe maʻi me nā maʻi idiopathic constitation i kau ʻia ma nā hanana randomized, multicenter hoʻokolohua hoʻokolohua, like like me ka BIS i hōʻike ʻia ma luna nei.

Ua loaʻa i kēlā me kēia o nā mea maʻi ke hoʻololi ʻia ʻana o nā mana kō constipation o Roma II a loaʻa 72mg, 145 mcg Linzess, 290 mcg Linzess a i ʻole ka hana placebo i kēlā me kēia lā a puni ka hana mālama 12-pule.

I ka pau ʻana o ka manawa lapaʻau, ʻike ka poʻe noiʻi hou i ka holomua ʻana o ka maʻi CIC i waena o nā poʻe maʻi e pili ana i ka hoʻomaʻamaʻa ʻana o Linzess e like me ka poʻe ma ka placebo. ʻO ka maʻamau, ua ʻike lākou i ka holomua o ka pae kiʻekiʻe e pili ana i ka nui o ka stool frequency, ka hana a ka stool a me ka nui o ke neʻe ʻana i ka nui o ka bowel.

ʻO nā helu āpau a ʻekolu mau Linzess, loaʻa nā hopena ʻokoʻa ma kahi o ka hāʻawi ʻana i nā hōʻailona koʻikoʻi CIC. Hōʻike kēia i ka hōʻike Linaclotide o kona hiki ke mālama i ka CIC.

He aha kāu e ʻike pono ai e pili ana i ka constipation Linaclotide

3. He aha ka hana o ka hana a Linaclotide?ʻO Phcoker

ʻAʻole i like me kekahi mau lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i nā pilikia olakino i ʻōlelo ʻia, heʻokoʻa ka ʻano o Linaclotide-ʻaʻole ia i komo i loko o kou kino. ʻŌnaehana Linaclotide e hana pono i loko o kou mau ʻōpū ma o ka hoʻonui ʻana i ka wai, a no laila e hoʻomaikaʻi ai i ke neʻe ʻana a me ka hōʻoluʻolu ʻana i ke ʻeha ma muli o kahi pilikia ʻāpana.

ʻO Linaclotide (Linzess) e hana i nā ʻōpū i mea e hoʻoulu hou ai i ka wai ma o ka hoʻonui ʻana i ka hana o nā monophosphate cyclic.

Ke hoʻohana nei ʻo Linaclotide i kona mana e hoʻonui i ka wai i loko o kou mau ʻōpū, holo ka ʻai ma o ka palahalaka ʻoi aku ka maikaʻi o ka hana stool. Hoʻomaikaʻi kēia i nā hōʻailona o ka hōʻailona e pili ana i ka iwi bowel like me ka lula, ka ʻōpū a me nā ʻōpū o ka ʻōpū a me ke ʻano piha ʻana i ka naʻau.

4. Pehea e hoʻohana ai ʻo Linaclotide?ʻO Phcoker

I ka wā e hana ai a Kūʻai aku ʻo Linaclotide, ʻoiaʻiʻo me kahi kauka a nā kauka, pono ia e hōʻoia i ka heluhelu ʻana i ka alakaʻi lapaʻau e hāʻawi ʻia e kāu lāʻau lapaʻau ma mua o ka lawe ʻana i ka lāʻau. E haʻi ka alakaʻi iā ʻoe i ka dosis Linaclotide kūpono loa iā ʻoe, nā kikowaena dosage kūpono a me ka manawa papa aʻoaʻo i ʻōlelo ʻia ʻia.

I ka hihia āu e pono ai i kekahi wehewehe Paʻi Linaclotide, mai kānalua e hoʻopili i kāu kauka a i ʻole kauka lāʻau e pale aku ai i ka hopena o Linaclotide a i ʻole ka hopena o Linaclotide.

ʻO ka lilo ʻana o ka lāʻau lapaʻau waha, pono ʻia e Linaclotide e ka waha. Pono ʻoe e lawe a nānā ʻole ka ʻōpū, ʻoi aku ka maikaʻi o nā minuke 30 ma mua o ka lawe ʻana i kāu papaʻaina mua i kahi lā. ʻO ka lāʻau Linaclotide hope loa i loko o kahi capsule a pono e ʻoki loa. ʻAʻole ʻoe e wāʻoki a i ʻole nā ​​pipi Linaclotide capsules.

Eia nō naʻe, inā ua hoʻāʻo ʻoe e ale i nā kapia akā he lapuwale, hiki iā ʻoe ke wehe iā lākou a kāwili i nā ʻikepili i loko o kahi pihi appleauce. A laila hoʻokaʻawale koke i ke kāwili a me ke ʻano ʻole. Kāwili wale i ka nui o kāu e lawe ai i kēlā manawa no ka mea ʻo ka mālama ʻana i ka palu e hoʻoneʻe ai ka lāʻau lapaʻau i kona pono.

I ka hihia ʻaʻole āu apelauce, hiki iā ʻoe ke hoʻohana i ka wai ma kahi ʻano. E ana i hoʻokahi ounce a i ʻole 30mm o ka wai, e wehe i nā kapia wai Linaclotide i ʻōlelo ʻia a pani ʻole i nā mea i loko o ka wai. E piu i ka wai-Linaclotide kiʻi no kahi sekona 20 a laila inu koke koke. E like me kāwili apelau, mai ʻānai aku i ka ʻōlelo.

I ka hihia ke kumu o ka lāʻau lapaʻau e mālama ʻia ma o ka uka nasogastric a i ʻole gastric, e ʻimi i ke alakaʻi i ka hoʻokele mai kāu lāʻau lapaʻau a kauka paha. Eia naʻe, eia ka hana maʻamau no ka hoʻokele tube.

  • Pahu i ka 30 ml wai o ka wai maʻemaʻe a me nā keʻokeʻo a i loko o ka wai a waiho i loko o kahi wai maʻemaʻe.
  • E wehe i ka linaclotide capsule a wehe i kāna ʻikepili piha (beads) i ka wai
  • I waena o ka wai a me nā manikā Linaclotide e ka hoʻomāwili ʻana i ka palu ʻana no ka liʻiliʻi ma mua o 20 kekona.
  • E kahakaha i ka wai hoʻoneʻe Linaclotide i loko o kahi syringe kūpono me kahi hāhi e like me ka pahu o ka catheter a me ka nui. A laila e hoʻolilo i ka hoʻohuihui i loko o ka uka nasogastric a gastric paha i hoʻohana ʻia e ka mea maʻi e ka hoʻomau ʻana akā wikiwiki ka wikiwiki o 10 mL / 10 mau kekona ma ka ʻāʻī.
  • I nā hihia ma laila kekahi mau manu Linaclotide i waiho ʻia i loko o ka ipu, hoʻohui i 30ml o ka wai maʻemaʻe i loko o ia mea, hoʻoulu i ke kāwili, a lawelawe hoʻi e like me ka mea i hōʻike mua ʻia ma mua.
  • I ka manawa e pau ai me ka hoʻokele ʻana i ka hui ʻana o ka ʻinā Linaclotide a me ka wai, e hoʻohana i ka liʻiliʻi 10 ml wai e hoʻoheheʻe i ka wai hoʻokele.

5. He aha ka hopena no ka Linaclotide (Linzess)?ʻO Phcoker

Ka ʻokoʻa Linaclotide ka hopena i kēlā me kēia kanaka i kekahi, e pili ana i ke kūlana i manaʻo ʻia e mālama pū kekahi e like me ke pane ʻana o kekahi i ka lāʻau lapaʻau. Eia hou, he mea nui e hoʻomaopopo ka pono o ka lāʻau e hoʻohana pono ʻia e nā poʻe ʻaʻole i hiki i ka makahiki o 18 mau makahiki.

Loaʻa i nā keiki liʻiliʻi ʻōpiopio ke ʻike i ka pilikia loa ʻO nā hopena pili o Linaclotide pono lākou e hoʻohana i ka lāʻau.

(1) Dosis makua makua makua no ka huhū ʻ Bowlelo Syilika

No kahi pākeke e hōʻeha nei i ka Irritable Bowel Syndrome me ka constipation, pono ia e lawe i kahi Linaclotide dosis o 290 mcg i kēlā me kēia lā. E like me ka mea i ʻōlelo ʻia ma mua, pono e lawe ʻia ka lāʻau ma luna o ka ʻōpū ʻole. E hōʻoia i kēlā, e lawe ma mua o ka ʻaina mua o ka lā.

(2) Wehewehe makua makua makua no ka constipation

Wahi a ka US Food and Drug Administration, ʻo ka Linaclotide ka ʻōlelo i hōʻike ʻia no ka pākeke me ka maʻi indiopathic constipation (CIC) ʻo 72 mcg.

Eia nō naʻe, hiki ke ʻōlelo ʻia i kahi hāmeʻa 145 mcg no kahi mea maʻi pākē me CIC, ma muli o kona hōʻike a me ka ʻoluʻolu. Hiki iā ʻoe ke hōʻoia Nā kūkākūkā linzess 72 mcg e kiʻi i ka pehea e hana ai ka pākē a me nā mea hoʻohana i hoʻomaikaʻi ʻia mai ia.

Wahi a nā loiloi linzess 72 mcg, ma waena o nā ʻōlelo whakahoki e pili ana i ka lāʻau lapaʻau, kahi mea maʻi me nā pilikia olakino i haʻi ʻia a nānā i ka pōmaikaʻi ʻana i kona hiki ke hoʻohana mau iā ia no ka hoʻokō ʻana i nā hopena makemake. Ma waho aʻe, pono e lawe i ka manawa like i kēlā me kēia lā i loko o ka manawa papa hana hoʻonaʻauao ʻia.

He mea nui ia e hoʻomaopopo he līlī paha ʻo Linzess i ka hoʻopili ʻana o Linaclotide me nā lāʻau like ʻole. I kahi mea, pono ʻoe e hōʻike i kāu kauka e pili ana i ka lāʻau lapaʻau āu e kau nei ma mua o ka hoʻomaka ʻana e hoʻohana i ia (Linaclotide).

Eia kekahi, pono e mālama nā wahine hāpai i ka mālama ʻana iā Linaclotide no ka mea hiki i ka lāʻau lapaʻau ke mālama koʻikoʻi i ka pēpē. E ʻimi lākou i ka nānā ʻana o ke kauka e hōʻoia i ko lākou palekana a i kā lākou mau keiki ʻaʻole pono e lawe i ka lāʻau. Hoʻopau ka hihia like ʻole i nā makuahine hānai a me nā mea āu e makemake ai e hoʻoulu i ka wā e hoʻohana ana i ka lāʻau.

Eia nō naʻe, inā he CIC a i ʻole Irritable Bowel Syndrome, ʻo nā mea maʻi ma lalo o ka makahiki o 6 mau makahiki ʻaʻole e lawe. ʻO ka paukū Linzess (851199-59-2). Ua nānā ʻia nā hoʻokolohua hoʻokolohua he hopena ka mea i make i nā make i nā kiʻiki wai me nā makahiki i kēlā me kēia ma lalo o nā makahiki 6 i loko o nā kānaka.

Me ka mea, ua hoʻonā ʻia ka lāʻau lapaʻau no nā poʻe maʻi ʻaʻole i hiki i ka makahiki e like me ke kau ʻana iā lākou i kahi koʻikoʻi nui loa o ka hoʻomohala ʻana i ka maʻi maʻamau a me nā hopena pōʻino koʻikoʻi.

Ma waho aʻe o kēia, aia nā hōʻike klinika e hōʻike ana i ka palekana a me ka maikaʻi o ka linzess ma waena o nā mea maʻi i hala ka makahiki 6 a hiki i 17 mau makahiki. E like me, i ka wā o kahi keiki a i ʻole ke ʻōpio ma lalo o 18 mau makahiki e pono ai ka hoʻomaha ʻana o ka ICI a i ʻole BIS, pono e ʻimi ʻia nā ʻōlelo aʻo a ke kauka.

Hiki iā ʻoe ke lawe i ʻelua pule ma mua o kou ʻike ʻana i ka hōʻeha ma muli o ka lāʻau. No laila, e ahonui nui me ia. E hoʻomau e hoʻohana e like me ke kuhikuhi.

Eia nō naʻe, inā ʻaʻole e hoʻomaʻamaʻa a hoʻomaikaʻi paha kou ʻōuli a ma hope o ka hoʻohana ʻana i ka linzess, mai lawe i kahi laʻana ma mua o ka nui i kuhikuhi ʻia. ʻAʻole pono ʻoe e hana i kēlā me kēia hihia. Ka mea, e hoʻomaopopo i kāu kauka e hoʻokumu i ka mea ma hope o ka maikaʻi ʻole o ka lāʻau lapaʻau a me ke ʻōlelo aʻoaʻo i ka ʻaoʻao e hiki ai.

He mea pono e pale i ka hoʻohana ʻana iā Linaclotide inā ua kūleʻa ʻoe iā ʻoe a i ʻole kou ʻili o ka pale.

Inā hele ʻole ʻoe i kahi laʻai Linaclotide, mai hoʻāʻo e hana i ka lāʻau i hala. E poina e pili ana iā ia a hoʻomau i ka lawe hou ʻana i nā inea hope loa i ka manawa i hoʻonohonoho ʻia.

I ka hihia a i ʻole kāu mea aloha e lawe i kahi nui o Linaclotide (overdose), pono e lawe koke ʻia ka mea maʻi i ka manaʻo o ke kauka. ʻO kahi koho, hiki iā ʻoe ke kelepona i nā lawelawe kōkua Poison ma ke kāhea ʻana iā 1-800-222-1222.

He aha kāu e ʻike pono ai e pili ana i ka constipation Linaclotide

6. He aha nā hopena kūpono hiki i Linaclotide ke kumu?ʻO Phcoker

Wahi a kēlā me kēia ʻano Hōʻike Linaclotide a me nā ʻepekema ʻepekema, eia nā hopena maʻamau Linaclotide:

  • ʻOhiʻeha ʻohi
  • ʻO ka ʻeha ʻeha a paʻakikī paha
  • bloating
  • kapunika
  • luaʻi,
  • Heʻeha
  • ʻO nā hōʻailona ʻeha e like me ka ihu a holo / manamana, ʻeha ʻeha a ʻeha paha a ʻā paha paha
  • nā'ōpū
  • pepeiao pepeiao
  • wela
  • leo pio
  • ka hale hoʻolima
  • ʻo ka mea ʻā a i ʻole paha ka ihu
  • kūlohelohe
  • convulsions
  • maka maka
  • ʻāʻī paʻa

ʻOiai ʻaʻole pilikia, hiki iā ʻoe ke loaʻa kekahi o kēia mau hopena ma ka hope Linaclotide:

  • ʻO ka hōʻeha a hoʻomau paha paha
  • ʻO ka maʻi i hele pū ʻia e ka dizziness a i ʻole kahi manaʻo e manaʻo ai e like me ʻoe e hala paha
  • Pāpū ka lima
  • Nā loli maʻamau
  • Pau ka manaʻo
  • Ka hilahila maʻamau
  • Nā wāwaeʻoluʻoluʻole
  • Ka māhuahua mau a hoʻomau ʻole ʻia
  • Puʻu polipi
  • ʻAne aloha
  • Ka nāwaliwali o ka puʻupuʻu
  • ʻO ka ʻeha ʻeha
  • ʻeleʻele, he ʻai, a i ʻole ka līe launa ʻole
  • hives
  • paʻakikī ka hanu
  • helehelena, lehelehe, lehelehe, a me ke kākā

Pono ʻoe e ʻimi i ka kōkua kōkua inā loaʻa iā ʻoe kahi pōkole ma nā ʻaoʻao i ʻōlelo ʻia, nā pilikia ʻōpū a me nā hives.

I ka hopena o nā hopena ʻokoʻa Linaclotide e pau, pono e oki i ka hoʻohana ʻana i ka lāʻau lapaʻau a hui koke i kāu kauka no ka alakaʻi hou aku.

7. ʻO nā lāʻau a me nā mea hoʻohui aʻe e hoʻopili ʻia me Linaclotide?ʻO Phcoker

ʻO nā lauʻoihana Linaclotide Hiki paha i ka hihia ʻo Linaclotide e hui pū me nā lāʻau ʻē aʻe e pili ana i ka poʻe over-the-counters, nā huaora, nā lāʻau lapaʻau a me nā lāʻau lapaʻau i kauoha ʻia. ʻO kekahi o nā lāʻau lapaʻau i hōʻike ʻia e hoʻolilo ʻia i nā hoʻopili Linaclotide e komo:

  • Hoʻopili
  • Amitiza
  • Aspir 81
  • Kahi ikaika Aspirin
  • 'Ohau
  • Kākau
  • Dulcolax (hui liʻiliʻi)
  • Hui
  • Cymbalta
  • Dexilant
  • ʻIliʻili
  • Metamucil (hui liʻiliʻi)
  • ʻO ka Levothyroxine (i ka hoʻololi ʻana o ka hoʻokolohua)
  • hoʻoiho
  • Metoprolol Succinate ER
  • Norco
  • ʻO Paracetamol
  • Hoʻomaopopo
  • Laulā
  • Vitamin B12
  • Vitamin C
  • Vitamin D3
  • Xanax
  • Zyrtec

8. ʻOkoʻa ka ʻokoʻas waena o ʻO Linaclotide a me ka lubiprostone?ʻO Phcoker

elua ʻO Linaclotide a me ka lubiprostone ʻo ia nā lāʻau DFA-ʻae ʻia no ka constipation idiopathic maʻi a me ka huhū ʻehaʻeha i ka maʻi makua. Inā makemake ʻoe i ka hana o ka pēpē i hoʻonui ʻia, hiki iā ʻoe ke koho i kekahi o nā ʻelua.

Eia nō naʻe, he nui ko lākou ʻokoʻa i loko o nā ʻōlelo o:

(1)ʻO kā lākou papa helu

No ka Lubiprostone kekahi papa lāʻau lapaʻau i kapa ʻia ʻo nā mea hoʻoikaika o ka miki wai. Ma kekahiʻaoʻao, Linaclotide (Linzess) he lālā papa o ka lāʻau lapaʻau i kapa ʻia ka guanylate cyclase-C agonists.

(2)ʻO ka helu kala i kēlā me kēia lā

ʻOiai ke kuhi ʻia ʻo Linaclotide e ʻōlelo ʻia i hoʻokahi manawa i ka lā, ʻoiai ma mua o ka ʻaina kakahiaka, ʻokoʻa ʻo Lubiprostone e lawe ʻelua i ka lā. No laila, inā pilikia ʻoe i ka hoʻomanaʻo ʻana e lawe i kāu mau lāʻau lapaʻau i kēlā me kēia lā, Linaclotide e koho pono iā ʻoe.

ʻO kekahi mea e ʻokoʻa ai ka ʻelua i ka ʻōlelo o ke anawaʻa ka nui o kekahi e lawe i ka manawa hoʻokahi. No ka laʻana, no CIC, ua ʻōlelo ʻia ʻo Linaclotide pā hoʻokahi a me 72 mcg ka mea a Lubiprostone he 8 mcg.

(3)Hoʻohui nūhou

ʻO kekahi ʻē aʻe Linaclotide pauka (851199-59-2) a me ka lubiprostone e pili ana i ka hoʻopili ʻana i ka lāʻau. Me ka ʻike e pili ana i nā lāʻau lapaʻau 58 i ʻike e pili pū me Linaclotide, ʻoi aku ka nui o nā pilina o Linaclotide i hoʻohālikelike ʻia i ka lubiprostone e pili pū ana me ka hui pū kekahi.

(4)ʻO ka lā hōʻoia

Ua apono ʻia ʻo Linzess ma 30ʻAukake 2012 aʻo ka ʻae ʻana o ka lubiprostone i hana ma Ianuali 31, 2006

(5)Hoʻohui pili i nā meaʻai

I ka loaʻa ʻana o ka meaʻai i loko o kou ʻōpū a lawe ʻoe iā Linaclotide, ʻo kou mau maʻi gastrointestinal e like me ke kūkala, ka ʻōpū a me ka mīkini ʻana e pōʻino loa, e aloha ana iā Linaclotide-hoʻopili kai. Ma kahi e ulu ai ʻoe i nā maʻi ʻoiau koʻikoʻi, a ke lawe nei ʻoe i kekahi lāʻau lapaʻau hou, ʻo ka hoʻopili ʻana o ka hopena.

No ka hōʻemi ʻana i ka uluʻana gastrointestinal ma muli o ka hoʻopili ʻana i ka meaʻai, manaʻo ʻia ʻo Linaclotide e lawe ʻia ma kahi ʻōpū ʻole.

Ma ka ʻaoʻao ʻē aʻe, aia ka ʻepekema hōʻike hōʻoia o ka Lubiprostone-kahi o nā pili o ka meaʻai. Akā naʻe, ʻaʻole kēia e hoʻoholo i nā kamaʻilio hiki. E like me kēia, he mea nui e ʻimi i nā wehewehe maikaʻi loa i ka manawa maikaʻi e hoʻohana i ka lāʻau lapaʻau mai kāu mea mālama olakino

(6)Loaʻa ʻia kahi maʻi māmā i nā makuahine hāpai

Ma kēia manawa, hōʻike kahi ʻāpana o ka noiʻi a me nā loiloi ʻo Linaclotide e manaʻo nei he mea nui paha ka Lubiprostone e hoʻopōʻino i ka wahine wahine. Ma ka lima ʻē aʻe, ʻaʻohe hoʻokahi aʻoi e hōʻike nei e hiki iā Linzess ke hōʻeha i ka hopena o ka wahine ma ka hihia i lawe ʻia e ka wahine manaʻo.

Uaʻike ke ʻepekema ʻepekema i kēia palekana ʻike i ka liʻiliʻi o ka hoʻopili ʻana o ka lāʻau. Eia naʻe, ʻaʻole hiki ke hoʻokele ʻia ka hopena me ka noiʻi no ka ʻike hou aku nei i ka palekana a i ʻole ka weliweli o ka lāʻau i ke keiki hānau ʻole.

No laila, inā e manaʻo paha e lawe iā Lubiprostone a i Linaclotide, pono ke kūkā ʻo ka wahine hāpai i kahi kauka e pili ana i ka kūpono o ka hoʻoholo.

(7)Kahalaoa

He aha kāu e ʻike pono ai e pili ana i ka constipation Linaclotide

Ma waho aʻe o ka CIC, hiki i ka lubiprostone ke b

e hoʻohana ma ke ʻano he ʻano maʻi no Opioid-induced constipation (OIC) a me Irritable bowel syndrome me ka constipation i nā wahine ma lalo o ka 18 mau makahiki kona makahiki.

I ka hiki ʻana iā Linaclotide, ʻokoʻa ka CIC, mālama pū kekahi i ka maʻi bowel irritable e hele pū ana me ka constipation (IBS-C) i ka wahine a me ka kāne. ʻAʻole ia i hoʻohanaʻia no ka mālama ʻana i ka OIC.

(8)ʻO ka kumukūʻai Linaclotide

Ke hiki mai ʻO ka kumukūʻai Linaclotide, ʻoi aku kahi kiʻekiʻe ma mua o ka lubiprostone. I kēia manawa, ʻo Linaclotide kumukūʻai e pili ana i $ 450 no nā kapena 30 aʻo 60 mau kapena o ka lubiprostone e pili ana i $ 396. Eia nō naʻe, ʻokoʻa nā kumukūʻai mai kekahi mea kūʻai aku a i kēlā me kēia manawa.

(9)Hookah

ʻO ka mea hana na Linaclotide kahiʻoihana i kapa ʻia ʻo Allergan aʻo lubiprostone kahi huahana o ka hui ʻo Sucampo.

ʻOiai ke ʻano o nā ʻokoʻa ma luna, he mea nui e hoʻomaopopo e kūʻai ʻia ka lubiprostone a me Linaclotide i ka mea kūʻai aku i ka waha capsule waha a ʻaʻohe o lākou mau generics. Pēlā nō, pono i nā lāʻau lapaʻau ke noi aku i ke kauka no ka mea e loaʻa iā lākou mai nā mea kūʻai aku.

9. Heaha ʻike hou aʻe e pili ana i Linaclotide i maopopo iaʻu?ʻO Phcoker

E like me nā lāʻauʻokoʻa ʻē aʻe, ʻo Linaclotide pauka (851199-59-2) pono ke mālama ʻia i nā kapoti mai ka lōʻihi o ke alo o ke keiki e pale aku ia lākou mai ka hana ʻino. Eia kekahi, i ka mea he lāʻau lapaʻau ʻole, e hoʻowalewale kekahi poʻe e kaʻana i ke ʻano me ka poʻe ʻē aʻe e pale i ka pilikia ʻana o ka hele ʻana i kahi kauka no ka lāʻau lapaʻau.

Eia nō naʻe, ʻo ka wehe ʻana i ka Linaclotide me ka pilikia no ka mea, pono i ke kauka ke kau i nā mea he nui i ka noʻonoʻo ʻana ma mua o ke kuhikuhi ʻana i ka lāʻau lapaʻau a kāpae i ke ala e hiki mai ai i nā hopena pōʻino nui.

I ka hihia āu e makemake ai e kūʻai i kahi Linaclotide e kūʻai, pono ʻoe e ʻike ma ka hapa nui o nā ʻāina, ʻo ia hoʻi me ka US, pono ʻoe i ka laʻana i kauka no ka loaʻa ʻana o ka lāʻau lapaʻau. He hana ʻole kēia i ka manaʻo āu e kūʻai iā ia i ka pūnaewele a i ʻole ka luna o ka counter.

Inā loaʻa ia i ka mālamaʻana, ke kuhi ʻana i mālama ʻia no ka Linaclotide 851199-59-2 ka 25 ° C (77 ° F). Inā paha ʻoe e pili ana i ka Linaclotide powder a i ʻole ka capsules, e mālama ʻia ka lāʻau lapaʻau i kahi wahi ʻuʻuku a ʻaʻole pono e hoʻemi ʻia a hoʻihoʻi ʻole ʻia. Akā, mālama i ka lāʻau holoʻokoʻa i kāna pahu kumu.

Eia kekahi, e hoʻopaʻa paʻa i ka ipu me ka desiccant i loko e mālama i ka umauma.

A makemake paha ʻoe e kūʻai iā Linaclotide 851199-59-2 no ka hoʻohana ʻana i ka ʻoihana, ʻo Linaclotide no ke kūʻai a i ʻole nā ​​hoʻohana ʻana o Linaclotide, e hōʻoia e loaʻa iā ia mai kahi punahele a hilinaʻi. Hiki i nā loiloi Linaclotide pūnaewele ke alakaʻi iā ʻoe i kahi mea kūʻai maikaʻi.

Inā ʻaʻole, me ka hana ʻana o ka ikaika pono, ʻo kēlā mea kūʻai ma waho / e kūʻai aku i ka pūnaewele i ʻōlelo ʻia he ʻoiaʻiʻo Kūʻai ʻo Linaclotide e hoʻohuli paha i ke kūʻai ʻana aku i nā huahana a i ʻole nā ​​ʻaihue i kāu kālā paʻakikī.

E hoʻomaopopo '

  1. Andresen, V., Camilleri, M., Busciglio, IA, Grudell, A., Burton, D., McKinzie, S., ... & Currie, MG (2007). Ka hopena o nā lā 5 linaclotide ma ka transit a me ka hana bowel i nā wahine me ka constipation-predominant irritable bowel syndrome. Ke kūlanaʻike, 133(3), 761-768.
  2. Chey, WD, Lembo, AJ, Lavins, BJ, Shiff, SJ, Kurtz, CB, Currie, MG, ... & Baird, MJ (2012). Linaclotide no ka huhū bowel syndrome me ka constipation: kahi 26-hebedoma, randomized, pāpālua-makapō, hoʻāʻo ʻia e waiho ana i loko o ka placebo e loiloi ai i ka pono a me ka palekana. ʻO ka papa inoaʻAmelika o ka gastroenterology, 107(11), 1702.
  3. Cuppoletti, J., Blikslager, AT, Chakrabarti, J., Nighot, PK, & Malinowska, DH (2012). Hoʻohālikelike i ka hopena o ka linaclotide a me ka lubiprostone ma ka hoʻihoʻi ʻana o nā waiwai o ka cell barit epithelial a me ka home cellasis ma hope o ka hoʻolaha ʻana i nā mea kaumaha i loko. Kauka lāʻau BMC, 12(1), 3.
  4. Harris, A. (2013). LINACLOTIDE. Point.
  5. Johnston, JM, Kurtz, CB, Drossman, DA, Lembo, AJ, Jeglinski, BI, MacDougall, JE, ... & Currie, MG (2009). Pili ka Pilot i ka hopena o ka linaclotide i nā mea maʻi me ka constipation maʻi. ʻO ka papa inoaʻAmelika o ka gastroenterology, 104(1), 125.
  6. Lembo, AJ, Kurtz, CB, MacDougall, JE, Lavins, BJ, Currie, MG, Fitch, DA, ... & Johnston, JM (2010). Ka hopena o ka linaclotide no nā poʻe maʻi me ka constipation maʻi. Ke kūlanaʻike, 138(3), 886-895.
  7. Lembo, AJ, Schneier, HA, Shiff, SJ, Kurtz, CB, MacDougall, JE, Jia, XD,… & Jeglinski, BI (2011). ʻElua mau hanana hoʻokolohua ʻelua o ka linaclotide no ka constipation maʻi. ʻO ka nūpepaʻo New England Journal of Medicine, 365(6), 527-536.